Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Neil Vasan"'
Autor:
Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113535- (2023)
Summary: The phosphoinositide 3-kinase p110α is an essential mediator of insulin signaling and glucose homeostasis. We interrogated the human serine, threonine, and tyrosine kinome to search for novel regulators of p110α and found that the Hippo ki
Externí odkaz:
https://doaj.org/article/a5e7df93b0a7464587f421f871a959bf
Autor:
Tahj Blow BS, Parker N. Hyde PhD, John N. Falcone MD, Aaron Neinstein MD, Neil Vasan MD, PhD, Ritika Chitkara MPAS, Maurice A. Hurd BA, Sagar Sardesai MBBS, Maryam B. Lustberg MD, MPH, James H. Flory MD, MSCE, Jeff S. Volek PhD, Marcus D. Goncalves MD, PhD
Publikováno v:
Integrative Cancer Therapies, Vol 20 (2021)
Alpelisib is a α-selective phosphatidylinositol 3-kinase (PI3K) inhibitor approved for treatment of postmenopausal women, and men, with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2–), PIK3CA-mutated, adv
Externí odkaz:
https://doaj.org/article/b81288c92b19435e8df3a6d05b91595f
Autor:
Jared L. Johnson, Tomer M. Yaron, Emily M. Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M. Cizin, Benjamin M. Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, Norbert F. Käufer, Maxim V. Dorovkov, Alexey G. Ryazanov, Yuichiro Takagi, Edward R. Kastenhuber, Marcus D. Goncalves, Benjamin D. Hopkins, Olivier Elemento, Dylan J. Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V. Hornbeck, Benjamin E. Turk, Michael B. Yaffe, Lewis C. Cantley
Publikováno v:
Nature. 613:759-766
Protein phosphorylation is one of the most widespread post-translational modifications in biology1,2. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and se
Autor:
Maurizio Scaltriti, Alexander Drilon, Andrea Ventura, Chandra S. Verma, Elisa de Stanchina, Moshe Elkabets, David M. Hyman, Jaclyn F. Hechtman, Alberto Bardelli, Barry S. Taylor, Sandra Misale, Uwe Rix, Yi Liao, Sankar Jagadeeshan, Ofra Novoplansky, Michael F. Berger, Alexander N. Gorelick, Neil Vasan, Ram Kannan, Benedetta Mussolin, Sabrina Arena, Yanyan Cai, Fan Wu, Srushti Kittane, Amaia Arruabarrena-Aristorena, Eneda Toska, Laura Baldino, Amanda Kulick, Sophie Shifman, Helen H. Won, Alison M. Schram, Srinivasaraghavan Kannan, Ji Eun Lee, Emiliano Cocco
On-target resistance to next-generation TRK inhibitors in TRK fusion–positive cancers is largely uncharacterized. In patients with these tumors, we found that TRK xDFG mutations confer resistance to type I next-generation TRK inhibitors designed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::807ca77bc7845326b9d1552aaed59835
https://doi.org/10.1158/2159-8290.c.6548215.v1
https://doi.org/10.1158/2159-8290.c.6548215.v1
Autor:
Maurizio Scaltriti, Alexander Drilon, Andrea Ventura, Chandra S. Verma, Elisa de Stanchina, Moshe Elkabets, David M. Hyman, Jaclyn F. Hechtman, Alberto Bardelli, Barry S. Taylor, Sandra Misale, Uwe Rix, Yi Liao, Sankar Jagadeeshan, Ofra Novoplansky, Michael F. Berger, Alexander N. Gorelick, Neil Vasan, Ram Kannan, Benedetta Mussolin, Sabrina Arena, Yanyan Cai, Fan Wu, Srushti Kittane, Amaia Arruabarrena-Aristorena, Eneda Toska, Laura Baldino, Amanda Kulick, Sophie Shifman, Helen H. Won, Alison M. Schram, Srinivasaraghavan Kannan, Ji Eun Lee, Emiliano Cocco
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509bc17855bc29dcb35a2805f934c54c
https://doi.org/10.1158/2159-8290.22536730.v1
https://doi.org/10.1158/2159-8290.22536730.v1
Autor:
