Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

Autor: Arkin, Michelle, Khare, S, Roach, SL, Barnes, SW, Hoepfner, D, Walker, JR, Chatterjee, AK, Neitz, RJ, Arkin, MR, McNamara, CW, Ballard, J

Publikováno v: Arkin, Michelle; Khare, S; Roach, SL; Barnes, SW; Hoepfner, D; Walker, JR; et al.(2015). Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6jq5m37t

© 2015 Khare et al.Unbiased phenotypic screens enable identification of small molecules that inhibit pathogen growth by unanticipated mechanisms. These small molecules can be used as starting points for drug discovery programs that target such mecha

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http://www.escholarship.org/uc/item/6jq5m37t

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The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2.

Autor: Suryawanshi RK; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA., Jaishankar P; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA., Correy GJ; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA., Rachman MM; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA., O'Leary PC; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Taha TY; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA., Zapatero-Belinchón FJ; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA., McCavittMalvido M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA., Doruk YU; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Stevens MGV; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Diolaiti ME; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Jogalekar MP; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Richards AL; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, CA., Montano M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA., Rosecrans J; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA., Matthay M; Department of Medicine, University of California San Francisco, San Francisco, CA., Togo T; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA., Gonciarz RL; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA., Gopalkrishnan S; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA., Neitz RJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA.; Small Molecule Discovery Center, University of California San Francisco, San Francisco, CA., Krogan NJ; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, CA., Swaney DL; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA.; Data Science and Biotechnology Institute, Gladstone Institutes, San Francisco, CA., Shoichet BK; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA., Ott M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA.; Department of Medicine, University of California San Francisco, San Francisco, CA.; Chan Zuckerberg Biohub- San Francisco, San Francisco, CA., Renslo AR; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA., Ashworth A; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 29. Date of Electronic Publication: 2024 Aug 29.

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.

Autor: Konstantinidou M; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco, California 94143, United States., Visser EJ; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Vandenboorn E; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Chen S; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco, California 94143, United States., Jaishankar P; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco, California 94143, United States., Overmans M; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Dutta S; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco, California 94143, United States., Neitz RJ; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco, California 94143, United States., Renslo AR; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco, California 94143, United States., Ottmann C; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Brunsveld L; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Arkin MR; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco, California 94143, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Sep 20; Vol. 145 (37), pp. 20328-20343. Date of Electronic Publication: 2023 Sep 07.

A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.

Autor: Kenanova DN; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco 94143, United States., Visser EJ; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Virta JM; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco 94143, United States., Sijbesma E; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Centorrino F; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Vickery HR; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco 94143, United States., Zhong M; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco 94143, United States., Neitz RJ; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco 94143, United States., Brunsveld L; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Ottmann C; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands., Arkin MR; Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco 94143, United States.

Publikováno v: ACS central science [ACS Cent Sci] 2023 Apr 18; Vol. 9 (5), pp. 937-946. Date of Electronic Publication: 2023 Apr 18 (Print Publication: 2023).