Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nele Vandervoort"'
Autor:
L. Lepescheux, R. Gosmini, F. De Ceuninck, Thierry Christophe, E. van der Aar, I. Botez, Nele Vandervoort, Pierre Deprez, D. Amantini, Roland Blanque, D. Merciris, Robert Touitou, Philippe Clément-Lacroix, C. Cottereaux, S. Meurisse, Patrick Mollat, F. Brebion, D. Comas, Christopher B. Little, Margaret M. Smith
Publikováno v:
Osteoarthritis and Cartilage. 30:291-301
Summary Objective A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a key enzyme in degradation of cartilage in osteoarthritis (OA). We report the pharmacological characterization of GLPG1972/S201086, a new, potent and sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3703c4b9781633c63762275b997650
https://doi.org/10.1016/j.joca.2021.08.012
https://doi.org/10.1016/j.joca.2021.08.012
Autor:
Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto
Publikováno v:
Journal of Medicinal Chemistry. 64:2937-2952
There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs). The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan (AGC), a component of cartilage. Therefore, ADAMTS-5 is a promising target for the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63e1d09bcd2c3ffc719892459e89ab3
https://doi.org/10.1021/acs.jmedchem.0c02008
https://doi.org/10.1021/acs.jmedchem.0c02008
Autor:
Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera
Publikováno v:
Journal of Medicinal Chemistry. 63:13526-13545
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f803bd9662806c89d70fe1a829f85
https://doi.org/10.1021/acs.jmedchem.0c00272
https://doi.org/10.1021/acs.jmedchem.0c00272
Autor:
Frédéric, Labéguère, Sonia, Dupont, Luke, Alvey, Florilène, Soulas, Gregory, Newsome, Amynata, Tirera, Vanessa, Quenehen, Thi Thu Trang, Mai, Pierre, Deprez, Roland, Blanqué, Line, Oste, Sandrine, Le Tallec, Steve, De Vos, Annick, Hagers, Ann, Vandevelde, Luc, Nelles, Nele, Vandervoort, Katja, Conrath, Thierry, Christophe, Ellen, van der Aar, Emanuelle, Wakselman, Didier, Merciris, Céline, Cottereaux, Cécile, da Costa, Laurent, Saniere, Philippe, Clement-Lacroix, Laura, Jenkins, Graeme, Milligan, Stephen, Fletcher, Reginald, Brys, Romain, Gosmini
Publikováno v:
Journal of medicinal chemistry. 63(22)
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dca817b6050468a00027ab8ce9b149c4
https://pubmed.ncbi.nlm.nih.gov/32902984
https://pubmed.ncbi.nlm.nih.gov/32902984
Autor:
Christelle David, Nele Vandervoort, Damien Fleury, Denis Annoot, Laëtitia Cherel, Willem Jan Hengeveld, Thierry Christophe, Sameh H. Soror, Agnès Marie Joncour, Christopher Gaëtan Housseman, Alain Monjardet, R Galien, Patrick Mollat, Reginald Brys, Veronique Roncoroni, Luce Lepissier, Natacha Bienvenu, Lionel Vercheval, Alexandre Wohlkonig, Christophe Peixoto, Jörg Heiermann, Katja Conrath, Mia Jans, Sandrine Le Tallec, Bertrand Heckmann, Robert Touitou, Nicolas Desroy, Jan Steyaert, Virginie Labeguere, Gregor Pilzak, Ellen van der Aar, Xavier Marie Bock, Nicolas Triballeau, Emanuelle Wakselman
Publikováno v:
Journal of Medicinal Chemistry. 60:7371-7392
Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis of lysophosphatidyl choline (LPC). The ATX-LPA signaling axis arouses a high interest in the drug discovery industr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bab957aedfbab6da364d90d0e33f16
https://doi.org/10.1021/acs.jmedchem.7b00647
https://doi.org/10.1021/acs.jmedchem.7b00647
Autor:
E. van der Aar, L. Lepescheux, I. Botez, Thierry Christophe, F. Brebion, Pierre Deprez, Roland Blanque, D. Merciris, S. Meurisse, Monica Borgonovi, R. Gosmini, F. De Ceuninck, Patrick Mollat, Philippe Clément-Lacroix, D. Comas, Nele Vandervoort, C. Cottereaux, D. Amantini
Publikováno v:
FRIDAY, 15 JUNE 2018.
