Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nejc Haberman"'
Autor:
Gregor Rot, Zhen Wang, Ina Huppertz, Miha Modic, Tina Lenče, Martina Hallegger, Nejc Haberman, Tomaž Curk, Christian von Mering, Jernej Ule
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 1056-1067 (2017)
Summary: Many RNA-binding proteins (RBPs) regulate both alternative exons and poly(A) site selection. To understand their regulatory principles, we developed expressRNA, a web platform encompassing computational tools for integration of iCLIP and RNA
Externí odkaz:
https://doaj.org/article/4815e9673cbf448ab89319cf64b971f3
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1219-1236.e11 (2019)
Summary: Exon junction complex (EJC) assembles after splicing at specific positions upstream of exon-exon junctions in mRNAs of all higher eukaryotes, affecting major regulatory events. In mammalian cell cytoplasm, EJC is essential for efficient RNA
Externí odkaz:
https://doaj.org/article/cb5fd0009d9d456180c3ee1873d1c07b
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
We established a modified iCLIP protocol, called ‘read-through marking’, which facilitates the detection of cDNAs that have not been truncated upon encountering the RNA–peptide complex during reverse transcription (read-through cDNAs). A large
Externí odkaz:
https://doaj.org/article/70295121c16742988d0883eff9283d2d
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 555-568 (2014)
Nonsense-mediated mRNA decay (NMD) degrades different classes of mRNAs, including transcripts with premature termination codons (PTCs). The NMD factor SMG6 initiates degradation of substrate mRNAs by endonucleolytic cleavage. Here, we aim to delineat
Externí odkaz:
https://doaj.org/article/71be9370767a42578f089d78237b8eb8
Autor:
Jan Attig, Igor Ruiz de los Mozos, Nejc Haberman, Zhen Wang, Warren Emmett, Kathi Zarnack, Julian König, Jernej Ule
Publikováno v:
eLife, Vol 5 (2016)
Alu elements are retrotransposons that frequently form new exons during primate evolution. Here, we assess the interplay of splicing repression by hnRNPC and nonsense-mediated mRNA decay (NMD) in the quality control and evolution of new Alu-exons. We
Externí odkaz:
https://doaj.org/article/2742a90fdd0c4b8cacf59ddf90269aa9
Autor:
Nejc Haberman, Ina Huppertz, Jan Attig, Julian König, Zhen Wang, Christian Hauer, Matthias W. Hentze, Andreas E. Kulozik, Hervé Le Hir, Tomaž Curk, Christopher R. Sibley, Kathi Zarnack, Jernej Ule
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/8bb830280be149adbf06245c00271dd6
Autor:
Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Andrew M Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R Sibley, Aida Martinez-Sanchez, Boris Lenhard
SummaryThe 3’ untranslated region (3’UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis gene expression (CAGE), a method for the detection of capped 5’ ends of mRNAs, additionally re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bb72c57a82b070076c02347f548466
http://hdl.handle.net/10044/1/105362
http://hdl.handle.net/10044/1/105362
Autor:
Helen A. B. Paterson, Sijia Yu, Natalia Artigas, Miguel A. Prado, Nejc Haberman, Yi-Fang Wang, Andrew M. Jobbins, Elena Pahita, Joao Mokochinski, Zoe Hall, Maryse Guerin, Joao A. Paulo, Soon Seng Ng, Francesc Villarroya, Sheikh Tamir Rashid, Wilfried Le Goff, Boris Lenhard, Inês Cebola, Daniel Finley, Steven P. Gygi, Christopher R. Sibley, Santiago Vernia
Publikováno v:
Paterson, H, Yu, S, Artigas, N, Prado, M, Haberman, N, Wang, Y-F, Jobbins, A, Pahita, E, Mokochinski, J, Hall, Z, Guerin, M, Paulo, J, Ng, S S, Villarroya, F, Rashid, S T, Goff, W L, Lenhard, B, Cebola, I, Finley, D, Gygi, S, Sibley, C R & Vernia, S 2022, ' Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice ', Nature Metabolism, vol. 4, no. 12, pp. 1812-1829 . https://doi.org/10.1038/s42255-022-00681-y
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15b0846709fc330dbcd9cb12a59260e
https://hdl.handle.net/20.500.11820/eecc8061-8675-4351-a1e0-503b0c53cf98
https://hdl.handle.net/20.500.11820/eecc8061-8675-4351-a1e0-503b0c53cf98
Autor:
Andrew M Jobbins, Nejc Haberman, Natalia Artigas, Christopher Amourda, Helen A B Paterson, Sijia Yu, Samuel J I Blackford, Alex Montoya, Marian Dore, Yi-Fang Wang, Alessandro Sardini, Inês Cebola, Johannes Zuber, Sheikh Tamir Rashid, Boris Lenhard, Santiago Vernia
Pre-mRNA processing is an essential mechanism for the generation of mature mRNA and the regulation of gene expression in eukaryotic cells. While defects in pre-mRNA processing have been implicated in a number of diseases their involvement in metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7c74ceefaca47838e68740f698e465
http://hdl.handle.net/10044/1/100822
http://hdl.handle.net/10044/1/100822
Autor:
Lorenzo Piemonti, A. M. James Shapiro, Boris Lenhard, Isabelle Leclerc, Guy A. Rutter, Livia Lopez-Noriega, Nevena Cvetesic, Rebecca Callingham, Aida Martinez-Sanchez, Eelco J.P. de Koning, Timothy J. Pullen, Marie-Sophie Nguyen-Tu, Nejc Haberman, Grazia Pizza, Piero Marchetti, Paul Johnson
Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of {beta}-cell development and function. Consequently, the mis-expression of members of this group may contribute to the risk of type 2 diabetes (T2D). Here, we investigate roles for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a9381c2e341025f9bb56d5b80abe884
https://doi.org/10.1101/2020.07.17.209015
https://doi.org/10.1101/2020.07.17.209015