Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Neil T. Umbreit"'
Autor:
Leena J. Laine, Jenni H.E. Mäki-Jouppila, Emma Kutvonen, Pekka Tiikkainen, Thomas K.M. Nyholm, Jerry F. Tien, Neil T. Umbreit, Ville Härmä, Lila Kallio, Trisha N. Davis, Charles L. Asbury, Antti Poso, Gary J. Gorbsky, Marko J. Kallio
Publikováno v:
Oncoscience
Hec1 (Highly expressed in cancer 1) resides in the outer kinetochore where it works to facilitate proper kinetochore-microtubule interactions during mitosis. Hec1 is overexpressed in various cancers and its expression shows correlation with high tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f0b0e1005faf9da232c6302ebf7d6f
https://doi.org/10.18632/oncoscience.549
https://doi.org/10.18632/oncoscience.549
Autor:
Jae ook Kim, Alex Zelter, Neil T Umbreit, Athena Bollozos, Michael Riffle, Richard Johnson, Michael J MacCoss, Charles L Asbury, Trisha N Davis
Publikováno v:
eLife, Vol 6 (2017)
Strong kinetochore-microtubule attachments are essential for faithful segregation of sister chromatids during mitosis. The Dam1 and Ndc80 complexes are the main microtubule binding components of the Saccharomyces cerevisiae kinetochore. Cooperation b
Externí odkaz:
https://doaj.org/article/5f0cbcb043664709adff91b73532d04c
The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma
Autor:
Tom W. Muir, Roodolph St. Pierre, Kristin Qian, Cigall Kadoch, Andrew R. D’Avino, Hayley J. Zullow, Neil T. Umbreit, Martin Filipovski, Evan B. Winter, Hyuk-Soo Seo, Matthew J. McBride, Jacob D. Jaffe, Sirano Dhe-Paganon, Hai T. Dao, Nazar Mashtalir, Alfredo M. Valencia
Publikováno v:
Nature Structural & Molecular Biology
Interactions between chromatin-associated proteins and the histone landscape play major roles in dictating genome topology and gene expression. Cancer-specific fusion oncoproteins, which display unique chromatin localization patterns, often lack clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06847854c5e90b2743888fc4ebbe7886
http://europepmc.org/articles/PMC7714695
http://europepmc.org/articles/PMC7714695
Autor:
Charles L. Asbury, Matthew P. Miller, Trisha N. Davis, Jae ook Kim, Abraham Gutierrez, Sue Biggins, Neil T. Umbreit
Publikováno v:
Current Biology
To ensure the faithful inheritance of DNA, a macromolecular protein complex called the kinetochore sustains the connection between chromosomes and force-generating dynamic microtubules during cell division. Defects in this process lead to aneuploidy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262a5c469a0f61a07ea3d0e7c31d1e0e
https://pubmed.ncbi.nlm.nih.gov/32946748
https://pubmed.ncbi.nlm.nih.gov/32946748
Autor:
Alan L Jiao, David Pellman, Jeffrey R. Haswell, Mary E. Piper, Roberto Perales, Frank J. Slack, Neil T. Umbreit, Scott Kennedy, Brian D. Adams
Publikováno v:
RNA. 25:352-363
The accurate inheritance of genetic material is a basic necessity in all domains of life and an unexpectedly large number of RNA processing factors are required for mitotic progression and genome stability. NRDE2 (nuclear RNAi defective-2) is an evol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc47b1fd7e22916abd02ed1bfb9c7fb
https://doi.org/10.1261/rna.069773.118
https://doi.org/10.1261/rna.069773.118
Autor:
Shruthi Viswanath, Ivan Rayment, Keenan C. Taylor, Mark Winey, King C. Yabut, Daniel Russel, Neil T. Umbreit, Seung Joong Kim, Eric G D Muller, Trisha N. Davis, Heather A. Van Epps, Massimiliano Bonomi, Javier Velázquez-Muriel, Vadim A. Klenchin, Janet B. Meehl, Michele H. Jones, Andrej Sali
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (23), pp.3298-3314. ⟨10.1091/mbc.E17-06-0397⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (23), pp.3298-3314. ⟨10.1091/mbc.E17-06-0397⟩
A model of the core of the yeast spindle pole body (SPB) was created by a Bayesian modeling approach that integrated a diverse data set of biophysical, biochemical, and genetic information. The model led to a proposed pathway for the assembly of Spc1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d80d8100f9d6de48e5db97b9e82a40
https://doi.org/10.1091/mbc.e17-06-0397
https://doi.org/10.1091/mbc.e17-06-0397
Publikováno v:
Current Biology. 27:R1228-R1231
Two recent papers report the activation of a pro-inflammatory response by cytoplasmic DNA from aberrant nuclear structures called micronuclei. The findings have implications for tumor immunity, immunotherapy biomarker discovery, and possibly the many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::272867c16eab9532dc8f1a3a888ce801
https://doi.org/10.1016/j.cub.2017.09.043
https://doi.org/10.1016/j.cub.2017.09.043
Autor:
Anna M. Cheng, Neil T. Umbreit, Luke D. Lynch, Alexander Spektor, Richard W. Tourdot, Lili Sun, Cheng-Zhong Zhang, Kim Judge, David Pellman, Thomas J. Mitchell, Logan J. Blaine, Hannah Almubarak
Genomic havoc from one fateful mistake Many human tumors display scrambled genomes that arise from two distinct mutational processes. The first, the chromosome breakage-fusion-bridge (BFB) cycle, produces gene amplification and genomic instability. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e57cbc83f97f575a2f7ce0546fa742
Autor:
Roodolph St. Pierre, Kristin Qian, Evan B. Winter, Hayley J. Zullow, Neil T. Umbreit, Tom W. Muir, Matthew J. McBride, Nazar Mashtalir, Martin Filipovski, Hai T. Dao, Andrew R. D’Avino, Alfredo M. Valencia, Cigall Kadoch, Jacob D. Jaffe, Sirano Dhe-Paganon, Hyuk-Soo Seo
Publikováno v:
Nature Structural & Molecular Biology. 28:118-118
A Correction to this paper has been published: https://doi.org/10.1038/s41594-020-00540-y.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3379df6f5014e2ae308a303261357b40
https://doi.org/10.1038/s41594-020-00540-y
https://doi.org/10.1038/s41594-020-00540-y
Autor:
Jerry F. Tien, Neil T. Umbreit, Trisha N. Davis, Charles L. Asbury, Daniel R. Gestaut, Tamir Gonen, Breanna S. Vollmar
Publikováno v:
Proceedings of the National Academy of Sciences. 109:16113-16118
The conserved Ndc80 complex is an essential microtubule-binding component of the kinetochore. Recent findings suggest that the Ndc80 complex influences microtubule dynamics at kinetochores in vivo. However, it was unclear if the Ndc80 complex mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc8c1fa985e9794449a6fe1431caf644
https://doi.org/10.1073/pnas.1209615109
https://doi.org/10.1073/pnas.1209615109