Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate.

Autor: Vidal-Calvo EE; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. elena@sund.ku.dk.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. elena@sund.ku.dk., Martin-Salazar A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Choudhary S; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Dagil R; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Raghavan SSR; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Duvnjak L; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Nordmaj MA; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Clausen TM; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Skafte A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Oberkofler J; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Wang K; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Agerbæk MØ; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VARCT Diagnostics, Copenhagen, Denmark., Løppke C; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Jørgensen AM; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VARCT Diagnostics, Copenhagen, Denmark., Ropac D; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Mujollari J; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Willis S; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Garcias López A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Miller RL; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Karlsson RTG; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Goerdeler F; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Chen YH; GlycoDisplay ApS, Copenhagen, Denmark., Colaço AR; Proteomics Research Infrastructure, University of Copenhagen, Copenhagen, Denmark., Wang Y; College of Life Sciences, Zhejiang University, Hangzhou, China., Lavstsen T; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Martowicz A; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria., Nelepcu I; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Marzban M; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Oo HZ; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Ørum-Madsen MS; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Wang Y; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Nielsen MA; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Clausen H; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wierer M; Proteomics Research Infrastructure, University of Copenhagen, Copenhagen, Denmark., Wolf D; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria., Gögenur I; Center for Surgical Science, Department of Surgery, Zealand University Hospital Køge, Køge, Denmark., Theander TG; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Al-Nakouzi N; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Gustavsson T; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Daugaard M; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. mads.daugaard@ubc.ca.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada. mads.daugaard@ubc.ca.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. mads.daugaard@ubc.ca., Salanti A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. salanti@sund.ku.dk.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. salanti@sund.ku.dk.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 30; Vol. 15 (1), pp. 7553. Date of Electronic Publication: 2024 Aug 30.

Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer.

Autor: Al-Nakouzi N; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada. nalnakouzi@prostatecentre.com.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada. nalnakouzi@prostatecentre.com., Wang CK; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Oo HZ; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Nelepcu I; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Lallous N; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Spliid CB; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Khazamipour N; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Lo J; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Truong S; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Collins C; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Hui D; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Esfandnia S; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Adomat H; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Clausen TM; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Gustavsson T; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2pharmaceuticals Ole Maaløes Vej 3, 2200, København, Denmark., Choudhary S; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2pharmaceuticals Ole Maaløes Vej 3, 2200, København, Denmark., Dagil R; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2pharmaceuticals Ole Maaløes Vej 3, 2200, København, Denmark., Corey E; Department of Urology, University of Washington, Seattle, WA, 98195, USA., Wang Y; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Chauchereau A; Prostate Cancer Group, INSERM UMR981, Gustave Roussy, University of Paris-Saclay, F-94805, Villejuif, France., Fazli L; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Esko JD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Salanti A; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, Copenhagen, Denmark., Nelson PS; Department of Urology, University of Washington, Seattle, WA, 98195, USA.; Fred Hutchinson Cancer Centre, Seattle, WA, 98109-1024, USA., Gleave ME; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada., Daugaard M; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada. mads.daugaard@ubc.ca.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada. mads.daugaard@ubc.ca.

Publikováno v: Nature communications [Nat Commun] 2022 Aug 13; Vol. 13 (1), pp. 4760. Date of Electronic Publication: 2022 Aug 13.

Regulation of PPARγ expression in luminal muscle invasive bladder cancer

Autor: Tortora, D, Morgan, R, Kumar, G, Ritch, E, McConeghy, B, Sinha, S, Johnson, A, Wong, J, Thaper, D, Truong, S, Nelepcu, I, Black, P, Daugaard, M

Publikováno v: In Urologic Oncology: Seminars and Original Investigations December 2020 38(12):905-905

Peptide-Drug Conjugates: A New Hope for Cancer Management.

Autor: Chavda, Vivek P.¹ (AUTHOR) vivek.chavda@lmcp.ac.in, Solanki, Hetvi K.¹ (AUTHOR), Davidson, Majid² (AUTHOR), Apostolopoulos, Vasso^2,3 (AUTHOR) vivek.chavda@lmcp.ac.in, Bojarska, Joanna⁴ (AUTHOR) vivek.chavda@lmcp.ac.in

Publikováno v: Molecules. Nov2022, Vol. 27 Issue 21, p7232. 28p.

The Alterations and Roles of Glycosaminoglycans in Human Diseases.

Autor: Wang, Qingchi, Chi, Lianli

Publikováno v: Polymers (20734360); Nov2022, Vol. 14 Issue 22, p5014, 26p