Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Neil Sumner"'
Autor:
Tieguang Yao, Liangwei Wu, Craig S. Donald, Douglas Ferguson, Lei Wang, Andrew Pike, Jianyan Wang, Justin Cidado, Dedong Wu, Kurt Gordon Pike, Kumar Thakur, Chungang Gu, Calum Cook, James Horstick, Tyler Grebe, Theresa Proia, Darren Stead, Alexander Hird, Michelle Lamb, Wenlin Shao, Nichole O'Connell, Yun Jiang, Sudhir M. Hande, Bin Yang, Janet Hawkins, Barlaam Bernard Christophe, Neil Sumner, Melissa Vasbinder, Andrew D. Ferguson, Jane E. Moore, Jeffrey G. Varnes, Bryan Roberts, Maryann San Martin, Lisa Drew, Ujjal Sarkar, Allan Dishington, Chris De Savi, Robert Casella, Steve C. Glossop, Jane L. Holmes, Thomas M. McGuire
Publikováno v:
Journal of Medicinal Chemistry. 63:15564-15590
A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for survival. We report the optimization of a series of amidopyridines (from compound 2), focusing o
The use of analytical and preparative chromatographic separations is of vital importance to the drug discovery process. Rapid and flexible analytical and semipreparative methods are required for multiple applications including monitoring of reactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb906b45379d3e591200a7a3628d2bc9
https://doi.org/10.1016/b978-0-444-64070-3.00007-2
https://doi.org/10.1016/b978-0-444-64070-3.00007-2
Publikováno v:
Journal of Chromatography A. 1398:66-72
Countercurrent chromatography (CCC) is a form of liquid–liquid chromatography. It works by running one immiscible solvent (mobile phase) over another solvent (stationary phase) being held in a CCC column using centrifugal force. The concentration o
Autor:
Neil Sumner
Publikováno v:
Journal of Chromatography A. 1218:6107-6113
Experiments have been carried out to evaluate Counter Current Chromatography (CCC) as an alternative purification technique to preparative Reverse Phase High Performance Liquid Chromatography (RP-HPLC) for small molecule pharmaceuticals. The major dr
Publikováno v:
Journal of Chromatography A. 1218:6053-6060
Gradient elution in CCC is a powerful tool, which needs further systematic development to become robust and easy to use. The first attempt to build a correlation between gradient elution profile and distribution ratio (KD) values for model mixtures c
Autor:
Sarah J. Hunt, Christine Heys, Andrew A. Mortlock, Roger John Butlin, Alan C. Reid, Campbell Wilson, Colin Bath, Nicola D. Wright, Eric Tang, Elaine Whiting, Neil Sumner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1399-1402
A series of novel sulphonamides have been discovered which show high affinity and selectivity for the endothelin ETA receptor. N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide (18) is the most widely investig
Publikováno v:
Tetrahedron Letters. 41:3197-3198
The novel regioselective substitution of 2,3-dichloro-6-amino-quinoxaline is described. A range of nucleophiles were used to provide 2,3-disubstituted-6-aminoquinoxalines with complementary regiochemistry to that obtainable using published methodolog