Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens.

Autor: Tse MW; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; These authors contributed equally., Zhu M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; These authors contributed equally., Peters B; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; These authors contributed equally., Hamami E; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111.; These authors contributed equally., Chen J; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Microbiology Graduate Program, Massachusetts Institute of Technology, Cambridge, MA 02139., Davis KP; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111., Nitz S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Tri-Institutional Program in Computational Biology and Medicine, New York, New York, 10065., Weller J; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Wellcome Sanger Institute, Hinxton, Saffron Walden CB10 1RQ, United Kingdom., Warrier T; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, 02114., Hunt DK; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Morales Y; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111., Kawate T; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, 02114., Gaulin JL; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Come JH; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Tango Therapeutics, Boston, MA, USA 02215., Hernandez-Bird J; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111., Huo W; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111., Neisewander I; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111., Kiessling LL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Hung DT; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, 02114.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Mecsas J; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111., Aldridge BB; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111.; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155., Isberg RR; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, & Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, 02111.; These authors are co-corresponding and contributed equally., Blainey PC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; These authors are co-corresponding and contributed equally.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 26. Date of Electronic Publication: 2024 Mar 26.