Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Nektarios Tavernarakis"'
Autor:
Nikolaos Charmpilas, Aggeliki Sotiriou, Konstantinos Axarlis, Nektarios Tavernarakis, Thorsten Hoppe
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114336- (2024)
Summary: Proteome integrity is fundamental for cellular and organismal homeostasis. The mitochondrial unfolded protein response (UPRmt), a key component of the proteostasis network, is activated in a non-cell-autonomous manner in response to mitochon
Externí odkaz:
https://doaj.org/article/bac15514762549e78fb75f4b85a97b52
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102801- (2024)
Summary: C. elegans is a bacteria-eating soil-dwelling nematode. Typical cultivation of laboratory-reared populations occurs on bacteria-covered solid media, where they move along with sinusoidal undulations. Nematodes decelerate when they encounter
Externí odkaz:
https://doaj.org/article/2733e00ef7e84c5e863e855c85194f1d
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-15 (2023)
Abstract Mitochondria preserve metabolic homeostasis and integrate stress signals, to trigger cytoprotective, or cell death pathways. Mitochondrial homeostasis and function decline with age. The mechanisms underlying the deterioration of mitochondria
Externí odkaz:
https://doaj.org/article/065712b45c904623bd1fd16c3391ca7f
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107117- (2023)
Summary: The nervous system participates in the initiation and modulation of systemic stress. Ionstasis is of utmost importance for neuronal function. Imbalance in neuronal sodium homeostasis is associated with pathologies of the nervous system. Howe
Externí odkaz:
https://doaj.org/article/0c628063972349fbb41efd139f864a90
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/bb5ac9570cc44762bd0273bea2f08857
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102250- (2023)
Summary: Here, we present an olfactory-dependent chemotaxis assay for evaluating changes in memory-like behavior in both wild-type and Alzheimer’s-disease-like C. elegans models. We describe steps for synchronizing and preparing C. elegans populati
Externí odkaz:
https://doaj.org/article/737020570c124c2da7a3bd3537c65f9c
Autor:
Ádám Sturm, Himani Sharma, Ferenc Bodnár, Maryam Aslam, Tibor Kovács, Ákos Németh, Bernadette Hotzi, Viktor Billes, Tímea Sigmond, Kitti Tátrai, Balázs Egyed, Blanka Téglás-Huszár, Gitta Schlosser, Nikolaos Charmpilas, Christina Ploumi, András Perczel, Nektarios Tavernarakis, Tibor Vellai
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14858 (2023)
N6-methyladenine (6mA) in the DNA is a conserved epigenetic mark with various cellular, physiological and developmental functions. Although the presence of 6mA was discovered a few years ago in the nuclear genome of distantly related animal taxa and
Externí odkaz:
https://doaj.org/article/cd5d484ad5f849f6b93ef5ece03f3d91
Autor:
Eirini Lionaki, Ilias Gkikas, Ioanna Daskalaki, Maria-Konstantina Ioannidi, Maria I. Klapa, Nektarios Tavernarakis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mitochondrial function is linked to lifespan. Here the authors show that inhibition of mitochondrial protein import leads to a reduction in mitochondrial abundance and extends lifespan in Caenorhabditis elegans via activation of glycolysis and de nov
Externí odkaz:
https://doaj.org/article/6d8502fffa9c4eec8207e9c7490b27c1
Publikováno v:
Cells, Vol 12, Iss 16, p 2024 (2023)
The mTORC1 nutrient-sensing pathway integrates metabolic and endocrine signals into the brain to evoke physiological responses to food deprivation, such as autophagy. Nevertheless, the impact of neuronal mTORC1 activity on neuronal circuits and organ
Externí odkaz:
https://doaj.org/article/69b06cef307244969461178ba94409bf
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101264- (2022)
Summary: Transgenic Caenorhabditis elegans that expresses the full-length wild-type human α-synuclein in dopaminergic neurons provides a well-established Parkinson’s disease (PD) nematode model. Here, we present a detailed protocol to monitor and
Externí odkaz:
https://doaj.org/article/c5ae3ab080fd4347a5dbcb8dc957a4b4