Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Neil Segil"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprisin
Externí odkaz:
https://doaj.org/article/3b245ce5a0af4541b0ad27a030592191
Autor:
Tuo Shi, Marielle O Beaulieu, Lauren M Saunders, Peter Fabian, Cole Trapnell, Neil Segil, J Gage Crump, David W Raible
Publikováno v:
eLife, Vol 12 (2023)
A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life. While a comp
Externí odkaz:
https://doaj.org/article/453e461ae07245579ef96440d47eaab7
Autor:
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 11 (2022)
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression in the developing cochlea can efficiently induce hair cell regeneration
Externí odkaz:
https://doaj.org/article/4cbcd933e07d46508ec37fe3ede0949c
Autor:
Litao Tao, Neil Segil
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Sensory hair cell death caused by the ototoxic side effects of many clinically used drugs leads to permanent sensorineural hearing loss in patients. Aminoglycoside antibiotics are widely used and well-known for their ototoxicity, but the molecular me
Externí odkaz:
https://doaj.org/article/a1ea7f94ba7549cd890cd30d093ecef2
Autor:
Nathaniel Kastan, Ksenia Gnedeva, Theresa Alisch, Aleksandra A. Petelski, David J. Huggins, Jeanne Chiaravalli, Alla Aharanov, Avraham Shakked, Eldad Tzahor, Aaron Nagiel, Neil Segil, A. J. Hudspeth
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Although Hippo signaling restricts regeneration in many mammalian organs, the pharmaceutical tools available to modulate the pathway have been limited. Here, the authors report a small molecule that may inhibit a key element in the Hippo cascade and
Externí odkaz:
https://doaj.org/article/a9dbde1730a749f6acae7a54edd1e572
Autor:
Pengfei Xu, Haoze V Yu, Kuo-Chang Tseng, Mackenzie Flath, Peter Fabian, Neil Segil, J Gage Crump
Publikováno v:
eLife, Vol 10 (2021)
The specification of cartilage requires Sox9, a transcription factor with broad roles for organogenesis outside the skeletal system. How Sox9 and other factors gain access to cartilage-specific cis-regulatory regions during skeletal development was u
Externí odkaz:
https://doaj.org/article/c37764b2fb684e898bc0cc0357e2be79
Autor:
Louise Menendez, Talon Trecek, Suhasni Gopalakrishnan, Litao Tao, Alexander L Markowitz, Haoze V Yu, Xizi Wang, Juan Llamas, Chichou Huang, James Lee, Radha Kalluri, Justin Ichida, Neil Segil
Publikováno v:
eLife, Vol 9 (2020)
The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfu
Externí odkaz:
https://doaj.org/article/6c860cc9943b4f488fa43d0ff80850e3
Autor:
Camilla S. Teng, Hai-Yun Yen, Lindsey Barske, Bea Smith, Juan Llamas, Neil Segil, John Go, Pedro A. Sanchez-Lara, Robert E. Maxson, J. Gage Crump
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Whereas Jagged1-Notch2 signaling is known to pattern the sensorineural components of the inner ear, its role in middle ear development has been less clear. We previously reported a role for Jagged-Notch signaling in shaping skeletal elements
Externí odkaz:
https://doaj.org/article/8e338a76f99742b7ba7c7902ebdbc3e9
Autor:
Hsin-I Jen, Matthew C Hill, Litao Tao, Kuanwei Sheng, Wenjian Cao, Hongyuan Zhang, Haoze V Yu, Juan Llamas, Chenghang Zong, James F Martin, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 8 (2019)
The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of hearing. In contrast, the adult vestibular system can produce new hair cells in response to damage, or by reprogramming of supporting cells with the hair cell
Externí odkaz:
https://doaj.org/article/627c72e39e6e4cba80400a301229c433
Autor:
Fatih Semerci, William Tin-Shing Choi, Aleksandar Bajic, Aarohi Thakkar, Juan Manuel Encinas, Frederic Depreux, Neil Segil, Andrew K Groves, Mirjana Maletic-Savatic
Publikováno v:
eLife, Vol 6 (2017)
Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor,
Externí odkaz:
https://doaj.org/article/37cf9c79636245ebb92a61c96e350631