Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nellie Mamuya"'
Autor:
Carolyn Discafani, Bernard Dean Johnson, Hwei-Ru Tsou, Edward Rosfjord, Lee M. Greenberger, M. Brawner Floyd, Rachel Davis, Ramaswamy Nilakantan, Fei Ye, W. A. Hallett, Ru Shen, Allan Wissner, Sridhar K. Rabindran, Brian C. Gruber, Marvin F Reich, Elsebe Overbeek, Yu-Fen Wang, Nellie Mamuya, Xiaoqing Shi
Publikováno v:
Journal of Medicinal Chemistry. 46:49-63
A series of of 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile derivatives that function as irreversible inhibitors of EGFR and HER-2 kinases have been prepared. These inhibitors have, at the 6-position, butynamide, crotonamide, and methacrylamid
Autor:
Bernard Dean Johnson, Carolyn Discafani, Allan Wissner, Hwei-Ru Tsou, Rachel Davis, Brian C. Gruber, Fei Ye, Frank E. Koehn, Lee M. Greenberger, Ramaswamy Nilakantan, Ronald Deblanc, Ru Shen, Marvin F Reich, Nellie Mamuya, Yu-Fen Wang
Publikováno v:
Journal of medicinal chemistry. 44(17)
A series of new 6-substituted-4-(3-bromophenylamino)quinazoline derivatives that may function as irreversible inhibitors of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases have been prepared
Autor:
Zhang Nan, Nellie Mamuya, Hwei-Ru Tsou, Allan Wissner, Diane H. Boschelli, M. B. Floyd, Bernard Dean Johnson, Biqi Wu, Fei Ye, Yu Feng Wang, Dan Maarten Berger, E. Upeslacis, Ramaswamy Nilakantan, Ru Shen, Lee M. Greenberger, Brian C. Gruber, Marvin F Reich
Publikováno v:
Journal of medicinal chemistry. 43(17)
The synthesis and SAR of a series of 4-anilino-6, 7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor (EGF-R) kinase are described. Condensation of 3, 4-dialkoxyanilines with ethyl (ethoxymethylene)cyanoacetate followed