Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Neil S. Cutshall"'
Autor:
László Ürögdi, Alex Rohde, Jennifer Lynn Gage, Sasha Gragerov, György Dormán, Rene Onrust, Vince Florio, Neil S. Cutshall, Derek Johnston, Andrew Osnowski, Harbol Kevin L, Thomas Neil Wheeler, Lee Mitchell, Wendy MacDonald
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4155-4159
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e228427176a466f0fe79d22fac4b0b4
https://doi.org/10.1016/j.bmcl.2011.05.100
https://doi.org/10.1016/j.bmcl.2011.05.100
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3374-3379
Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a983a675bfc864c862f5f964fb7af233
https://doi.org/10.1016/j.bmcl.2005.05.034
https://doi.org/10.1016/j.bmcl.2005.05.034
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1517-1520
A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae822e7e0262f938b0a6ba41ee7cf32
https://doi.org/10.1016/s0960-894x(02)00188-9
https://doi.org/10.1016/s0960-894x(02)00188-9
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1951-1954
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba17a58c6eb5ed89e45cb0c906a71863
https://doi.org/10.1016/s0960-894x(01)00326-2
https://doi.org/10.1016/s0960-894x(01)00326-2
Publikováno v:
Journal of the American Chemical Society. 119:2404-2419
A general synthetic route to the set of polyhydroxylated agarofurans that comprise the core structures of esters present in plants of the Celastraceae family has been devised. The pathway is exemplified with total syntheses of (±)-3,4-dideoxymaytol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dc8fbe62c5a9d122b6890786d6abad2
https://doi.org/10.1021/ja963567h
https://doi.org/10.1021/ja963567h
Autor:
Lauren Hamilton, Rene Onrust, Thomas Neil Wheeler, Charles Prince Zuta, Sasha Gragerov, Alex Rohde, Shawn McKee, Neil S. Cutshall, Jennifer Lynn Gage, Vince Florio, Harbol Kevin L, Galina Gragerova, Hui-Rong Shen
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86d367c4f6331c08078f09eadeaaf6b
https://pubmed.ncbi.nlm.nih.gov/22841436
https://pubmed.ncbi.nlm.nih.gov/22841436
Publikováno v:
Tetrahedron Letters. 35:6639-6642
A method for the conversion of a triol to a tetrahydrothiophene is described in which the key step involves ring cleavage of a cyclic carbonate with loss of carbon dioxide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f338d1af0669f737afee0668b5601c69
https://doi.org/10.1016/s0040-4039(00)73455-1
https://doi.org/10.1016/s0040-4039(00)73455-1
Publikováno v:
ChemInform. 26
A method for the conversion of a triol to a tetrahydrothiophene is described in which the key step involves ring cleavage of a cyclic carbonate with loss of carbon dioxide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdc0adc1f71f0ed4e83b8a668376c919
https://doi.org/10.1002/chin.199505287
https://doi.org/10.1002/chin.199505287
Publikováno v:
ChemInform. 28
A general synthetic route to the set of polyhydroxylated agarofurans that comprise the core structures of esters present in plants of the Celastraceae family has been devised. The pathway is exemplified with total syntheses of (±)-3,4-dideoxymaytol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5bd06a44647d796ba9cb656e21434e1
https://doi.org/10.1002/chin.199725183
https://doi.org/10.1002/chin.199725183
Publikováno v:
ChemInform. 32
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-α-driven human neutrophil chemotaxis. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba04a5c732793091a2dae9de5c0e487
https://doi.org/10.1002/chin.200146132
https://doi.org/10.1002/chin.200146132