Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Neka A. Simms"'
Autor:
Neka A. Simms, Yuxiang Dong, Haizhen A. Zhong, Wang Wang, Jonathan L. Vennerstrom, Michael G. Brattain, Dima A. Sabbah, Edward L. Ezell
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:7175-7183
This work describes our efforts to optimize the lead PI3Kα inhibitor N-benzyl 4-hydroxy-2-quinolone-3-carboxamide using structure-based design and molecular docking. We identified a series of N-phenyl 4-hydroxy-2-quinolone-3-carboxamides as selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3e82981baab1ffd83a89feb6ef9210
https://doi.org/10.1016/j.bmc.2012.09.059
https://doi.org/10.1016/j.bmc.2012.09.059
Publikováno v:
HPB. 12(7):498-506
BackgroundThe role of transforming growth factor-β (TGF-β) in the development of hepatic metastasis from colon cancer is not clearly elucidated. The aim of this study was to determine the role of TGF-β in the development of such metastasis.Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb7f8f3f94c2b368d07a947018e372c
Autor:
Haizhen A. Zhong, Michael G. Brattain, Neka A. Simms, Jonathan L. Vennerstrom, Dima A. Sabbah
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
The alpha isoform of the phosphatidylinositol-3-kinases (PI3Kα) is often mutated, amplified and overex-pressed in human tumors. In an effort to develop new inhibitors targeting this enzyme, we carried out a pharmacophore model study based on six PI3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d34b0c93e7fc82519e7eab3c50e019
https://pubmed.ncbi.nlm.nih.gov/22212721
https://pubmed.ncbi.nlm.nih.gov/22212721
Publikováno v:
HPB. 13:593
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc6eb3ec846e43c1978f4833510ad2c
https://doi.org/10.1111/j.1477-2574.2011.00367.x
https://doi.org/10.1111/j.1477-2574.2011.00367.x