Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Neki Patel"'
Autor:
Marco Gymnopoulos, Oscar Betancourt, Vincent Blot, Ryo Fujita, Diana Galvan, Vincent Lieuw, Sophie Nguyen, Jeanette Snedden, Christine Stewart, Jose Villicana, Jon Wojciak, Eley Wong, Raul Pardo, Neki Patel, Francois D’Hooge, Balakumar Vijayakrishnan, Conor Barry, John A. Hartley, Philip W. Howard, Roland Newman, Julia Coronella
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 54-68 (2020)
cMet is a well‐characterized oncogene that is the target of many drugs including small molecule and biologic pathway inhibitors, and, more recently, antibody–drug conjugates (ADCs). However, the clinical benefit from cMet‐targeted therapy has b
Externí odkaz:
https://doaj.org/article/deb621ff4dba44b3a242c7c4570c902e
Autor:
Philip W. Howard, John A. Hartley, Mary McFarlane, Luke A. Masterson, Kathryn Ball, Conor S. Barry, Lauren Adams, Rhiannon Beard, K. Phin Chooi, Gyoung-Dong Kang, Ian Hutchinson, Jitka Riedl, Kathleen Santos, Balakumar Vijayakrishnan, Shameen Afif-Rider, Neki Patel, Kathryn Pugh, Stephen J. Gregson
Supplementary Data from Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0808e71ffb8fdea67b4acfbd119e387a
https://doi.org/10.1158/1535-7163.22523461.v1
https://doi.org/10.1158/1535-7163.22523461.v1
Autor:
Rakesh Dixit, Nazzareno Dimasi, Phillip W. Howard, Arnaud Tiberghien, Luke Masterson, Cui Chen, Neki Patel, Shannon Breen, Patricia C. Ryan, Molly Reed, Marlon Rebelatto, Kapil Vashisht, Binyam Bezabeh, Jay Harper, Haihong Zhong, Michele Gunsior, Xiang Qing Yu, Shameen Afif-Rider, Bo Zheng, Pauline M. Ryan, Mary Jane Masson Hinrichs
Purpose: To use preclinical models to identify a dosing schedule that improves tolerability of highly potent pyrrolobenzodiazepine dimers (PBDs) antibody drug conjugates (ADCs) without compromising antitumor activity.Experimental Design: A series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bff01a2c0da935c0ea2819fe0a9ef9
https://doi.org/10.1158/1078-0432.c.6526344
https://doi.org/10.1158/1078-0432.c.6526344
Autor:
Rakesh Dixit, Nazzareno Dimasi, Phillip W. Howard, Arnaud Tiberghien, Luke Masterson, Cui Chen, Neki Patel, Shannon Breen, Patricia C. Ryan, Molly Reed, Marlon Rebelatto, Kapil Vashisht, Binyam Bezabeh, Jay Harper, Haihong Zhong, Michele Gunsior, Xiang Qing Yu, Shameen Afif-Rider, Bo Zheng, Pauline M. Ryan, Mary Jane Masson Hinrichs
Supplementary Figure 1. (a,b) Structure of the payloads SG3249 and SG3400; Supplementary Figure 2. PK concentration vs. time profile of R347-SG3400 in monkeys after either a single IV injection of 4.5mg/kg or 3 weekly IV injections of 1.5mg/kg; Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18262bd2056388988e5e07e301278edb
https://doi.org/10.1158/1078-0432.22466538
https://doi.org/10.1158/1078-0432.22466538
Autor:
Marco Gymnopoulos, Tima Thomas, Diana Gasper, Judith Anderton, Ravinder Tammali, Ed Rosfjord, Nick Durham, Chris Ward, Claire Myers, Jixin Wang, Wenyan Zhong, Simon Christ, Lina Meinecke, Katharina Nekolla, Laura Sebastian Monasor, Roger Dodd, Neki Patel, Mark Albertella, Jorge Zeron-Medina, Paula Fraenkel, Puja Sapra
Publikováno v:
Cancer Research. 83:LB025-LB025
Folate receptor alpha (FRα) is a cell surface GPI-anchored protein overexpressed in several solid tumors with highest prevalence in ovarian cancer and lung adenocarcinoma but restricted expression in normal tissues. An antibody drug conjugate (ADC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c657dc620f6c5ef3de670bb26a735c37
https://doi.org/10.1158/1538-7445.am2023-lb025
https://doi.org/10.1158/1538-7445.am2023-lb025
Publikováno v:
Materials Today: Proceedings. 2:3212-3219
In rotational moulding, due to bi-axial nature of mould rotation, there is a dearth of accurate and cost-effective thermal data measurement techniques and equipment. This necessitates reliable prediction of thickness for different temperatures and cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a03e567984bbd841e6a952cd8167967
https://doi.org/10.1016/j.matpr.2015.07.116
https://doi.org/10.1016/j.matpr.2015.07.116