Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Neile Grayson"'
Autor:
Bernard P. Kok, Andrea Galmozzi, Nicole K. Littlejohn, Verena Albert, Cristina Godio, Woojoo Kim, Sean M. Kim, Jeffrey S. Bland, Neile Grayson, Mingliang Fang, Wolfgang Meyerhof, Gary Siuzdak, Supriya Srinivasan, Maik Behrens, Enrique Saez
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 76-87 (2018)
Objectives: Extracts of the hops plant have been shown to reduce weight and insulin resistance in rodents and humans, but elucidation of the mechanisms responsible for these benefits has been hindered by the use of heterogeneous hops-derived mixtures
Externí odkaz:
https://doaj.org/article/13cb3da1ba1b47f5b449b4d9690f02b2
Autor:
Brian S. Finlin, Beibei Zhu, Bernard P. Kok, Cristina Godio, Philip M. Westgate, Neile Grayson, Robert Sims, Jeffrey S. Bland, Enrique Saez, Philip A. Kern
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
ObjectiveIn a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whe
Externí odkaz:
https://doaj.org/article/5761a5a060794efcac5c040af2039d0f
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87848 (2014)
AIMS/HYPOTHESIS: We developed KDT501, a novel substituted 1,3-cyclopentadione chemically derived from hop extracts, and evaluated it in various in vitro and in vivo models of diabetes and insulin sensitivity. METHODS: KDT501 was evaluated for anti-in
Externí odkaz:
https://doaj.org/article/68aebf4009a344cf9b52f2e227fe5fc1
Autor:
Enrique Saez, Supriya Srinivasan, Jeffrey S. Bland, Sean M. Kim, Neile Grayson, Gary Siuzdak, C. Godio, Woojoo Kim, Maik Behrens, Bernard P. Kok, Wolfgang Meyerhof, Verena Albert, Mingliang Fang, Andrea Galmozzi, Nicole K. Littlejohn
Publikováno v:
Molecular Metabolism, Vol 16, Iss, Pp 76-87 (2018)
Objectives: Extracts of the hops plant have been shown to reduce weight and insulin resistance in rodents and humans, but elucidation of the mechanisms responsible for these benefits has been hindered by the use of heterogeneous hops-derived mixtures
Bitter Taste Receptor Ligand Improves Metabolic and Reproductive Functions in a Murine Model of PCOS
Publikováno v:
Endocrinology. 160(1)
Polycystic ovary syndrome (PCOS) results from functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Cultured theca cells from polycystic ovaries of women with the most common form of PCOS overexpress most androgen producing
Autor:
Deanna M. Minich, Gary Darland, Robert H. Lerman, Jeffrey S. Bland, Joseph J. Lamb, Matthew L. Tripp, Neile Grayson
Publikováno v:
PharmaNutrition. 3:46-52
The lipophilic extracts of the common hops ( Humulus lupulus ) contain compounds that are readily modified to the family of isohumulones (e.g., iso - alpha acids). The isohumulones have been found to reduce metabolic inflammation and insulin resistan
Autor:
Beibei Zhu, Tania Boyechko, Brian S. Finlin, Philip A. Kern, Robert Sims, Neile Grayson, Jeffrey S. Bland, Dorothy Ross
Publikováno v:
Journal of the Endocrine Society
Context: KDT501 is an isohumulone drug that has demonstrated beneficial effects on metabolic parameters in mice. Objective: This study was intended to examine potential improvements in metabolism in humans. Design and Setting: Changes in carbohydrate
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e87848 (2014)
PLoS ONE, Vol 9, Iss 1, p e87848 (2014)
AIMS/HYPOTHESIS: We developed KDT501, a novel substituted 1,3-cyclopentadione chemically derived from hop extracts, and evaluated it in various in vitro and in vivo models of diabetes and insulin sensitivity. METHODS: KDT501 was evaluated for anti-in