Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Neil Sweezey"'
Autor:
Meraj A. Khan, Armin Farahvash, David N. Douda, Johann-Christoph Licht, Hartmut Grasemann, Neil Sweezey, Nades Palaniyar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established. We hypothesized that stress-activated pro
Externí odkaz:
https://doaj.org/article/2755d4df15b743fba2daff2f45656a21
Autor:
Meraj A. Khan, Lijy M. Philip, Guillaume Cheung, Shawn Vadakepeedika, Hartmut Grasemann, Neil Sweezey, Nades Palaniyar
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pHe) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H+ ions reducing the intracellu
Externí odkaz:
https://doaj.org/article/1c38ff3e0d464930b977cba9019afec1
Autor:
Cristiane Naffah de Souza, Leandro C. D. Breda, Meraj A. Khan, Sandro Rogério de Almeida, Niels Olsen Saraiva Câmara, Neil Sweezey, Nades Palaniyar
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent
Externí odkaz:
https://doaj.org/article/400fe2efb70e4df690839379017641f2
Publikováno v:
Genes, Vol 10, Iss 3, p 183 (2019)
Genetic defects in cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to the establishment of infection in their lung. The inflammatory respons
Externí odkaz:
https://doaj.org/article/cc6f9e8cf3d6434195efd19187fa982d
Autor:
Lucy Perrem, Sanja Stanojevic, Michelle Shaw, Renee Jensen, Nancy McDonald, Sarah M. Isaac, Miriam Davis, Charles Clem, Julia Guido, Sylvia Jara, Lisa France, Melinda Solomon, Hartmut Grasemann, Valerie Waters, Neil Sweezey, Don B. Sanders, Stephanie D. Davis, Felix Ratjen
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 203:977-986
Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in preschool children with cystic fibrosis (CF), but its utility to identify and manage these events in school-ag...
Autor:
Lucy Perrem, Sanja Stanojevic, Michelle Shaw, Maryjess Pornillos, Julia Guido, Don B. Sanders, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Stephanie D Davis, Felix Ratjen
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
Patient-reported outcomes (PROs) are important outcome measures in research and clinical practice. This study describes the longitudinal variability the Cystic Fibrosis Questionnaire-Revised (CFQ-R) Respiratory score and the Chronic Respiratory Infec
Autor:
Lucy Perrem, Sanja Stanojevic, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Don B Sanders, Stephanie D Davis, Felix Ratjen
Publikováno v:
Thorax.
BackgroundThe limits of reproducibility of the lung clearance index (LCI) are higher in children with cystic fibrosis (CF) compared with healthy children, and it is currently unclear what defines a clinically meaningful change.MethodsIn a prospective
Autor:
Sanja Stanojevic, Sylvia Jara, Neil Sweezey, Melinda Solomon, Valerie Waters, R. Jensen, Hartmut Grasemann, Michelle Shaw, Charles Clem, Julia Guido, Felix Ratjen, Stephanie D. Davis
Publikováno v:
Clinical respiratory physiology, exercise and functional imaging.
Introduction: Increased equipment dead space relative to lung volume has been shown to impact multiple breath washout (MBW) outcomes (Benseler et al. Respirology, 2015). EcoMedics AG (Exhalyzer®D MBW device) recommends a weight-specific dead space r
Autor:
Sanja Stanojevic, R. Jensen, Sylvia Jara, Stephanie D. Davis, Julia Guido, Hartmut Grasemann, Valerie Waters, Neil Sweezey, Michelle Shaw, Melina Solomon, Charles Clem, Felix Ratjen, Lucy Perem, Db Sanders
Publikováno v:
Cystic fibrosis.
Background: Lung Clearance Index (LCI) is a sensitive measure of lung disease in children with cystic fibrosis (CF). The aim of this study was to determine whether there are modifiable factors that affect the course of lung disease during childhood.
Autor:
Melinda Solomon, R. Jensen, Michelle Shaw, Sylvia Jara, Sanja Stanojevic, Charles Clem, Hartmut Grasemann, Lucy Perrem, Don B. Sanders, Nancy Mcdonald, Neil Sweezey, Felix Ratjen, Sarah Isaac, Julia Guido, Stephanie Davies
Publikováno v:
Cystic fibrosis.
Background: We previously demonstrated that the lung clearance index (LCI) worsens with acute respiratory events (ARE) in preschool children with cystic fibrosis (CF) (Rayment, Thorax 2018). We are now describing the functional consequences of ARE in