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Akademický článek

Warehouse-based, immunopeptidome-guided design of personalised peptide vaccines shows feasibility in clinical trial evaluation in CLL patients

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Cancer peptide vaccination represents a promising therapeutic approach, but has been hampered by lack of suitable antigens and restricted applicability due to different HLA backgrounds of individual patients. We here introduce a novel warehouse-based

Externí odkaz: https://doaj.org/article/4e1b48fe04f94a3ea04c70520a8bf38c

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Akademický článek

AML-VAC-XS15-01: protocol of a first-in-human clinical trial to evaluate the safety, tolerability and preliminary efficacy of a multi-peptide vaccine based on leukemia stem cell antigens in acute myeloid leukemia patients

Autor: Susanne Jung, Annika Nelde, Yacine Maringer, Monika Denk, Lisa Zieschang, Christine Kammer, Melek Özbek, Peter Martus, Christopher Hackenbruch, Alexander Englisch, Jonas S. Heitmann, Helmut R. Salih, Juliane S. Walz

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionAcute myeloid leukemia (AML) has a dismal prognosis, mostly due to minimal residual disease-driven relapse, making an elimination of persisting therapy-resistant leukemia progenitor/stem cells (LPCs) the main goal for novel therapies. Pep

Externí odkaz: https://doaj.org/article/4ad85c4b3c4a4a858a9ec662b89e13e5

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Akademický článek

Association Between Stroke Lesion Size and Atrial Fibrillation Detected After Stroke: An Observational Cohort Study

Autor: Markus G. Klammer, Laura Reimann, Oskar Richter, Simone Lieschke, Helena Stengl, Simon Hellwig, Ramanan Ganeshan, Maximilian Schöls, Alexander Nelde, Christian Meisel, Kersten Villringer, Christian H. Nolte, Matthias Endres, Jan Friedrich Scheitz

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 19 (2024)

Background Atrial fibrillation detected after stroke (AFDAS) is considered to be a distinct entity influenced by cardiogenic and neurogenic factors. We hypothesized that patients with AFDAS have larger stroke lesions than patients without atrial fibr

Externí odkaz: https://doaj.org/article/7e1e2a50f38d4ed9a5dcb40960f7a5c2

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Akademický článek

iVAC-XS15-CLL01: personalized multi-peptide vaccination in combination with the TLR1/2 ligand XS15 in CLL patients undergoing BTK-inhibitor-based regimens

Autor: Alexander Englisch, Clara Hayn, Susanne Jung, Jonas S. Heitmann, Christopher Hackenbruch, Yacine Maringer, Annika Nelde, Marcel Wacker, Monika Denk, Lisa Zieschang, Christine Kammer, Peter Martus, Helmut R. Salih, Juliane S. Walz

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

Chronic lymphocytic leukemia (CLL) is the most common form of leukemia among adults in Western countries. Despite the introduction of targeted therapies, including first-line Bruton’s tyrosine kinase inhibitor (BTKi) treatment, CLL remains largely

Externí odkaz: https://doaj.org/article/dd7432dd452f4e3c895e7e3e1fbf5b55

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Quantification of systematic errors in the electron density and temperature measured with Thomson scattering at W7-X

Autor: Nelde, Philipp, Fuchert, Golo, Pasch, Ekkehard, Beurskens, Marc N. A., Bozhenkov, Sergey A., Brunner, Kai Jakob, Höfel, Udo, Kwak, Sehyun, Meineke, Jens, Scott, Evan R., Wolf, Robert C., team, W7-X

The electron density and temperature profiles measured with Thomson scattering at the stellarator Wendelstein 7-X show features which seem to be unphysical, but so far could not be associated with any source of error considered in the data processing

Externí odkaz: http://arxiv.org/abs/2111.03562

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Akademický článek

TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract T cell recognition of human leukocyte antigen (HLA)-presented tumor-associated peptides is central for cancer immune surveillance. Mass spectrometry (MS)-based immunopeptidomics represents the only unbiased method for the direct identificati

Externí odkaz: https://doaj.org/article/dbea2b72e80845b88f66d5852cf7b946

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Feedback induced locking in semiconductor lasers with strong amplitude-phase coupling

Autor: Hausen, Jan, Herzog, Bastian, Nelde, Alexander, Meinecke, Stefan, Owschimikow, Nina, Lüdge, Kathy

Publikováno v: Phys. Rev. A 103, 043511 (2021)

The influence of optical feedback on semiconductor lasers has been a widely studied field of research due to fundamental interests as well as the optimization of optical data transmission and computing. Recent publications have shown that it is possi

Externí odkaz: http://arxiv.org/abs/2101.01623

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Akademický článek

FusionVAC22_01: a phase I clinical trial evaluating a DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocellular carcinoma and other tumor entities carrying the oncogenic driver fusion

Autor: Christopher Hackenbruch, Jens Bauer, Jonas S. Heitmann, Yacine Maringer, Annika Nelde, Monika Denk, Lisa Zieschang, Christine Kammer, Birgit Federmann, Susanne Jung, Peter Martus, Nisar P. Malek, Konstantin Nikolaou, Helmut R. Salih, Michael Bitzer, Juliane S. Walz

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

The DNAJB1-PRKACA fusion transcript was identified as the oncogenic driver of tumor pathogenesis in fibrolamellar hepatocellular carcinoma (FL-HCC), also known as fibrolamellar carcinoma (FLC), as well as in other tumor entities, thus representing a

Externí odkaz: https://doaj.org/article/a2dd1647213e47a0b299877dea3ea6f4

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Akademický článek

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