Samuel F. Bakhoum, Benjamin Izar, Eileen E. Parkes, Alexander N. Shoushtari, Charles Swanton, Olivier Elemento, Jedd D. Wolchok, Simon N. Powell, Neil Vasan, Anusha Kalbasi, Shin-San Michael Su, Nadeem Riaz, Jorge S. Reis-Filho, Hannah Y. Wen, Taha Merghoub, Travis J. Hollmann, Benjamin J. DiPardo, Lee Gottesdiener, Chantal Pauli, Peng Li, Julie-Ann Cavallo, Princesca Dorsaint, Maria Laura Martin, Hao Wei Li, Rohan Bareja, Dhruva Biswas, Ieva Usaite, Kevin Litchfield, Sreeram Vallabhaneni, Johannes C. Melms, Matthew G. Hanna, Jacqueline A. James, Manuel Salto-Tellez, Matthew P. Humphries, Roshan K. Sriram, John Kwon, Sarah E. Bettigole, Walid K. Chatila, Ninjit Dhanota, Mercedes A. Duran, Jun Li
Supplementary Figures and Methods in PDF format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635ea996437975f580871317155e428c
https://doi.org/10.1158/2159-8290.22540268.v1
https://doi.org/10.1158/2159-8290.22540268.v1
Autor:
Maurizio Scaltriti, Alexander Drilon, Andrea Ventura, Chandra S. Verma, Elisa de Stanchina, Moshe Elkabets, David M. Hyman, Jaclyn F. Hechtman, Alberto Bardelli, Barry S. Taylor, Sandra Misale, Uwe Rix, Yi Liao, Sankar Jagadeeshan, Ofra Novoplansky, Michael F. Berger, Alexander N. Gorelick, Neil Vasan, Ram Kannan, Benedetta Mussolin, Sabrina Arena, Yanyan Cai, Fan Wu, Srushti Kittane, Amaia Arruabarrena-Aristorena, Eneda Toska, Laura Baldino, Amanda Kulick, Sophie Shifman, Helen H. Won, Alison M. Schram, Srinivasaraghavan Kannan, Ji Eun Lee, Emiliano Cocco
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92832fa930dda8cd6203069c5c7206c4
https://doi.org/10.1158/2159-8290.22536727.v1
https://doi.org/10.1158/2159-8290.22536727.v1
Autor:
Samuel F. Bakhoum, Benjamin Izar, Eileen E. Parkes, Alexander N. Shoushtari, Charles Swanton, Olivier Elemento, Jedd D. Wolchok, Simon N. Powell, Neil Vasan, Anusha Kalbasi, Shin-San Michael Su, Nadeem Riaz, Jorge S. Reis-Filho, Hannah Y. Wen, Taha Merghoub, Travis J. Hollmann, Benjamin J. DiPardo, Lee Gottesdiener, Chantal Pauli, Peng Li, Julie-Ann Cavallo, Princesca Dorsaint, Maria Laura Martin, Hao Wei Li, Rohan Bareja, Dhruva Biswas, Ieva Usaite, Kevin Litchfield, Sreeram Vallabhaneni, Johannes C. Melms, Matthew G. Hanna, Jacqueline A. James, Manuel Salto-Tellez, Matthew P. Humphries, Roshan K. Sriram, John Kwon, Sarah E. Bettigole, Walid K. Chatila, Ninjit Dhanota, Mercedes A. Duran, Jun Li
Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt inflammatory signaling while evading immune surveillance remains unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af51a233154e60a4e2bb2d77e8270d96
https://doi.org/10.1158/2159-8290.c.6549335
https://doi.org/10.1158/2159-8290.c.6549335
Autor:
Neil Vasan, Ethan S. Sokol, Timothy R. Wilson, Katherine E. Hutchinson, Jessica W. Chen, Maurizio Scaltriti, Lewis C. Cantley, Jeffrey Ross, Ruchita Rathod, Dexter X. Jin, Smruthy Sivakumar
Serine and threonine phosphoproteome of NIH-3T3 cells bearing PIK3CA E726K/H1047R vs H1047R.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8737d9ce5daf72b64bc91593d302e9
https://doi.org/10.1158/1078-0432.22490002
https://doi.org/10.1158/1078-0432.22490002
Autor:
Neil Vasan, Ethan S. Sokol, Timothy R. Wilson, Katherine E. Hutchinson, Jessica W. Chen, Maurizio Scaltriti, Lewis C. Cantley, Jeffrey Ross, Ruchita Rathod, Dexter X. Jin, Smruthy Sivakumar
Purpose:To comprehensively characterize tissue-specific and molecular subclasses of multiple PIK3CA (multi-PIK3CA) mutations and assess their impact on potential therapeutic outcomes.Experimental Design:We profiled a pan-cancer cohort comprised of 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3f3235ed5eaa112a1874926df2e217
https://doi.org/10.1158/1078-0432.c.6533080.v1
https://doi.org/10.1158/1078-0432.c.6533080.v1