Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nekoye Otsyula"'
Autor:
Vito Baraka, Abel Nhama, Pedro Aide, Quique Bassat, Agatha David, Samwel Gesase, Jonathan Gwasupika, Sebastian Hachizovu, Geofrey Makenga, Christian Ruchaho Ntizimira, Orikomaba Obunge, Kitoto Antoinette Tshefu, Marc Cousin, Nekoye Otsyula, Rashidkhan Pathan, Céline Risterucci, Guoqin Su, Christine Manyando
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background This study aimed to evaluate the gap between guidelines and local clinical practice for diagnosis and treatment of uncomplicated and severe malaria, the patient characteristics, diagnostic approach, treatment, and compliance to st
Externí odkaz:
https://doaj.org/article/f8c57da348e04d94811c5f69c0a69b8b
Autor:
Ismail Mahat Bashir, Nekoye Otsyula, George Awinda, Michele Spring, Petra Schneider, John Njenga Waitumbi
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e56828 (2013)
Compared to expert malaria microscopy, malaria biomarkers such as Plasmodium falciparum histidine rich protein-2 (PfHRP-2), and PCR provide superior analytical sensitivity and specificity for quantifying malaria parasites infections. This study repor
Externí odkaz:
https://doaj.org/article/efcf76ded6b04dd099e4a1fb3390d1fc
Autor:
Nekoye Otsyula, Mary J. Hamel, Didier Leboulleux, Effua Abigail Usuf, Maria Oziemkowska, Joseph Abuodha, Kephas Otieno, Jessica Cowden, Emmanuel Owino, Martina Oneko, Yolanda Guerra Mendoza, Norbert Awino, Dirk Heerwegh, Karen Ivinson, Lucas Otieno, Janet Oyieko, Ben Andagalu, Allan Otieno, Johan Vekemans, Walter Otieno, Amanda J. Leach, Chris Odero, Simon Kariuki, Didier Lapierre, Bernhards Ogutu, Laurence Slutsker, Marc Lievens
Publikováno v:
The Lancet Infectious Diseases. 16:1134-1144
Malaria remains a major global public health concern, especially in sub-Saharan Africa. The RTS,S/AS01 malaria candidate vaccine was reviewed by the European Medicines Agency and received a positive scientific opinion; WHO subsequently recommended pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595fc80a814c12b9be5bf61eb437152d
https://doi.org/10.1016/s1473-3099(16)30161-x
https://doi.org/10.1016/s1473-3099(16)30161-x
Autor:
Chantal Din-Bell, Jana Held, Ali Sié, Carmen L. Ospina Salazar, Sodiomon B. Sirima, Alain Nahum, Léa Nadège Bonkian, Nekoye Otsyula, Lucas Otieno, Ahmed M Abdallah, Peter G. Kremsner, Bertrand Lell, Bancole Moulero, Robert Kimutai, Kimiko Koiwai, Mohamadou Siribié, Elhadj Djeriou, Cathy Cantalloube, Benjamin Mordmüller, Maryvonne Kombila, Marielle K. Bouyou-Akotet, Christian Supan, Daniel Ter-Minassian, Halidou Tinto, John N. Waitumbi, Boubacar Coulibaly
Publikováno v:
The Lancet Infectious Diseases. 15:1409-1419
Summary Background Artemisinin-based combination therapies (ACTs) are the recommended first-line treatment for uncomplicated Plasmodium falciparum malaria. Ferroquine is a new combination partner for fast-acting ACTs such as artesunate. We aimed to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f0670e21fe687311ae1c2979ef20bc
https://doi.org/10.1016/s1473-3099(15)00079-1
https://doi.org/10.1016/s1473-3099(15)00079-1
Autor:
