Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Neil W. A. McGowan"'
Autor:
Rachel S. Cooper, Catherine Sutherland, Linda M. Smith, Graeme Cowan, Mark Barnett, Donna Mitchell, Colin McLean, Stuart Imlach, Alan Hayes, Sharon Zahra, Champa Manchanayake, Mark A. Vickers, Gerry Graham, Neil W. A. McGowan, Marc L. Turner, John D. M. Campbell, Alasdair R. Fraser
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Adoptive immunotherapy with Epstein–Barr virus (EBV)-specific T cells is an effective treatment for relapsed or refractory EBV-induced post-transplant lymphoproliferative disorders (PTLD) with overall survival rates of up to 69%. EBV-specific T cel
Externí odkaz:
https://doaj.org/article/0cb45f6c1180476fa75a74a1fdc66481
Autor:
Mario M. Zaiss, Christopher Hall, Neil W. A. McGowan, Rebecca Babb, Vikesh Devlia, Sébastien Lucas, Sajeda Meghji, Brian Henderson, Aline Bozec, Georg Schett, Jean‐Pierre David, Gabriel S. Panayi, Agamemnon E. Grigoriadis, Valerie M. Corrigall
Publikováno v:
ACR Open Rheumatology, Vol 1, Iss 6, Pp 382-393 (2019)
Objective The association between inflammation and dysregulated bone remodeling is apparent in rheumatoid arthritis and is recapitulated in the human tumor necrosis factor transgenic (hTNFtg) mouse model. We investigated whether extracellular binding
Externí odkaz:
https://doaj.org/article/04a0f51a530f4d1b9dd2c2df372d1a40
Autor:
Thomas Manship, Mark T. Macmillan, Francesca Moroni, John M. Campbell, Paul Noel Brennan, Alison Glover, Alasdair R. Fraser, John F. Dillon, Stuart J. Forbes, Neil W. A. McGowan, Neil Lachlan, David M. Morris, Marc Turner, Chloe Pass, Jonathan A. Fallowfield, Catriona Graham, Scott Semple
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open
Brennan, P N, MacMillan, M, Manship, T, Moroni, F, Glover, A, Graham, C, Semple, S, Morris, D M, Fraser, A R, Pass, C, McGowan, N W A, Turner, M L, Lachlan, N, Dillon, J F, Campbell, J D M, Fallowfield, J A & Forbes, S J 2021, ' Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) ', BMJ Open . https://doi.org/DOI: 10.1136/bmjopen-2021-053190
BMJ Open
Brennan, P N, MacMillan, M, Manship, T, Moroni, F, Glover, A, Graham, C, Semple, S, Morris, D M, Fraser, A R, Pass, C, McGowan, N W A, Turner, M L, Lachlan, N, Dillon, J F, Campbell, J D M, Fallowfield, J A & Forbes, S J 2021, ' Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) ', BMJ Open . https://doi.org/DOI: 10.1136/bmjopen-2021-053190
IntroductionLiver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or proregenerative medic
Autor:
John D.M. Campbell, Neil W. A. McGowan
Publikováno v:
Cell and Gene Therapy Insights. 5:727-738
Autor:
Richard K. Battle, Gwen Wilkie, Neil W. A. McGowan, Marc Turner, David M. Turner, Abhinav Mathur, Sajida Kazi, John D.M. Campbell, Mark A. Vickers, Emily Hargreaves, Kirsty Cheal, Neil Fraser
Publikováno v:
Haematologica. 104:e356-e359
Autor:
John Drain, Marc Turner, Kanna Ramaesh, Coral MacRury, Alison Glover, Neil W. A. McGowan, Ian Downing, Jane Pelly, Sanjay Mantry, Louis Nerurkar, Jacqueline Barry, Ashish Agrawal, Alasdair R. Fraser, Baljean Dhillon, Stephen B. Kaye, B. Cuthbertson, Emily Hargreaves, John D.M. Campbell, Anne P.M. Atkinson, Sajjad Ahmad, Carol Bienek, Margaret MacDonald
Publikováno v:
Stem Cells Translational Medicine
STEM CELLS TRANSLATIONAL MEDICINE
STEM CELLS TRANSLATIONAL MEDICINE
