Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Nelita du Plessis"'
Autor:
Andrew Fiore-Gartland, Himangi Srivastava, Aaron Seese, Tracey Day, Adam Penn-Nicholson, Angelique Kany Kany Luabeya, Nelita Du Plessis, Andre G. Loxton, Linda-Gail Bekker, Andreas Diacon, Gerhard Walzl, Zachary K. Sagawa, Steven G. Reed, Thomas J. Scriba, Mark Hatherill, Rhea Coler
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDevelopment of an effective vaccine against tuberculosis is a critical step towards reducing the global burden of disease. A therapeutic vaccine might also reduce the high rate of TB recurrence and help address the challenges of drug-resi
Externí odkaz:
https://doaj.org/article/8bd9fb56ab6546c1bd28acda357be680
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012266 (2024)
Tuberculosis (TB) remains a global public health threat. Understanding the dynamics of host-pathogen interactions within TB granulomas will assist in identifying what leads to the successful elimination of infection. In vitro TB models provide a cont
Externí odkaz:
https://doaj.org/article/8ccf31721ed84bc6b8ab553172a8f81f
Autor:
Jane Alexandra Shaw, Maynard Meiring, Devon Allies, Lauren Cruywagen, Tarryn-Lee Fisher, Kesheera Kasavan, Kelly Roos, Stefan Marc Botha, Candice MacDonald, Andriёtte M. Hiemstra, Donald Simon, Ilana van Rensburg, Marika Flinn, Ayanda Shabangu, Helena Kuivaniemi, Gerard Tromp, Stephanus T. Malherbe, Gerhard Walzl, Nelita du Plessis, The Stellenbosch University Immunology Research Group Bronchoalveolar Lavage Study Consortium (SU IRG BAL Study Consortium)
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Bronchoalveolar lavage (BAL) is becoming a common procedure for research into infectious disease immunology. Little is known about the clinical factors which influence the main outcomes of the procedure. In research participants who underwen
Externí odkaz:
https://doaj.org/article/8f209aacf2af4e1eaddca58ce553bbde
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299107 (2024)
In vitro models of Mycobacterium tuberculosis (Mtb) infection are a valuable tool for examining host-pathogen interactions and screening drugs. With the development of more complex in vitro models, there is a need for tools to help analyze and integr
Externí odkaz:
https://doaj.org/article/fd44b341b0d04eedb0815b2686503dda
Autor:
Jane Alexandra Shaw, Maynard Meiring, Candice Snyders, Frans Everson, Lovemore Nyasha Sigwadhi, Veranyay Ngah, Gerard Tromp, Brian Allwood, Coenraad F. N. Koegelenberg, Elvis M. Irusen, Usha Lalla, Nicola Baines, Annalise E. Zemlin, Rajiv T. Erasmus, Zivanai C. Chapanduka, Tandi E. Matsha, Gerhard Walzl, Hans Strijdom, Nelita du Plessis, Alimuddin Zumla, Novel Chegou, Stephanus T. Malherbe, Peter S. Nyasulu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionBiomarkers predicting mortality among critical Coronavirus disease 2019 (COVID-19) patients provide insight into the underlying pathophysiology of fatal disease and assist with triaging of cases in overburdened settings. However, data des
Externí odkaz:
https://doaj.org/article/295e1df4f3e0462eab40f893a5438ae6
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Epidemiologic data show that both current and previous tuberculosis (TB) increase the risk of in-hospital mortality from coronavirus disease-2019 (COVID-19), and there is a similar trend for poor outcomes from Mycobacterium tuberculosis (Mtb) infecti
Externí odkaz:
https://doaj.org/article/24de355e39484834aab63b3c2c02cc98
Autor:
Andriёtte M. Hiemstra, Candice E. MacDonald, Ilana C. van Rensburg, Kim Stanley, Elizna Maasdorp, Shirley Mc Anda, Susanne Tönsing, Jane Alexandra Shaw, Gerard Tromp, Gian D. van der Spuy, Kevin B. Urdahl, David M. Lewinsohn, Helena Kuivaniemi, Nelita Du Plessis, Stephanus T. Malherbe, Gerhard Walzl
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-22 (2022)
Abstract Background Natural immunity against Mycobacterium tuberculosis exists, and > 90% of those infected remain disease-free. Innate and adaptive immune responses required to mediate such protection against tuberculosis (TB) are, however, poorly u
Externí odkaz:
https://doaj.org/article/51be04ee190543e696b8a5a6d4786f48
Autor:
Vinzeigh N. Leukes, Stephanus T. Malherbe, Andriette Hiemstra, Leigh A. Kotze, Kelly Roos, Alana Keyser, Dalene De Swardt, Andrea Gutschmidt, Gerhard Walzl, Nelita du Plessis
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Successful TB treatment is hampered by increasing resistance to the two most effective first-line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promisin
Externí odkaz:
https://doaj.org/article/c412de5fcccf443887d1b48438fa8307
Autor:
Osagie A. Eribo, Charissa C. Naidoo, Grant Theron, Gerhard Walzl, Nelita du Plessis, Novel N. Chegou
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 451 (2023)
Bacteroides fragilis is a commonly investigated commensal bacterium for its protective role in host diseases. Here, we aimed to develop a reproducible antibiotic-based model for conditioning the gut microbiota and engrafting B. fragilis into a conven
Externí odkaz:
https://doaj.org/article/b0f8f5fe771b4feb85182b89443aea55
Autor:
Leigh Ann Kotze, Gian van der Spuy, Bryan Leonard, Adam Penn-Nicholson, Munyaradzi Musvosvi, Shirley McAnda, Stephanus T. Malherbe, Mzwandile Erasmus, Thomas Scriba, Coenraad F. N. Koegelenberg, Brian W. Allwood, Gerhard Walzl, Nelita du Plessis
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Myeloid-derived suppressor cells (MDSC) have been identified in the peripheral blood and granulomas of patients with active TB disease, but their phenotype-, function-, and immunosuppressive mechanism- spectrum remains unclear. Importantly, the frequ
Externí odkaz:
https://doaj.org/article/e20a5a117b5e45b88563e406f947afea