Výsledky vyhledávání

Akademický článek

Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model.

Autor: Christian S Bruells, Karen Maes, Rolf Rossaint, Debby Thomas, Nele Cielen, Christian Bleilevens, Ingmar Bergs, Ursina Loetscher, Agnes Dreier, Ghislaine Gayan-Ramirez, Brad J Behnke, Joachim Weis

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e70524 (2013)

OBJECTIVE: Mechanical ventilation (MV) is a life saving intervention for patients with respiratory failure. Even after 6 hours of MV, diaphragm atrophy and dysfunction (collectively referred to as ventilator-induced diaphragmatic dysfunction, VIDD) o

Externí odkaz: https://doaj.org/article/19dd0e673168450492dca31c0ea61e8c

Zobrazit plný text záznamu

Novel cryoballoon to isolate pulmonary veins in patients with paroxysmal atrial fibrillation: long-term outcomes in a multicentre clinical study

Autor: Andrew Martin, Marina Fowler, Toni Breskovic, Alexandre Ouss, Lukas Dekker, Sing-Chien Yap, Rohit Bhagwandien, Elizabeth M. Albrecht, Nele Cielen, Elizabeth Richards, Binh C. Tran, Nigel Lever, Ante Anic

Publikováno v: Journal of Interventional Cardiac Electrophysiology, 65(3), 609-616. Springer Netherlands

Background Recently, a novel cryoballoon ablation catheter has demonstrated acute safety and efficacy in de novo pulmonary vein isolation (PVI) procedures in patients with paroxysmal atrial fibrillation (PAF). However, there are limited studies demon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f690653edd4748217e839dd059b9d733
https://www.bib.irb.hr/1247685

Zobrazit plný text záznamu

The effects of smoking on whisker movements: A quantitative measure of exploratory behaviour in rodents

Autor: Gina L. J. Galli, Wim Janssens, Hans Degens, Nele Cielen, Karen Maes, Robyn A. Grant, Ghislaine Gayan-Ramirez, Nele Heulens

Publikováno v: Behavioural Processes. 128:17-23

Nicotine, an important component of cigarette smoke, is a neurotransmitter that contributes to stress, depression and anxiety in smokers. In rodents, it increases anxiety and reduces exploratory behaviours. However, so far, the measurements of explor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b366aa3c8d8dce1b7020b39c768474
https://doi.org/10.1016/j.beproc.2016.03.021

Zobrazit plný text záznamu

Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model

Autor: Chantal Mathieu, Geert Carmeliet, Nele Heulens, Nele Cielen, Ghislaine Gayan-Ramirez, Karen Maes, Wim Janssens

Publikováno v: The Journal of Endocrinology

Chronic obstructive pulmonary disease (COPD) is associated with skeletal muscle dysfunction. Vitamin D plays an important role in muscle strength and performance in healthy individuals. In COPD, vitamin D deficiency is highly prevalent but its role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95e0fa4f3c4e02a4d9c607ea161e4f7
https://doi.org/10.1530/joe-15-0491

Zobrazit plný text záznamu

Effects of Controlled Mechanical Ventilation on Sepsis-Induced Diaphragm Dysfunction in Rats

Autor: K Maes, Debby Thomas, Sabah N. A. Hussain, Marc Decramer, Nele Cielen, Angela Stamiris, Ashley J. Smuder, Scott K. Powers, Ghislaine Gayan-Ramirez, Greet Hermans, Felipe de Souza Leite

Publikováno v: Critical Care Medicine. 42:e772-e782

Diaphragm dysfunction develops during severe sepsis as a consequence of hemodynamic, metabolic, and intrinsic abnormalities. Similarly, 12 hours of controlled mechanical ventilation also promotes diaphragm dysfunction. Importantly, patients with seps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683181f083cd6179bb4e75ae09c53cab
https://doi.org/10.1097/ccm.0000000000000685

Zobrazit plný text záznamu

A satellite cell‐specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle

Autor: Mieke Sinnesael, Louise Deldicque, Dirk Vanderschueren, Nele Cielen, Christine Helsen, Liesbeth Clinckemalie, Peter Hespel, Ghislaine Gayan-Ramirez, Geert Carmeliet, Frank Claessens, Michaël R. Laurent, Lien Spans, Vanessa Dubois

Publikováno v: The FASEB Journal. 28:2979-2994

Androgens have well-established anabolic actions on skeletal muscle, although the direct effects of the androgen receptor (AR) in muscle remain unclear. We generated satellite cell-specific AR-knockout (satARKO) mice in which the AR is selectively ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bcd8a7662a1a9bbf7adb27573e7a68
https://doi.org/10.1096/fj.14-249748

Zobrazit plný text záznamu

Sedation Using Propofol Induces Similar Diaphragm Dysfunction and Atrophy during Spontaneous Breathing and Mechanical Ventilation in Rats

Autor: Joachim Weis, Nele Cielen, Karen Maes, Rolf Rossaint, Debby Thomas, Christian Bleilevens, Ingmar Bergs, Christian S. Bruells, Ghislaine Gayan-Ramirez

Publikováno v: Anesthesiology. 120:665-672

Background: Mechanical ventilation is crucial for patients with respiratory failure. The mechanical takeover of diaphragm function leads to diaphragm dysfunction and atrophy (ventilator-induced diaphragmatic dysfunction), with an increase in oxidativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca96e2c679507b19a773e6146e9fa01f
https://doi.org/10.1097/aln.0000000000000125

Zobrazit plný text záznamu

Interaction between Physical Activity and Smoking on Lung, Muscle, and Bone in Mice

Autor: Thierry Troosters, Nele Heulens, Ghislaine N. Gayan-Ramirez, Nele Cielen, Geert Carmeliet, Wim Janssens, Karen Maes

Publikováno v: American journal of respiratory cell and molecular biology. 54(5)

Physical inactivity is an important contributor to skeletal muscle weakness, osteoporosis and weight loss in chronic obstructive pulmonary disease. However, the effects of physical inactivity, in interaction with smoking, on lung, muscle and bone are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a2eb8d19b84b2a25a96687d45452af
https://pubmed.ncbi.nlm.nih.gov/26448063

Zobrazit plný text záznamu

Vitamin D deficiency exacerbates COPD-like characteristics in the lungs of cigarette smoke-exposed mice

Autor: Nele Heulens, Conny Gysemans, Chantal Mathieu, Karen Maes, Hannelie Korf, Erik Verbeken, Wim Janssens, Elien De Smidt, Ghislaine Gayan-Ramirez, Nele Cielen

Publikováno v: Respiratory Research

Background Chronic obstructive pulmonary disease (COPD) is characterized by excessive inflammation and disturbed bacterial clearance in the airways. Although cigarette smoke (CS) exposure poses a major risk, vitamin D deficiency could potentially con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae5e52dbd7da21d28381e8c6263cabf
http://europepmc.org/articles/PMC4574263

Zobrazit plný text záznamu

Musculoskeletal Disorders in Chronic Obstructive Pulmonary Disease

Autor: Karen Maes, Nele Cielen, Ghislaine Gayan-Ramirez

Publikováno v: BioMed Research International, Vol 2014 (2014)
BioMed Research International

Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by airway obstruction and inflammation but also accompanied by several extrapulmonary consequences, such as skeletal muscle weakness and osteoporosis. Skeletal muscle weakne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ce688d2a939471baf949d13801acfd
https://doaj.org/article/d6d027b33b2e4833b9242282262205f3

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání