Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nellikunja J. Prakash"'
Autor:
Prasad S. Sunkara, Nellikunja J. Prakash, Philippe Bey, Donald P. Matthews, Terry L. Bowlin, James R. McCarthy, Edwards Michael L, Esa T. Jarvi, Shujaath Mehdi
Publikováno v:
ChemInform. 22
The design and synthesis of (E)- and (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (6 and 13, respectively), a new class of mechanism-based inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, is described. A number of analogues of 6 and 13 wer
Autor:
Nellikunja J. Prakash, Terry L. Bowlin, Edwards Michael L, James R. McCarthy, Gregory F. Davis, Esa T. Jarvi
Publikováno v:
Life Sciences. 50:1425-1435
S-Adenosylhomocysteine hydrolase (AdoHcy-nase) is a key enzyme in transmethylation reactions. The objective of the present study was to examine the potential antiretroviral activities of novel mechanism-based irreversible AdoHcy-nase inhibitors. (Z)-
Autor:
Donald P. Matthews, Shujaath Mehdi, Terry L. Bowlin, Edwards Michael L, James R. McCarthy, Prasad S. Sunkara, Nellikunja J. Prakash, Esa T. Jarvi, Philippe Bey
Publikováno v:
Journal of medicinal chemistry. 34(2)
The design and synthesis of (E)- and (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (6 and 13, respectively), a new class of mechanism-based inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, is described. A number of analogues of 6 and 13 wer
Autor:
Shujaath Mehdi, Prasad S. Sunkara, Philippe Bey, Edwards Michael L, Nellikunja J. Prakash, James R. McCarthy, Terry L. Bowlin, Jarvi Esa T, Donald P. Matthews
Publikováno v:
Journal of Medicinal Chemistry. 36:518-518
Autor:
J Koch-Weser, Nellikunja J. Prakash, Albert Sjoerdsma, J. Grove, PJ Schechter, Fozard, Marie-Louise Part
Publikováno v:
Science. 208:505-508
The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and
Autor:
Jan Koch-Weser, Pierre S. Mamont, Paul J. Schechter, Albert Sjoerdsma, Nellikunja J. Prakash, Jeffrey Grove
Publikováno v:
Life Sciences. 26:181-194
α-Difluoromethylornithine (α-DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC), retarded the growth rate of EMT6, a murine mammary sarcoma, in tissue culture. When female BALB/C mice were inoculated subcutaneously w
Publikováno v:
FEBS Letters. 150:397-399
Publikováno v:
Progress in Polyamine Research ISBN: 9781468456394
The availability of α-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase (ODC) made it possible to demonstrate an essential role for polyamines in cell proliferation and differentiation.1, 2, 3 Polyamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f86e052c2a2c6179ed6298daae8678ec
https://doi.org/10.1007/978-1-4684-5637-0_62
https://doi.org/10.1007/978-1-4684-5637-0_62
Publikováno v:
Annals of the New York Academy of Sciences. 419
Publikováno v:
Mechanisms of Cancer Metastasis ISBN: 9781461296461
The naturally occurring polyamines, putrescine, spermidine, and spermine, are ubiquitous in eukaryotic organisms. The structural formulae for these physiological cations are shown in Figure 1. Although Leeuwenhoek’s discovery of spermine as precipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd8b57fdd0ca31036e5ee4e919aac76e
https://doi.org/10.1007/978-1-4613-2635-9_7
https://doi.org/10.1007/978-1-4613-2635-9_7