Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nele Johanna Hempel"'
Autor:
Nele-Johanna Hempel, Padryk Merkl, Matthias Manne Knopp, Ragna Berthelsen, Alexandra Teleki, Anders Kragh Hansen, Georgios A. Sotiriou, Korbinian Löbmann
Publikováno v:
Molecules, Vol 26, Iss 13, p 4035 (2021)
Laser radiation has been shown to be a promising approach for in situ amorphization, i.e., drug amorphization inside the final dosage form. Upon exposure to laser radiation, elevated temperatures in the compacts are obtained. At temperatures above th
Externí odkaz:
https://doaj.org/article/521318070367416199aea4048ba9fa36
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 886 (2021)
Microwave-induced in situ amorphization of a drug into a polymeric amorphous solid dispersion (ASD) has been suggested to follow a dissolution process of the drug into the polymeric network, at temperatures above the glass transition temperature (Tg)
Externí odkaz:
https://doaj.org/article/f110e847334a4faa8bcfdc6e4a1f185b
Autor:
Nele-Johanna Hempel, Padryk Merkl, Matthias Manne Knopp, Ragna Berthelsen, Alexandra Teleki, Georgios A. Sotiriou, Korbinian Löbmann
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 917 (2021)
In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug–polymer combinations were studied with regard to the infl
Externí odkaz:
https://doaj.org/article/44615c36a38d4452ac95afc63d8664d0
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 389 (2021)
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two or more (initially crystalline) low molecular weight components that form a homogeneous single-phase amorphous system. Over the past decades, CAMS have been widely
Externí odkaz:
https://doaj.org/article/a4bf68ebfd7b49c4b1cfb0faabf0e9f6
Publikováno v:
Molecules, Vol 26, Iss 1, p 110 (2020)
Microwaved-induced in situ amorphization of a drug in a polymer has been suggested to follow a dissolution process, with the drug dissolving into the mobile polymer at temperatures above the glass transition temperature (Tg) of the polymer. Thus, bas
Externí odkaz:
https://doaj.org/article/bc650dede1834664ab08830ff86e0aaa
Publikováno v:
Molecules, Vol 25, Iss 5, p 1068 (2020)
The aim of the study was to investigate the suitability of a convection oven to induce in situ amorphization. The study was conducted using microwave radiation-induced in situ amorphization as reference, as it has recently been shown to enable the pr
Externí odkaz:
https://doaj.org/article/e3a5349923ed4cdb9a8531ccd267154f
Autor:
Korbinian Löbmann, Christel A. S. Bergström, Nele-Johanna Hempel, Padryk Merkl, Shno Asad, Ragna Berthelsen, Georgios A. Sotiriou, Alexandra Teleki, Matthias Manne Knopp
Publikováno v:
Molecular Pharmaceutics. 18:2254-2262
Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically insta
Autor:
Ragna Berthelsen, Korbinian Löbmann, Nele-Johanna Hempel, Matthias Manne Knopp, Flemming Morsch
Publikováno v:
Journal of Pharmaceutical Sciences. 110:155-163
Microwave-induced in situ amorphization is a promising approach to circumvent stability and manufacturing issues associated with amorphous solid dispersions (ASD). Using in situ amorphization, the crystalline state of the drug is converted into its a
Autor:
J. Axel Zeitler, Nele-Johanna Hempel, Matthias Manne Knopp, Korbinian Löbmann, Ragna Berthelsen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 149:77-84
In this study, the impact of drug and polymer particle size on the in situ amorphization using microwave irradiation at a frequency of 2.45 GHz were investigated. Using ball milling and sieve fractioning, the crystalline drug celecoxib (CCX) and the
Publikováno v:
Pharmaceutics
Volume 13
Issue 6
Pharmaceutics, Vol 13, Iss 886, p 886 (2021)
Hempel, N J, Knopp, M M, Löbmann, K & Berthelsen, R 2021, ' Studying the impact of the temperature and sorbed water during microwave-induced In Situ amorphization : A case study of celecoxib and polyvinylpyrrolidone ', Pharmaceutics, vol. 13, no. 6, 886 . https://doi.org/10.3390/pharmaceutics13060886
Volume 13
Issue 6
Pharmaceutics, Vol 13, Iss 886, p 886 (2021)
Hempel, N J, Knopp, M M, Löbmann, K & Berthelsen, R 2021, ' Studying the impact of the temperature and sorbed water during microwave-induced In Situ amorphization : A case study of celecoxib and polyvinylpyrrolidone ', Pharmaceutics, vol. 13, no. 6, 886 . https://doi.org/10.3390/pharmaceutics13060886
Microwave-induced in situ amorphization of a drug into a polymeric amorphous solid dispersion (ASD) has been suggested to follow a dissolution process of the drug into the polymeric network, at temperatures above the glass transition temperature (Tg)