Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Nele Vandersickel"'
Autor:
Arstanbek Okenov, Timur Nezlobinsky, Katja Zeppenfeld, Nele Vandersickel, Alexander V Panfilov
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0300978 (2024)
Cardiac fibrosis stands as one of the most critical conditions leading to lethal cardiac arrhythmias. Identifying the precise location of cardiac fibrosis is crucial for planning clinical interventions in patients with various forms of ventricular an
Externí odkaz:
https://doaj.org/article/228843e38c0348f790a5d7a41b74bf65
Autor:
Robin Van Den Abeele, Sander Hendrickx, Enid Van Nieuwenhuyse, Albert Dunnink, Alexander V. Panfilov, Marc A. Vos, Eike M. Wülfers, Nele Vandersickel
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Torsade de Pointes is a polymorphic ventricular tachycardia which is as yet incompletely understood. While the onset of a TdP episode is generally accepted to be caused by triggered activity, the mechanisms for the perpetuation is still under debate.
Externí odkaz:
https://doaj.org/article/467a02e268dc436187235e4d4c72ce17
Autor:
Nele Vandersickel, Enid Van Nieuwenhuyse, Nico Van Cleemput, Jan Goedgebeur, Milad El Haddad, Jan De Neve, Anthony Demolder, Teresa Strisciuglio, Mattias Duytschaever, Alexander V. Panfilov
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Networks provide a powerful methodology with applications in a variety of biological, technological and social systems such as analysis of brain data, social networks, internet search engine algorithms, etc. To date, directed networks have not yet be
Externí odkaz:
https://doaj.org/article/a4552fcf30cf4d3f9cf98fa434111c99
Autor:
Nele Vandersickel, Masaya Watanabe, Qian Tao, Jan Fostier, Katja Zeppenfeld, Alexander V Panfilov
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006637 (2018)
Rotors are functional reentry sources identified in clinically relevant cardiac arrhythmias, such as ventricular and atrial fibrillation. Ablation targeting rotor sites has resulted in arrhythmia termination. Recent clinical, experimental and modelli
Externí odkaz:
https://doaj.org/article/f3b9e6ce75cf49b5b1fdc7aa83bfda1f
Autor:
Alessio Lissoni, Nan Wang, Timur Nezlobinskii, Maarten De Smet, Alexander V. Panfilov, Nele Vandersickel, Luc Leybaert, Katja Witschas
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7340 (2020)
Cx43 hemichannels (HCs) are electrically and chemically gated transmembrane pores with low open probability and multiple conductance states, which makes kinetic studies of channel gating in large datasets challenging. Here, we developed open access s
Externí odkaz:
https://doaj.org/article/41c79c6488254f5f94eb4df4e229f706
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we pre
Externí odkaz:
https://doaj.org/article/b7f2871c5bc640048197b0a12d74b80d
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188867 (2017)
Early Afterdepolarizations, EADs, are defined as the reversal of the action potential before completion of the repolarization phase, which can result in ectopic beats. However, the series of mechanisms of EADs leading to these ectopic beats and relat
Externí odkaz:
https://doaj.org/article/d80b9ebc54554cc9bd22ce562bca6aac
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130632 (2015)
Early afterdepolarizations (EADs), which are abnormal oscillations of the membrane potential at the plateau phase of an action potential, are implicated in the development of cardiac arrhythmias like Torsade de Pointes. We carry out extensive numeric
Externí odkaz:
https://doaj.org/article/5db1f517252f45c5bd8b5d16e7bcd676
Autor:
Nele Vandersickel, Ivan V. Kazbanov, Anita Nuitermans, Louis D. Weise, Rahul Pandit, Alexander V. Panfilov
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/25eb1093acf441179a1ead0514333f2d
Autor:
Nele Vandersickel, Ivan V Kazbanov, Anita Nuitermans, Louis D Weise, Rahul Pandit, Alexander V Panfilov
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84595 (2014)
Sudden cardiac death is often caused by cardiac arrhythmias. Recently, special attention has been given to a certain arrhythmogenic condition, the long-QT syndrome, which occurs as a result of genetic mutations or drug toxicity. The underlying mechan
Externí odkaz:
https://doaj.org/article/c152f28370684a5597c6d9ad7795166d