Background Aggrecan cleavage is an early process in cartilage degradation observed in OA. As a result, aggrecanase inhibition is an attractive therapeutic strategy for the treatment of OA.1 2 A disintegrin and metalloproteinase with thrombospondin mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740fa263bcd0d73ca8948c97a8e26acf
https://doi.org/10.1136/annrheumdis-2018-eular.2610
https://doi.org/10.1136/annrheumdis-2018-eular.2610
Autor:
R. Gosmini, E. van der Aar, Pierre Deprez, Roland Blanque, Thierry Christophe, L. Lepescheux, Christopher B. Little, Philippe Clément-Lacroix, F. Brebion, C. Cottereaux, D. Amantini, I. Botez, Patrick Mollat, D. Comas, Nele Vandervoort, F. De Ceuninck, S. Meurisse
Publikováno v:
Oral Presentations.
Background Degradation of articular cartilage and alterations of the underlying subchondral bone are hallmarks of osteoarthritis (OA) 1 . A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) is a key aggrecan-cleaving enzyme in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9202796e0b4780d3509f8d554349e78c
https://doi.org/10.1136/annrheumdis-2017-eular.3775
https://doi.org/10.1136/annrheumdis-2017-eular.3775
Autor:
Nele Vandervoort, Xavier Marie Bock, Patrick Mollat, Jovica Ralić, Alain Monjardet, Nicolas Triballeau, Thierry Christophe, Ellen van der Aar, Marieke Lamers, Boska Hrvacic, Nicolas Desroy, Bertrand Heckmann, Line Oste, Emilie Rondet, Virginie Labeguere, Roland Blanque, Veronique Roncoroni, Christopher Gaëtan Housseman, Sandrine Le Tallec, Natacha Bienvenu, C. Cottereaux, M. Auberval, Reginald Brys, Laëtitia Cherel, Emanuelle Wakselman, Picolet Olivier Laurent, Jean-Marie Grassot, Agnès Marie Joncour, Christophe Peixoto, Denis Annoot
Autotaxin is a circulating enzyme with a major role in the production of lysophosphatic acid (LPA) species in blood. A role for the autotaxin/LPA axis has been suggested in many disease areas including pulmonary fibrosis. Structural modifications of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c6f6e80895c7ca93e77aad9243c383
https://www.bib.irb.hr/981523
https://www.bib.irb.hr/981523
Autor:
C. Cottereaux, R. Gosmini, E. van der Aar, D. Amantini, Nele Vandervoort, L. Lepescheux, Patrick Mollat, D. Comas, Pierre Deprez, Roland Blanque, Thierry Christophe, F. Brebion, Christopher B. Little, I. Botez, Philippe Clément-Lacroix, F. De Ceuninck, S. Meurisse
Publikováno v:
Osteoarthritis and Cartilage. 25:S58-S59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ea7e1f012cfa0b4d04832d440fb14
https://doi.org/10.1016/j.joca.2017.02.106
https://doi.org/10.1016/j.joca.2017.02.106
Autor:
Reginald Brys, Emanuelle Wakselman, Lionel Vercheval, Christelle David, Nele Vandervoort, Laëtitia Cherel, Christopher Gaëtan Housseman, Luce Lepissier, Natacha Bienvenu, Mia Jans, Alain Monjardet, Agnès Marie Joncour, Nicolas Desroy, Gregor Pilzak, Willem Jan Hengeveld, Sandrine Le Tallec, Ellen van der Aar, Bertrand Heckmann, Nicolas Triballeau, Jan Steyaert, Patrick Mollat, Veronique Roncoroni, Virginie Labeguere, Sameh H. Soror, Damien Fleury, Thierry Christophe, Christophe Peixoto, Xavier Marie Bock, Denis Annoot, Jörg Heiermann, Katja Conrath, R Galien, Robert Touitou, Alexandre Wohlkonig
Publikováno v:
Journal of Medicinal Chemistry. 61:4270-4270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dee812f5866eca6cabf47d605a46ce
https://doi.org/10.1021/acs.jmedchem.8b00579
https://doi.org/10.1021/acs.jmedchem.8b00579