Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nellie Y. Loh"'
Autor:
Feng-Chih Kuo, Matt J. Neville, Rugivan Sabaratnam, Agata Wesolowska-Andersen, Daniel Phillips, Laura B.L. Wittemans, Andrea D. van Dam, Nellie Y. Loh, Marijana Todorčević, Nathan Denton, Katherine A. Kentistou, Peter K. Joshi, Constantinos Christodoulides, Claudia Langenberg, Philippe Collas, Fredrik Karpe, Katherine E. Pinnick
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111136- (2022)
Summary: Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for ad
Externí odkaz:
https://doaj.org/article/d702a76facc64b9ca3d2316c0276c1b2
Publikováno v:
Nutrients, Vol 14, Iss 24, p 5259 (2022)
Obesity and upper-body fat distribution are independent, cardiometabolic risk factors but whether they also display comparable associations with cancer risk is unknown. We investigated the causal relationships between body mass index (BMI) and BMI-ad
Externí odkaz:
https://doaj.org/article/4cb7c48f7f304f2688b326dd2381f903
Autor:
Nellie Y. Loh, James E. N. Minchin, Katherine E. Pinnick, Manu Verma, Marijana Todorčević, Nathan Denton, Julia El-Sayed Moustafa, John P. Kemp, Celia L. Gregson, David M. Evans, Matt J. Neville, Kerrin S. Small, Mark I. McCarthy, Anubha Mahajan, John F. Rawls, Fredrik Karpe, Constantinos Christodoulides
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Genetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 i
Externí odkaz:
https://doaj.org/article/63058441426945e38b49d38d86552953
Autor:
Costantinos Christodoulides, Inge Verkouter, Dennis O. Mook-Kanamori, Frits R. Rosendaal, Fredrik Karpe, Nellie Y. Loh, Peter L. Zock, Renée de Mutsert, Saskia le Cessie, Raymond Noordam, Ko Willems van Dijk
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology and Metabolism 106 (2021) 11
Journal of Clinical Endocrinology and Metabolism, 106(11), E4438-E4447. ENDOCRINE SOC
Journal of Clinical Endocrinology and Metabolism, 106(11), E4438-E4447
Journal of Clinical Endocrinology and Metabolism 106 (2021) 11
Journal of Clinical Endocrinology and Metabolism, 106(11), E4438-E4447. ENDOCRINE SOC
Journal of Clinical Endocrinology and Metabolism, 106(11), E4438-E4447
Context Weight gain during adulthood increases cardiometabolic disease risk, possibly through adipocyte hypertrophy. Objective We aimed to study the specific metabolomic profile of adult weight gain, and to examine its association with adipocyte volu
Autor:
Manu Verma, Nellie Y. Loh, Rugivan Sabaratnam, Senthil K. Vasan, Andrea D. van Dam, Marijana Todorčević, Matthew J. Neville, Enrique Toledo, Fredrik Karpe, Constantinos Christodoulides
Publikováno v:
Metabolism. 133:155240
Introduction Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo stu
Publikováno v:
Aging Cell
Aging Cell, 20(8). WILEY
Aging Cell, 20(8). WILEY
Observational studies have revealed associations between short leucocyte telomere length (LTL), a TL marker in somatic tissues and multiple Metabolic Syndrome (MetS) traits. Animal studies have supported these findings by showing that increased telom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f138f6196ef413cebeceb659dc235eb3
https://hdl.handle.net/1887/3279580
https://hdl.handle.net/1887/3279580
Autor:
James E.N. Minchin, John F. Rawls, Julia El Sayed Moustafa, Nathan Denton, Fredrik Karpe, Marijana Todorčević, Constantinos Christodoulides, John P. Kemp, Nellie Y. Loh, David M. Evans, Anubha Mahajan, Mark I. McCarthy, Manu Verma, Celia L Gregson, Matt J. Neville, Kerrin S. Small, Katherine E. Pinnick
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loh, N Y, Minchin, J E N, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J, P. Kemp, J, Gregson, C L, Evans, D M, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Loh, N Y, Minchin, JE, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J S, Kemp, J P, Gregson, C L, Evans, D, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. (2020) 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loh, N Y, Minchin, J E N, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J, P. Kemp, J, Gregson, C L, Evans, D M, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Loh, N Y, Minchin, JE, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J S, Kemp, J P, Gregson, C L, Evans, D, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. (2020) 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6f2bebf972c47cc7176712a31a5b32
https://ora.ox.ac.uk/objects/uuid:6cb86e0f-cc0e-4bf5-86d7-da85300193e1
https://ora.ox.ac.uk/objects/uuid:6cb86e0f-cc0e-4bf5-86d7-da85300193e1
Autor:
Sander Kooijman, Fredrik Karpe, Nellie Y. Loh, Patrick C.N. Rensen, Raymond Noordam, Boukje C. Eveleens Maarse, Ko Willems van Dijk, Dennis O. Mook-Kanamori, Diana van Heemst, Constantinos Christodoulides, Frits R. Rosendaal
Publikováno v:
Nutrition, Metabolism & Cardiovascular Diseases, 30(12), 2252-2261. ELSEVIER SCI LTD
Context: Outdoor temperature and bright sunlight may directly and/or indirectly modulate systemic metabolism.Objective: We assessed the associations between outdoor temperature and bright sunlight duration with metabolomics.Design: meta-analysis of t
Autor:
Agata Wesolowska-Andersen, Clive Osmond, Matt J. Neville, Senthil K Vasan, Celia L Gregson, M Verma, Nellie Y. Loh, Constantinos Christodoulides, Fredrik Karpe
WNT signalling is a developmental pathway which plays an important role in post-natal bone accrual. We have previously shown, that in addition to exhibiting extreme high bone mass, subjects with rare gain-of-function (GoF) mutations in the WNT co-rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558a185bd1de0278bc985a67909b1c0a
Autor:
Sian E Piret, Christopher T Esapa, Caroline M Gorvin, Rosie Head, Nellie Y Loh, Olivier Devuyst, Gethin Thomas, Steve D M Brown, Matthew Brown, Peter Croucher, Roger Cox, Rajesh V Thakker
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45217 (2012)
Chronic kidney disease (CKD) is characterized by renal fibrosis that can lead to end-stage renal failure, and studies have supported a strong genetic influence on the risk of developing CKD. However, investigations of the underlying molecular mechani
Externí odkaz:
https://doaj.org/article/c9ed65b4c08843b79c4663219b1b6885