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Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis.

Autor: Sonigra A; Department of Rheumatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia., Nel HJ; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia., Wehr P; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia., Ramnoruth N; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia., Patel S; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia., van Schie KA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands., Bladen MW; Melbourne Integrative Genomics and School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia., Mehdi AM; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia., Tesiram J; Department of Rheumatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia., Talekar M; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia., Rossjohn J; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Reid HH; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Stuurman FE; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia., Roberts H; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia.; Dendright Pty Ltd, Brisbane, Queensland, Australia., Vecchio P; Department of Rheumatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia., Gourley I; Immunology Clinical Development, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Rigby M; Immunology Clinical Development, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Becart S; Discovery Immunology, Janssen Research & Development, LLC, La Jolla, California, USA., Toes RE; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands., Scherer HU; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands., Lê Cao KA; Melbourne Integrative Genomics and School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia., Campbell K; Immunology Translational Medicine, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Thomas R; University of Queensland Diamantina Institute, the University of Queensland, Woolloongabba, Queensland, Australia.

Publikováno v: JCI insight [JCI Insight] 2022 Oct 24; Vol. 7 (20). Date of Electronic Publication: 2022 Oct 24.

IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes.

Autor: Greenbaum CJ; Center for Interventional Immunology and Diabetes Program, Benaroya Research Institute, Seattle, Washington, USA., Serti E; Immune Tolerance Network, Seattle, Washington, USA., Lambert K; Center for Interventional Immunology and Diabetes Program, Benaroya Research Institute, Seattle, Washington, USA., Weiner LJ; Rho, Inc, Durham, North Carolina, USA., Kanaparthi S; Immune Tolerance Network, Seattle, Washington, USA., Lord S; Center for Interventional Immunology and Diabetes Program, Benaroya Research Institute, Seattle, Washington, USA., Gitelman SE; University of California, San Francisco, San Francisco, California, USA., Wilson DM; Stanford University, Stanford, California, USA., Gaglia JL; Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA., Griffin KJ; Sanford Health, San Jose, California, USA., Russell WE; Vanderbilt University, Nashville, Tennessee, USA., Raskin P; University of Texas, Southwestern, Dallas, Texas, USA., Moran A; University of Minnesota, Minneapolis, Minnesota, USA., Willi SM; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Tsalikian E; University of Iowa, Iowa City, Iowa, USA., DiMeglio LA; Riley Children's Hospital, Indiana University, Indianapolis, Indiana, USA., Herold KC; Yale University, New Haven Connecticut, USA., Moore WV; University of Missouri, Kansas City, Kansas City, Missouri, USA., Goland R; Columbia University, New York, New York, USA., Harris M; Children's Health Queensland Hospital, South Brisbane, Australia.; University of Queensland, Queensland, Brisbane, Australia., Craig ME; University of Sydney, Sydney New South Wales, Australia., Schatz DA; University of Florida, Gainesville, Florida, USA., Baidal DA; University of Miami, Coral Gables, Florida, USA., Rodriguez H; University of South Florida, Tampa, Florida, USA., Utzschneider KM; VA Puget Sound and the University of Washington, Seattle, Washington, USA., Nel HJ; University of Queensland, Queensland, Brisbane, Australia., Soppe CL; Immune Tolerance Network, Seattle, Washington, USA., Boyle KD; Rho, Inc, Durham, North Carolina, USA., Cerosaletti K; Center for Interventional Immunology and Diabetes Program, Benaroya Research Institute, Seattle, Washington, USA., Keyes-Elstein L; Rho, Inc, Durham, North Carolina, USA., Long SA; Center for Interventional Immunology and Diabetes Program, Benaroya Research Institute, Seattle, Washington, USA., Thomas R; University of Queensland, Queensland, Brisbane, Australia., McNamara JG; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA., Buckner JH; Center for Interventional Immunology and Diabetes Program, Benaroya Research Institute, Seattle, Washington, USA., Sanda S; Immune Tolerance Network, Seattle, Washington, USA.; University of California, San Francisco, San Francisco, California, USA.

Publikováno v: JCI insight [JCI Insight] 2021 Nov 08; Vol. 6 (21). Date of Electronic Publication: 2021 Nov 08.

Optimization of a Method to Detect Autoantigen-Specific T-Cell Responses in Type 1 Diabetes.

Autor: Musthaffa Y; Department of Endocrinology and Diabetes, Queensland Children's Hospital, South Brisbane, QLD, Australia.; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Nel HJ; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Ramnoruth N; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Patel S; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Hamilton-Williams EE; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Harris M; Department of Endocrinology and Diabetes, Queensland Children's Hospital, South Brisbane, QLD, Australia.; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Thomas R; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Dec 07; Vol. 11, pp. 587469. Date of Electronic Publication: 2020 Dec 07 (Print Publication: 2020).

Altered Repertoire Diversity and Disease-Associated Clonal Expansions Revealed by T Cell Receptor Immunosequencing in Ankylosing Spondylitis Patients.

Autor: Hanson AL; University of Queensland, Brisbane, Queensland, Australia., Nel HJ; University of Queensland, Brisbane, Queensland, Australia., Bradbury L; Queensland University of Technology and Translational Research Institute, Brisbane, Queensland, Australia., Phipps J; Queensland University of Technology and Translational Research Institute, Brisbane, Queensland, Australia., Thomas R; University of Queensland, Brisbane, Queensland, Australia., Lê Cao KA; University of Melbourne, Melbourne, Victoria, Australia., Kenna TJ; Queensland University of Technology and Translational Research Institute, Brisbane, Queensland, Australia., Brown MA; Queensland University of Technology and Translational Research Institute, Brisbane, Queensland, Australia, and Guy's and St Thomas' NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, UK.

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2020 Aug; Vol. 72 (8), pp. 1289-1302. Date of Electronic Publication: 2020 Jul 13.