Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nele Plock"'
Autor:
Bhargava Kandala, Nele Plock, Akshita Chawla, Anna Largajolli, Seth Robey, Kenny Watson, Raj Thatavarti, Sheri A. Dubey, S.Y. Amy Cheung, Rik de Greef, Julie Stone, Jeffrey R. Sachs
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104264- (2022)
Summary: Background: The COVID-19 pandemic has increased the need for innovative quantitative decision tools to support rapid development of safe and efficacious vaccines against SARS-CoV-2. To meet that need, we developed and applied a model-based m
Externí odkaz:
https://doaj.org/article/de1aa37726f44b35900d070763f50f39
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1092-1106 (2021)
Abstract Pharmacometric models can enhance clinical decision making, with covariates exposing potential contributions to variability of subpopulation characteristics, for example, demographics or disease status. Intuitive visualization of models with
Externí odkaz:
https://doaj.org/article/c21fd9582c8f4d6bb77d5556f2d45d1d
Autor:
Brian M. Maas, Jos Lommerse, Nele Plock, Radha A. Railkar, S.Y. Amy Cheung, Luzelena Caro, Jingxian Chen, Wen Liu, Ying Zhang, Qinlei Huang, Wei Gao, Li Qin, Jie Meng, Han Witjes, Emilie Schindler, Benjamin Guiastrennec, Francesco Bellanti, Daniel S. Spellman, Brad Roadcap, Mariya Kalinova, Juin Fok-Seang, Andrew P. Catchpole, Amy S. Espeseth, S. Aubrey Stoch, Eseng Lai, Kalpit A. Vora, Antonios O. Aliprantis, Jeffrey R. Sachs
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103651- (2021)
Background: Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants. Development and validat
Externí odkaz:
https://doaj.org/article/29110f874edd46dea00e331b42ac8484
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Pharmacometric models can enhance clinical decision making, with covariates exposing potential contributions to variability of subpopulation characteristics, for example, demographics or disease status. Intuitive visualization of models with multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e381a9e21bdc106caee5a83829646a9
https://pubmed.ncbi.nlm.nih.gov/34242494
https://pubmed.ncbi.nlm.nih.gov/34242494
Autor:
Anna Largajolli, Nele Plock, Bhargava Kandala, Akshita Chawla, Seth H Robey, Kenny Watson, Raj Thatavarti, Sheri Dubey, S Y Amy Cheung, Rik de Greef, Jeffrey R Sachs
Publikováno v:
Open Forum Infectious Diseases
Background Several COVID-19 vaccines have been authorized, and the need for rapid, further modification is anticipated. This work uses a Model-Based Meta-Analysis (MBMA) to relate, across species, immunogenicity to peak viral load (VL) after challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42956c137219474f5e9e4c0d07e525f9
http://europepmc.org/articles/PMC8690825
http://europepmc.org/articles/PMC8690825
Autor:
Nele Plock, Jos Lommerse, Brian M Maas, Jingxian Chen, Francesco Bellanti, Li Qin, Han Witjes, Philippe Pierrillas, Radha Railkar, Antonios O Aliprantis, Kalpit A Vora, Wei Gao, Luzelena Caro, S Y Amy Cheung, Jeffrey R Sachs
Publikováno v:
Open Forum Infectious Diseases. 8:S597-S598
Background MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody under development to prevent RSV infection in infants. A model-based meta-analysis (MBMA) describing the relationship between RSV serum neutrali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a506a56ab48c3064544351f5d09d28
https://doi.org/10.1093/ofid/ofab466.1207
https://doi.org/10.1093/ofid/ofab466.1207
Autor:
Francesco Bellanti, Antonios O. Aliprantis, Juin Fok-Seang, Wen Liu, Jeffrey R. Sachs, Radha Railkar, Brad Roadcap, Kalpit A. Vora, Qinlei Huang, Li Qin, Nele Plock, W. Gao, Eseng Lai, Daniel S. Spellman, Jingxian Chen, Andrew P. Catchpole, Emilie Schindler, Mariya Kalinova, Amy S. Espeseth, Jie Meng, S. Y. Amy Cheung, Luzelena Caro, S. Aubrey Stoch, Benjamin Guiastrennec, Jos Lommerse, Brian M. Maas, Ying Zhang, Han Witjes
Publikováno v:
EBioMedicine, Vol 73, Iss, Pp 103651-(2021)
EBioMedicine
EBioMedicine
Background Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants. Development and validati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979efaad60d5195380f7df59609ee178
https://doi.org/10.1016/j.ebiom.2021.103651
https://doi.org/10.1016/j.ebiom.2021.103651
Autor:
Meindert Danhof, Katia M.C. Verhamme, Willem de Winter, Steve Choy, Janna K. Duong, Himanshu Naik, Miriam C. J. M. Sturkenboom, Bruno H. Stricker, Walter Krauwinkel, Nele Plock, Sandra A.G. Visser
Publikováno v:
British Journal of Clinical Pharmacology. 83:487-497
Aim: The weight-glycosylated haemoglobin (HbA1C)-insulin-glucose (WHIG) model describes the effects of changes in weight on insulin sensitivity (IS) in newly diagnosed, obese subjects receiving placebo treatment. This model was applied to a wider pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7928545671c38c30ff3776f9f054df97
https://doi.org/10.1111/bcp.13144
https://doi.org/10.1111/bcp.13144
Publikováno v:
The Journal of Clinical Pharmacology. 57:52-63
The presented analysis was performed to characterize the relationship between treatment-related early (week 4) and longer term (3-6 months) weight loss to understand the potential utility of 4-week proof-of-mechanism studies in the early decision-mak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76df3e6135f84b9c90761e9d25c7c32a
https://doi.org/10.1002/jcph.781
https://doi.org/10.1002/jcph.781
Publikováno v:
Pharmacology Research & Perspectives
We are studying the fully human, IgG1λ cytolytic monoclonal antibody TAK‐079, which binds CD38. CD38 is expressed on plasma and natural killer (NK) cells constitutively and upregulated on subsets of B and T lymphocytes upon activation. TAK‐079 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b87b3ad2a54fd8e210e67af682747e
http://europepmc.org/articles/PMC5980133
http://europepmc.org/articles/PMC5980133