Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Nele Vandeputte"'
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Akademický článek
Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura
Autor: Elien Roose, Claudia Tersteeg, Ruth Demeersseman, An-Sofie Schelpe, Louis Deforche, Inge Pareyn, Aline Vandenbulcke, Nele Vandeputte, Daan Dierickx, Jan Voorberg, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke
Publikováno v: TH Open, Vol 02, Iss 01, Pp e8-e15 (2018)
Abstract In this study, we investigated a case of pregnancy-onset thrombotic thrombocytopenic purpura (TTP). The patient had severely decreased ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) activity levels d
Externí odkaz: https://doaj.org/article/1e8e322e788b4091aebd010e59ffcefd
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2
Akademický článek
Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.
Autor: Louis Deforche, Claudia Tersteeg, Elien Roose, Aline Vandenbulcke, Nele Vandeputte, Inge Pareyn, Elien De Cock, Hanspeter Rottensteiner, Hans Deckmyn, Simon F De Meyer, Karen Vanhoorelbeke
Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160388 (2016)
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy linked to a deficiency in the metalloprotease ADAMTS13. In the current study, a novel mouse model for acquired TTP was generated to facilitate development and
Externí odkaz: https://doaj.org/article/f1966b3c66014898b88b297e085fb9e8
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3
von Willebrand factor in experimental malaria‐associated acute respiratory distress syndrome
Autor: Hans Deckmyn, Sirima Kraisin, Philippe E. Van den Steen, Claudia Tersteeg, Kimberly Martinod, Sebastien Verhenne, Karen Vanhoorelbeke, Simon F. De Meyer, Thao-Thy Pham, Nele Vandeputte
Publikováno v: Journal of Thrombosis and Haemostasis
BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a lethal complication of severe malaria, characterized by marked pulmonary inflammation. Patient studies have suggested a link between von Willebrand factor (VWF) and mal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5970944d8f3506900e22acd6c940c6c6
https://doi.org/10.1111/jth.14485
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4
High and long‐term von Willebrand factor expression after Sleeping Beauty transposon‐mediated gene therapy in a mouse model of severe von Willebrand disease
Autor: Irina Portier, Inge Pareyn, D. S. Goldenberg, Zoltán Ivics, Sebastien Verhenne, Hans Deckmyn, Zsuzsanna Izsvák, Himanshu Bhusan Samal, S. F. De Meyer, Nele Vandeputte, Karen Vanhoorelbeke, Manvendra K. Singh
Publikováno v: Journal of Thrombosis and Haemostasis. 16:592-604
Essentials von Willebrand disease (VWD) is the most common inherited bleeding disorder. Gene therapy for VWD offers long-term therapy for VWD patients. Transposons efficiently integrate the large von Willebrand factor (VWF) cDNA in mice. Liver-direct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76f88c7eb9e2d043577d52a522a02a8
https://doi.org/10.1111/jth.13938
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5
Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy
Autor: Zsuzsanna Izsvák, Inge Pareyn, Sebastien Verhenne, Hanspeter Rottensteiner, Karen Vanhoorelbeke, Simon F. De Meyer, Hans Deckmyn, Nele Vandeputte
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 37:836-844
Objective— Severe deficiency in the von Willebrand factor–cleaving protease ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) because of mutations in the ADAMTS13 gene can lead to acute episodes of congeni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d785287411cfa6dd4fcd1f924089d0
https://doi.org/10.1161/atvbaha.116.308680
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7
von Willebrand factor deficiency does not influence angiotensin II-induced abdominal aortic aneurysm formation in mice
Autor: Irina Portier, Hans Deckmyn, Nele Vandeputte, Linda Desender, Simon F. De Meyer, Kimberly Martinod, Karen Vanhoorelbeke
Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abdominal aortic aneurysm (AAA) refers to a localized dilation of the abdominal aorta that exceeds the normal diameter by 50%. AAA pathophysiology is characterized by progressive inflammation, vessel wall destabilization and thrombus formation. Our a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953016967b05c40fc4ee3249f40a3b3c
https://doi.org/10.1038/s41598-018-35029-8
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9
Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13
Autor: Elien Roose, Karen Vanhoorelbeke, Inge Pareyn, Nele Vandeputte, Leydi Carolina Velásquez Pereira, Gerry A. F. Nicolaes, Bogac Ercig, Hans Deckmyn, Kristin Jochmans, Karel Fostier, Chloë Geeroms, An-Sofie Schelpe, Christelle Orlando, Simon F. De Meyer
Publikováno v: European Journal of Haematology
European journal of haematology, 101(2), 191-199. Wiley-Blackwell
European Journal of Haematology, 101(2), 191-199. Wiley
INTRODUCTION: Patients suffering from congenital thrombotic thrombocytopenic purpura (cTTP) have a deficiency in ADAMTS13 due to mutations in their ADAMTS13 gene. OBJECTIVE: The aim of this study was to determine ADAMTS13 parameters (activity, antige
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1665fce5c0892124933b74406de30c4
https://pubmed.ncbi.nlm.nih.gov/29763513
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10
Open ADAMTS13 Conformation in Immune-Mediated Thrombotic Thrombocytopenic Purpura Is Induced By Anti-ADAMTS13 Autoantibodies and Corresponds with an Ongoing ADAMTS13 Pathology
Autor: Elien Roose, György Sinkovits, Rob Fijnheer, Paul Coppo, Andreas Greinacher, Agnès Veyradier, Gilles Kaplanski, Maelle Le Besnerais, Zoltán Prohászka, Jan Voorberg, Hans Deckmyn, Edwige Tellier, Nele Vandeputte, Inge Pareyn, Karen Vanhoorelbeke, Ilaria Mancini, Flora Peyvandi, Ygal Benhamou, Simon F. De Meyer, Aline Vandenbulcke, An-Sofie Schelpe
Publikováno v: Blood
Blood, 2018, 132 (1), ⟨10.1182/blood-2018-99-113762⟩
60. Annual Meeting of the American-Society-of-Hematology (ASH)
60. Annual Meeting of the American-Society-of-Hematology (ASH), American Society of Hematology (ASH). USA., Dec 2018, San Diego, CA, United States. pp.3, ⟨10.1182/blood-2018-99-113762⟩
Blood, American Society of Hematology, 2018, 132 (1), ⟨10.1182/blood-2018-99-113762⟩
Background. Deficient ADAMTS13 activity (TS13:act 50%. However, also iTTP patients in remission with a persistent ( Aim. Determine ADAMTS13 conformation in plasma of iTTP patients during acute TTP and remission when TS13:act is 50% and investigate if
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4faacc327c41872b8a3a99e2396d9d
https://hal-amu.archives-ouvertes.fr/hal-02067483
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