Limbal stem cell deficiency (LSCD) is a disease resulting from the loss or dysfunction of epithelial stem cells, which seriously impairs sight. Autologous limbal stem cell transplantation is effective in unilateral or partial bilateral disease but no
Autor:
Anne P.M. Atkinson, Benjamin J. Dwyer, Neil W. A. McGowan, Laura Bailey, Audrey Laurie, Paul Burgoyne, Stuart J. Forbes, John D. M. Campbell, Joanna Moore, Chloe Pass, Marc Turner, Alasdair R. Fraser, Akib Hamid
Publikováno v:
Cytotherapy
Fraser, A R, Pass, C, Burgoyne, P, Atkinson, A, Bailey, L, Laurie, A, W A McGowan, N, Hamid, A, Moore, J K, Dwyer, B J, Turner, M L, Forbes, S J & Campbell, J D M 2017, ' Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages : A novel cellular therapeutic for liver cirrhosis ', Cytotherapy . https://doi.org/10.1016/j.jcyt.2017.05.009
Fraser, A R, Pass, C, Burgoyne, P, Atkinson, A, Bailey, L, Laurie, A, W A McGowan, N, Hamid, A, Moore, J K, Dwyer, B J, Turner, M L, Forbes, S J & Campbell, J D M 2017, ' Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages : A novel cellular therapeutic for liver cirrhosis ', Cytotherapy . https://doi.org/10.1016/j.jcyt.2017.05.009
BACKGROUND AIMS: Autologous macrophage therapy represents a potentially significant therapeutic advance for the treatment of severe progressive liver cirrhosis. Administration of macrophages has been shown to reduce inflammation and drive fibrotic sc
Autor:
Catriona Graham, Alison Glover, Diana Julie Leeming, Benjamin J. Dwyer, Laura Bailey, Neil W. A. McGowan, Peter C. Hayes, Francesca Moroni, Joanna Moore, Emily Hargreaves, Stuart J. Forbes, Jonathan A. Fallowfield, Chloe Pass, Jacqueline Barry, Kishwar Musa, John D.M. Campbell, Stuart Doig, Donna Mitchell, Audrey Laurie, Marc Turner, Lisa Ritchie, Mette Juul Nielsen, Alasdair R. Fraser
Publikováno v:
Moroni, F, Dwyer, B, Graham, C, Pass, C, Bailey, L, Ritchie, L, Mitchell, D, Glover, A, Laurie, A, Doig, S, Hargreaves, E, Fraser, A R, Turner, M L, Campbell, J D M, McGowan, N W A, Barry, J, Moore, J K, Hayes, P C, Leeming, D J, Nielsen, M J, Musa, K, Fallowfield, J A & Forbes, S J 2019, ' Safety profile of autologous macrophage therapy for liver cirrhosis ', Nature Medicine, vol. 25, no. 10, pp. 1560–1565 . https://doi.org/10.1038/s41591-019-0599-8
Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We conducted a first-in-human, phase 1 dose-escalation trial of autologous macrophage therapy in nine adults with cirrhosis and a Model for End-Stage Liver Disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc9eab221386f055fcaef843b18027a
https://hdl.handle.net/20.500.11820/9e2a4316-c9a3-4140-a403-d4c936ddc679
https://hdl.handle.net/20.500.11820/9e2a4316-c9a3-4140-a403-d4c936ddc679
Autor:
Christopher C. West, Kay Hewit, Gerard J. Graham, John M. Campbell, Joanne C. Mountford, David Colligan, Kayleigh L. Thirlwell, Marc Turner, Shareen Forbes, Christopher Kelly, Kay Samuel, Laura Bailey, Nerea Cuesta-Gomez, John Casey, Neil W. A. McGowan
Publikováno v:
Cytotherapy. 22(12)
Background aims Mesenchymal stromal cells (MSCs) isolated from various tissues are under investigation as cellular therapeutics in a wide range of diseases. It is appreciated that the basic biological functions of MSCs vary depending on tissue source
Publikováno v:
Transfusion and Apheresis Science. 55:164-168
Blood Transfusion Services are striving to continually improve the efficacy and quality of their blood products whilst also simultaneously diversifying into novel cellular products. For this to be successful the relationships between the various arms