Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Neill J. Liptrott"'
Autor:
Christopher A. W. David, Jolanda P. Vermeulen, Sabrina Gioria, Rob J. Vandebriel, Neill J. Liptrott
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5491 (2024)
Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate primary cell responses, particularly those
Externí odkaz:
https://doaj.org/article/91d1378a3d6f4b019e6d0adab9491683
Autor:
Tamiris Borges da Silva, Erika Rendra, Christopher A.W. David, Karen Bieback, Michael J. Cross, Bettina Wilm, Neill J. Liptrott, Patricia Murray
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115624- (2023)
Mesenchymal stromal cells (MSCs) have been reported to display efficacy in a variety of preclinical models, but without long-term engraftment, suggesting a role for secreted factors, such as MSC-derived extracellular vesicles (EVs). MSCs are known to
Externí odkaz:
https://doaj.org/article/00ddb04672a54d6299c910861d8fcd0f
Application of KU812 cells for assessing complement activation related effects by nano(bio)materials
Autor:
Christopher A.W. David, Liset J.J. de la Fonteyne-Blankestijn, Jolanda P. Vermeulen, Alexander J. Plant-Hately, Rob J. Vandebriel, Neill J. Liptrott
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114841- (2023)
Immunocompatibility issues related to nano(bio)materials, particularly liposomal formulations, involving activation of the complement system have been relatively well described however, they highlight the importance of preclinical evaluation of such
Externí odkaz:
https://doaj.org/article/07a9661ea0b14f059161f112223a9567
Autor:
Francesco Amadeo, Vivien Hanson, Neill J. Liptrott, Bettina Wilm, Patricia Murray, Arthur Taylor
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114191- (2023)
Mesenchymal stromal cells (MSCs) are multipotent cells showing promise in pre-clinical studies and currently used in many clinical trials. The regenerative potential of MSCs is mediated, at least in part, by direct and indirect immunomodulatory proce
Externí odkaz:
https://doaj.org/article/0ee8345032e54761a82996e839ad3e9e
Publikováno v:
Stem Cells International, Vol 2023 (2023)
Mesenchymal stromal cells (MSCs) administered intravenously (IV) have shown efficacy in preclinical models of various diseases. This is despite the cells not reaching the site of injury due to entrapment in the lungs. The immunomodulatory properties
Externí odkaz:
https://doaj.org/article/63f630956f1d4cc4872dbc1193dc5b2c
Autor:
Paul Curley, James J. Hobson, Neill J. Liptrott, Edward Makarov, Amer Al-khouja, Lee Tatham, Christopher A. W. David, Helen Box, Megan Neary, Joanne Sharp, Henry Pertinez, David Meyers, Charles Flexner, Caren L. Freel Meyers, Larisa Poluektova, Steve Rannard, Andrew Owen
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1835 (2023)
Long-acting injectable (LAI) formulations promise to deliver patient benefits by overcoming issues associated with non-adherence. A preclinical assessment of semi-solid prodrug nanoparticle (SSPN) LAI formulations of emtricitabine (FTC) is reported h
Externí odkaz:
https://doaj.org/article/30c9897dc2e441029b763227a146a61d
Autor:
Christopher A. W. David, M. Estela del Castillo Busto, Susana Cuello-Nuñez, Heidi Goenaga-Infante, Michael Barrow, David G. Fernig, Patricia Murray, Matthew J. Rosseinsky, Andrew Owen, Neill J. Liptrott
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Background Safe and rational development of nanomaterials for clinical translation requires the assessment of potential biocompatibility. Autophagy, a critical homeostatic pathway intrinsically linked to cellular health and inflammation, has
Externí odkaz:
https://doaj.org/article/d61717e8f0e94888a27f085b19fa15aa
Autor:
Bethany J. Heaton, Rebecca L. Jensen, James Line, Christopher A.W. David, Danielle E. Brain, Amy E. Chadwick, Neill J. Liptrott
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 112999- (2022)
SLC2A1 mediates glucose cellular uptake; key to appropriate immune function. Our previous work has shown efavirenz and lopinavir exposure inhibits T cell and macrophage responses, to known agonists, likely via interactions with glucose transporters.
Externí odkaz:
https://doaj.org/article/bb9f778fdfa14bd19675b6dc69db0966
Autor:
Alexander J. Plant-Hately, Burcu Eryilmaz, Christopher A. W. David, Danielle E. Brain, Bethany J. Heaton, Yvonne Perrie, Neill J. Liptrott
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2470 (2022)
Lipidic nanoparticles (LNP), particularly liposomes, have been proven to be a successful and versatile platform for intracellular drug delivery for decades. Whilst primarily developed for small molecule delivery, liposomes have recently undergone a r
Externí odkaz:
https://doaj.org/article/f085aa3173a5414e81b0a43696c6b45f
Publikováno v:
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract Background Recent work has developed solid drug nanoparticles (SDNs) of efavirenz that have been demonstrated, preclinically, improved oral bioavailability and the potential to enable up to a 50% dose reduction, and is currently being studie
Externí odkaz:
https://doaj.org/article/a91bd83ee1774c0d8c663ec7db57dd63