Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatmentResearch in context

Autor: Ray W. Izquierdo-Lara, Nele Villabruna, Dennis A. Hesselink, Claudia M.E. Schapendonk, Sol Ribó Pons, David Nieuwenhuijse, Jenny I.J. Meier, Ian Goodfellow, Virgil A.S.H. Dalm, Pieter L.A. Fraaij, Jeroen J.A. van Kampen, Marion P.G. Koopmans, Miranda de Graaf

Publikováno v: EBioMedicine, Vol 109, Iss , Pp 105391- (2024)

Summary: Background: Currently, there is no licensed treatment for chronic norovirus infections, but the use of intra-duodenally-delivered immunoglobulins is promising; nevertheless, varying results have limited their wide use. Little is known about

Externí odkaz: https://doaj.org/article/56a68a0132fe45dd9ced3cdeb5c4fdac

Phylogenetic Investigation of Norovirus Transmission between Humans and Animals

Autor: Nele Villabruna, Ray W. Izquierdo Lara, Judit Szarvas, Marion P. G. Koopmans, Miranda de Graaf

Publikováno v: Viruses, Vol 12, Iss 11, p 1287 (2020)

Norovirus infections are a leading cause of acute gastroenteritis worldwide, affecting people of all ages. There are 10 norovirus genogroups (GI-GX) that infect humans and animals in a host-specific manner. New variants and genotypes frequently emerg

Externí odkaz: https://doaj.org/article/c98605ac0c3a4ef5863be04b0e3f854d

Clinical and In Vitro Evidence Favoring Immunoglobulin Treatment of a Chronic Norovirus Infection in a Patient With Common Variable Immunodeficiency

Autor: Jeroen J A van Kampen, Virgil A S H Dalm, Pieter L A Fraaij, Bas B Oude Munnink, Claudia M E Schapendonk, Ray W Izquierdo-Lara, Nele Villabruna, Khalil Ettayebi, Mary K Estes, Marion P G Koopmans, Miranda de Graaf

Publikováno v: The Journal of infectious diseases, 226(10), 1781-1789. Oxford University Press

Background Immunocompromised individuals can become chronically infected with norovirus, but effective antiviral therapies are not yet available. Methods Treatments with nitazoxanide, ribavirin, interferon alpha-2a, and nasoduodenally administered im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5556e07d16c301cefa27445a2a1f7d1
https://pure.eur.nl/en/publications/962c4435-86da-41ec-bc23-9e02c693db33

Phylogenetic Investigation of Norovirus Transmission between Humans and Animals

Autor: Ray W. Izquierdo Lara, Miranda de Graaf, Judit Szarvas, Marion Koopmans, Nele Villabruna

Publikováno v: Viruses, Vol 12, Iss 1287, p 1287 (2020)
Villabruna, N, Izquierdo Lara, R W, Szarvas, J, Koopmans, M P G & de Graaf, M 2020, ' Phylogenetic Investigation of Norovirus Transmission between Humans and Animals ', Viruses, vol. 12, no. 11, 1287 . https://doi.org/10.3390/v12111287
Viruses
Volume 12
Issue 11
Viruses, 12(11). Multidisciplinary Digital Publishing Institute (MDPI)

Norovirus infections are a leading cause of acute gastroenteritis worldwide, affecting people of all ages. There are 10 norovirus genogroups (GI-GX) that infect humans and animals in a host-specific manner. New variants and genotypes frequently emerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81009ff47d02db0cebcfbc74eacede58
https://doi.org/10.3390/v12111287

Animals as Reservoir for Human Norovirus

Autor: Nele Villabruna, Miranda de Graaf, Marion Koopmans

Publikováno v: Viruses
Viruses, Vol 11, Iss 5, p 478 (2019)
Viruses-Basel, 11(5):478. Multidisciplinary Digital Publishing Institute (MDPI)

Norovirus is the most common cause of non-bacterial gastroenteritis and is a burden worldwide. The increasing norovirus diversity is currently categorized into at least 10 genogroups which are further classified into more than 40 genotypes. In additi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92208cd83629cd058e771cf3dfb3f033