Seth Owusu-Agyei, Jahit Sacarlal, Kalifa Bojang, Emmanuel Mahama, John Lusingu, Michael T. White, Nekoye Otsyula, Nahya Salim, Ally Olotu, John J. Aponte, Selidji T Agnandji, Kwaku Poku Asante, Jamie T. Griffin, Tsiri Agbenyega, Philip Bejon, Salim Abdulla, Azra C. Ghani, Bertrand Lell, Daniel Ansong
Publikováno v:
BMC Medicine
Background: The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and episodes of clinical malaria. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde7d8763aad93281d9e5fdcdb6c89d4
https://doi.org/10.1186/s12916-014-0117-2
https://doi.org/10.1186/s12916-014-0117-2
Autor:
Nahya Salim, Nekoye Otsyula, Kalifa Bojang, Selidji T Agnandji, Seth Owusu-Agyei, Ally Olotu, John Lusingu, Salim Abdulla, Philip Bejon, Azra C. Ghani, Michael T. White, Kwaku Poku Asante
Background: The efficacy of RTS,S/AS01 as a vaccine for malaria is being tested in a phase 3 clinical trial. Early results show significant, albeit partial, protection against clinical malaria and severe malaria. To ascertain variations in vaccine ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beef9f3d9aebdb930706f362394c814
https://doi.org/10.1016/s1473-3099(13)70005-7
https://doi.org/10.1016/s1473-3099(13)70005-7
Autor:
Nekoye Otsyula, Allan Otieno, Peter Sifuna, Jessica Cowden, Walter Otieno, Mary Oyugi, Ben Andagalu, Janet Oyieko, Victorine Owira, Bernhards Ogutu, Lucas Otieno
The Kombewa Health and Demographic Surveillance System (HDSS) grew out of the Kombewa Clinical Research Centre in 2007 and has since established itself as a platform for the conduct of regulated clinical trials, nested studies and local disease surve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9dae078bb99abb539155c8a6b516c5
https://europepmc.org/articles/PMC4258789/
https://europepmc.org/articles/PMC4258789/
Autor:
Ben Andagalu, Meng Shi, Nekoye Otsyula, Margaret Koech, Olivier Godeaux, Evelina Angov, Carter L. Diggs, Brent House, Lisa A. Ware, Donna Tosh, Marie-Claude Dubois, Walter Otieno, W. Ripley Ballou, Nancy O. Richie, D. Gray Heppner, Lori Miller, Michele D. Spring, Joe Cohen, James F. Cummings, Lucas Otieno, Bernhards Ogutu, Christian F. Ockenhouse, Lorraine Soisson, Elke S. Bergmann-Leitner, Jason W. Bennett, Mark E. Polhemus, Godfrey Allan Otieno, Farhat Khan, John N. Waitumbi
Publikováno v:
Malaria Journal
Background The development of an asexual blood stage vaccine against Plasmodium falciparum malaria based on the major merozoite surface protein-1 (MSP1) antigen is founded on the protective efficacy observed in preclinical studies and induction of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be5fa5e36f4c814c866da31dc8935e8
https://doi.org/10.1186/1475-2875-12-29
https://doi.org/10.1186/1475-2875-12-29
Autor:
Nekoye Otsyula, George Awinda, Petra Schneider, Michele D. Spring, Ismail Mahat Bashir, John N. Waitumbi
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e56828 (2013)
Bashir, I, Otsyula, N, Awinda, G, Spring, M, Schneider, P & Waitumbi, J 2013, ' Comparison of PfHRP-2/pLDH ELISA, qPCR and microscopy for the detection of Plasmodium events and prediction of sick visits during a malaria vaccine study. ', PLoS ONE, vol. 8, no. 3, e56828, pp. 1-8 . https://doi.org/10.1371/journal.pone.0056828
