Výsledky vyhledávání - "Nelfinavir mesylate"

Autor: Ahmed Refaat Gardouh, Norehan Ghourab, Shadeed Gad, Yasser M. Moustafa

Publikováno v: Records of Pharmaceutical and Biomedical Sciences. 4:17-31

Nanosponges are colloidal carriers that potentially improve the aqueous solubility of poorly water-soluble drug, retarding its release, improving bioavailability, enhancing physical and chemical stability and decrease skin irritation as well. In addi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::959c325a3f37ae8a24fcec3e18900abd
https://doi.org/10.21608/rpbs.2019.17076.1041

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Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen

Autor: Jordi Rodon, Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Marc Noguera-Julian, Roger Paredes, Lourdes Mateu, Carles Quiñones, Carles Perez, Itziar Erkizia, Ignacio Blanco, Alfonso Valencia, Víctor Guallar, Jorge Carrillo, Julià Blanco, Joaquim Segalés, Bonaventura Clotet, Júlia Vergara-Alert, Nuria Izquierdo-Useros

Publikováno v: Frontiers in Pharmacology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Frontiers in Pharmacology, Vol 12 (2021)
IRTA Pubpro. Open Digital Archive
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, their efficacy is still under evaluation. Here, we

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A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus

Autor: Urs F. Greber, Fabien Kuttler, Gerardo Turcatti, Artur Yakimovich, Robert Witte, Luca Murer, Fanny Georgi, Vardan Andriasyan

Publikováno v: Scientific Data, Vol 7, Iss 1, Pp 1-12 (2020)
Scientific Data

Human adenoviruses (HAdVs) are fatal to immuno-suppressed individuals, but no effective anti-HAdV therapy is available. Here, we present a novel image-based high-throughput screening (HTS) platform, which scores the full viral replication cycle from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471893b3a49d8cc948220b73c7879a87
https://doi.org/10.5167/uzh-189139

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The anti‐HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV‐2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID‐19 infections

Autor: Farhana Musarrat, Vladimir N. Chouljenko, Konstantin G. Kousoulas, Tamara Chouljenko, Achyut Dahal, Seetharama D. Jois, Rafiq Nabi

Publikováno v: Journal of Medical Virology

Severe acute respiratory syndrome coronavirus‐2 (SARS CoV‐2) is the causative agent of the coronavirus disease‐2019 (COVID‐19) pandemic. Coronaviruses enter cells via fusion of the viral envelope with the plasma membrane and/or via fusion of

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The FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of human adenoviruses

Autor: Nicole Meili, Fanny Georgi, Luca Murer, Urs F. Greber, Robert Witte, Lisa Yu, Gerardo Turcatti, Artur Yakimovich, Melanie Grove, Vardan Andriasyan, Silvio Hemmi, Fabien Kuttler

Adenoviruses (AdVs) are prevalent and give rise to chronic and recurrent disease. The human AdV (HAdV) species B and C, such as HAdV-C2, C5 and B14, cause respiratory disease, and constitute a health threat for immuno-compromised individuals. HAdV-Cs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56f026ef9d467cf38d23c149f0a77e81
https://doi.org/10.1101/2020.05.15.098061

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Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect after a Drug Repurposing Screen

Autor: Victor Guallar, Roger Paredes, Jordi Rodon, Daniel Perez-Zsolt, Carles Quiñones, Itziar Erkizia, Lourdes Mateu, Julià Blanco, Ignacio Blanco, Alfonso Valencia, Jorge Carrillo, Nuria Izquierdo-Useros, Júlia Vergara-Alert, Marc Noguera-Julian, Jordana Muñoz-Basagoiti, Bonaventura Clotet, Joaquim Segalés

There is an urgent need to identify therapeutics for the treatment of Coronavirus diseases 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, their efficacy is still under evaluation. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c04ebdb48ce09d5c96d08ebe43ed52e0
https://doi.org/10.1101/2020.04.23.055756

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The anti-HIV Drug Nelfinavir Mesylate (Viracept) is a Potent Inhibitor of Cell Fusion Caused by the SARS-CoV-2 Spike (S) Glycoprotein Warranting further Evaluation as an Antiviral against COVID-19 infections

Autor: Rafiq Nabi, Farhana Musarrat, Seetharama D. Jois, Achyut Dahal, Konstantin G. Kousoulas, Vladimir N. Chouljenko

Coronaviruses belong to a group of enveloped, positive-single stranded RNA viruses that are known to cause severe respiratory distress in animals and humans. The current SARS coronavirus-2 (SARS CoV-2) pandemic has caused more than 2,000,000 infectio

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https://doi.org/10.1101/2020.04.24.060376

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Nelfinavir Is Active Against SARS-CoV-2 in Vero E6 Cells

Autor: Weiliang Zhu, Xiangyun Lu, Jingshan Shen, Li Lanjuan, Nanping Wu, Yechun Xu, Zhijian Xu, Yao Hangping

Utilizing an integrative computational drug discovery approach, we predicted that nelfinavir is a potential inhibitor of SARS-CoV-2 main protease. Further docking nelfinavir to 30 potential target proteins of COVID-19, we found that nelfinavir is mos

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https://doi.org/10.26434/chemrxiv.12039888

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