Aberrant Mitochondrial Morphology and Function in the BTBR Mouse Model of Autism Is Improved by Two Weeks of Ketogenic Diet

Autor: Timothy E. Shutt, Rasha Sabouny, Nellie C. Yee, Jong M. Rho, Golam M. Uddin, Bianca R. Villa, Richelle Mychasiuk, Younghee Ahn

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 9
International journal of molecular sciences, vol 21, iss 9
International Journal of Molecular Sciences, Vol 21, Iss 3266, p 3266 (2020)

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder that exhibits a common set of behavioral and cognitive impairments. Although the etiology of ASD remains unclear, mitochondrial dysfunction has recently emerged as a pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd8e7c13bcd3cc2798d58a2bfa8c1c8

Ketogenic diet leads to O-GlcNAc modification in the BTBR

Autor: Christopher, Newell, Virginia L, Johnsen, Nellie C, Yee, Warren J, Xu, Matthias S, Klein, Aneal, Khan, Jong M, Rho, Jane, Shearer

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease. 1863(9)

Protein O-linked-β-N-acetyl glucosamine (O-GlcNAc) is a post-translational modification to Ser/Thr residues that integrates energy supply with demand. Abnormal O-GlcNAc patterning is evident in several neurological disease states including epilepsy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f28f65e0a3b0170afd6b796c05f0a1f
https://pubmed.ncbi.nlm.nih.gov/28502704