PLoS ONE
Bashir, I, Otsyula, N, Awinda, G, Spring, M, Schneider, P & Waitumbi, J 2013, ' Comparison of PfHRP-2/pLDH ELISA, qPCR and microscopy for the detection of Plasmodium events and prediction of sick visits during a malaria vaccine study. ', PLoS ONE, vol. 8, no. 3, e56828, pp. 1-8 . https://doi.org/10.1371/journal.pone.0056828
PLoS ONE
Background Compared to expert malaria microscopy, malaria biomarkers such as Plasmodium falciparum histidine rich protein-2 (PfHRP-2), and PCR provide superior analytical sensitivity and specificity for quantifying malaria parasites infections. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97582307ce22b0179cae089516bf82b
http://europepmc.org/articles/PMC3598859?pdf=render
http://europepmc.org/articles/PMC3598859?pdf=render
Autor:
Esther Oguk, Trudie Lang, Harry Owusu Boateng, Laurence Slutsker, Patricia Njuguna, Francis Martinson, Justice Sylverken, Saumu Ahmed, Nahya Salim, Christine Kerubo, Omari Abdul, Pedro Aide, Gerald Tegha, Innocent Valea, Kevin Marsh, Chimwemwe Chawinga, Preeti Vansadia, Ayola A. Adegnika, Ali Hamad, Irving F. Hoffman, Vincent Muturi-Kioi, Evans Kwara, Norbert Awino, Daniel Ansong, Halidou Tinto, Helder Bulo, Seth Owusu-Agyei, Chris Drakeley, Peter G. Kremsner, Stacey M. O. Gondi, Eusebio Macete, Edwin Liheluka, George Odongo, Owusu Boahen, Kwaku Poku Asante, Portia Kamthunzi, Sonia Machevo, Didier Leboulleux, Mary J. Hamel, Selidji T Agnandji, Samwel Gesase, Jane Kilembe, Hermann Sorgho, Lucas Otieno, Kayla F. Laserson, Marc Lievens, Rutendo Nkomo, Robert T. Guiguemdé, Betuel Sigaúque, Biebo Bihoun, Anangisye Malabeja, Jahit Sacarlal, David C. Kaslow, Daniel Chandramohan, David Schellenberg, Olivier Sombié, Bernhards Ogutu, Roma Chilengi, Ali Ali, Maxmillian Mpina, Amanda J. Leach, Thor G. Theander, John Lusingu, Jean-Bosco Ouédraogo, Anita Lumeka Kabwende, Anima Sarfo, David Dosoo, Benjamin Mordmüller, Pedro L. Alonso, Tisungane Mvalo, Ali Mtoro, Charity Maingi, Yolanda Guerra, John Bawa, Alex Agyekum, Mercy Tsidya, Christian Loucq, Simon Kariuki, Meredith McMorrow, Brian Greenwood, Berenger Kaboré, Barbara Gaelle Nfono Ondo Methogo, Didier Lapierre, Joe Cohen, Samuel Adjei, Johan Vekemans, Barbara Savarese, Marla Sillman, Gabriel Mwambingu, David Sambian, Afiya Radford, George Adjei, Philip Bejon, Walter Otieno, Saadou Issifou, Paul Mutani, Umberto D'Alessandro, Chris Odero, Allan Otieno, Béatrice Peggy Abossolo, Tsiri Agbenyega, Marcel Tanner, Ally Olotu, Lincoln Malle, Kingsley Osei-Kwakye, Tapiwa Tembo, Rose Minja, Salim Abdulla, W. Ripley Ballou, Bertrand Lell, Opokua Ofori-Anyinam, Terrell Carter, José Francisco Fernandes, Miguel Lanaspa, Coline Mahende, Theresa Rettig, Aurélie Olivier, Issa Guiraud, Jon Ben Woods, Nekoye Otsyula, Pauline Akoo, Erik Jongert, M.M. Lemnge, Victorine Owira, Kephas Otieno, Sozinho Acácio, John J. Aponte, Martina Oneko, Isaac Asante
BACKGROUND: The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing phase 3 trial. We studied infants 6 to 12 weeks of age recruited for the sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beaf1d9dda3fe0877c22029a20ff4a88