Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Neil Roy Curtis"'
Publikováno v:
Tetrahedron Letters. 47:2635-2638
8-Azabicyclo[3.2.1]oct-3-en-2-ones were prepared by asymmetric 1,3-dipolar cycloadditions of homochiral pyridinium betaine 4 . Excellent diastereofacial selectivity was achieved for the major 6-exo cycloadducts. The absolute stereochemistry of cycloa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d64b145f5209e64649333852f4845c18
https://doi.org/10.1016/j.tetlet.2006.02.005
https://doi.org/10.1016/j.tetlet.2006.02.005
Autor:
Rodney A. Bednar, Roger M. Freidinger, John A. McCauley, Keith A. Wafford, David A. Claremon, Christopher F. Claiborne, Brian E. Libby, Stuart R. Michelson, Alison J. Macaulay, Nigel J. Liverton, Thomas M. Connolly, Bohumil Bednar, Kenneth S. Koblan, Stanley L. Gaul, Scott D. Mosser, Joseph J. Lynch, Cindra L. Condra, Gary L. Stump, Helen J. Diggle, Janusz Jozef Kulagowski, Kenneth D. Anderson, Neil Roy Curtis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:697-700
A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a carrageenan-induced rat hyperalgesia model of pain and shows no motor coordination side effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd299167537625261e03641a62d5a8a0
https://doi.org/10.1016/s0960-894x(02)01061-2
https://doi.org/10.1016/s0960-894x(02)01061-2
Autor:
Andrew N. Payne, Andrew B. Holmes, Craig L. Francis, Neil Roy Curtis, Jonathan W. Burton, Miles S. Congreve, S. Y. Frankie Mak
Publikováno v:
Synthesis. :3199-3201
A synthesis of the halogenated medium-ring ether natural product (+)-obtusenyne is reported utilizing a Claisen rearrangement and an intramolecular hydrosilation as key steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173b686cb74f8e79a76d22c10953f27c
https://doi.org/10.1055/s-2005-918470
https://doi.org/10.1055/s-2005-918470
Autor:
George R. Marshall, Michael Rowley, Sarah Grimwood, Paul D. Leeson, Mark Peter Ridgill, Neil Roy Curtis, Janusz Jozef Kulagowski, Ian M. Mawer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1145-1150
A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::462c88d9948701fbd4341f4906cd036b
https://doi.org/10.1016/0960-894x(96)00187-4
https://doi.org/10.1016/0960-894x(96)00187-4
Autor:
Janet J. Maguire, Raymond Baker, Stephen Young, Brian John Williams, Daniel F. Veber, Neil Roy Curtis, Alexander T. McKnight
Publikováno v:
Journal of Medicinal Chemistry. 36:2-10
Twenty homodetic cyclic peptides based on the C-terminal sequence of substance P were prepared (Table I) by a combination of solid-phase techniques and cyclizations using azide coupling procedures. Incorporation of dipeptide mimics based on substitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae5390c2a27c5887f4f7513db4c5ac2
https://doi.org/10.1021/jm00053a001
https://doi.org/10.1021/jm00053a001
Publikováno v:
ChemInform. 22
The homochiral lactone ( 5 ) and the oxazolidinone ( 9 ), together with the phosphoniumsalt ( 15 ), serve as key building blocks for the enantioselective synthesis of the ( Z )-bis(silyloxy) ester ( 17 ), whose photochemical conversion into the ( E )
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aebdfcf9ff7ec49b496e029fd5f431a1
https://doi.org/10.1002/chin.199151324
https://doi.org/10.1002/chin.199151324
Publikováno v:
ChemInform. 22
An advanced intermediate for the synthesis of the Laurencia oxonane natural product obtusenyne 1 . namely the unsaturated nine-membered lactone 3 , was efficiently prepared in seven steps from ( E )-3-hexenoic acid 7. The key transformation was the C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994029e767c6104aebf129fddfa719f1
https://doi.org/10.1002/chin.199150234
https://doi.org/10.1002/chin.199150234
Autor:
Ian M. Mawer, Janusz Jozef Kulagowski, George R. Marshall, Mark Peter Ridgill, Paul D. Leeson, Michael Rowley, Neil Roy Curtis, Sarah Grimwood
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183cbbdb07e37b91a700477e13b06c14
https://doi.org/10.1002/chin.199637262
https://doi.org/10.1002/chin.199637262
Publikováno v:
ChemInform. 32
Complementary stereoselective syntheses of individual C3 epimers of the NK-1 receptor antagonist precursor 1 have been developed. Both diastereomers were derived from the common intermediate 3; introduction of the 3S stereocenter in 1a was achieved t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d60212518581db68e58a22832560d5
https://doi.org/10.1002/chin.200126139
https://doi.org/10.1002/chin.200126139
Publikováno v:
Tetrahedron. 47:7171-7178
An advanced intermediate for the synthesis of the Laurencia oxonane natural product obtusenyne 1 . namely the unsaturated nine-membered lactone 3 , was efficiently prepared in seven steps from ( E )-3-hexenoic acid 7. The key transformation was the C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a46d5b77c5eb874bc160eadd998ced9
https://doi.org/10.1016/s0040-4020(01)96169-1
https://doi.org/10.1016/s0040-4020(01)96169-1