Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Neil R. Stokes"'
Autor:
Amanda Lyons, James Kirkham, Kevin Blades, David Orr, Elizabeth Dauncey, Oliver Smith, Emma Dick, Rolf Walker, Teresa Matthews, Adam Bunt, Jonathan Finlayson, Ian Morrison, Victoria J. Savage, Emmanuel Moyo, Hayley S. Butler, Rebecca Newman, Nicola Ooi, Andrew Smith, Cédric Charrier, Andrew J. Ratcliffe, Neil R. Stokes, Stuart Best, Anne-Marie Salisbury, Mark Craighead, Ian R. Cooper
Publikováno v:
Bioorganicmedicinal chemistry letters. 65
There is an increasingly urgent and unmet medical need for novel antibiotic drugs that tackle infections caused by multidrug-resistant (MDR) pathogens. Novel bacterial type II topoisomerase inhibitors (NBTIs) are of high interest due to limited cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da721e70bec2ab77ddb3d96dcd4b4616
https://pubmed.ncbi.nlm.nih.gov/35231579
https://pubmed.ncbi.nlm.nih.gov/35231579
Autor:
Andrew J. Ratcliffe, Nicola Ooi, Neil R. Stokes, Richard Metzger, Victoria J. Savage, Henry Forward, David McGarry, Emmanuel Moyo, Cedric Charrier, Jonathan Cheung, Rolf Peter Walker, Ian R. Cooper, Anne-Marie Salisbury
Publikováno v:
Journal of Antimicrobial Chemotherapy. 71:2831-2839
OBJECTIVES: To evaluate the in vitro biological properties of a novel class of isothiazolone inhibitors of the bacterial type II topoisomerases. METHODS: Inhibition of DNA gyrase and topoisomerase IV activity was assessed using DNA supercoiling and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b43f52e1ea3e514df62ad0be38b1aa
https://doi.org/10.1093/jac/dkw228
https://doi.org/10.1093/jac/dkw228
Autor:
Andrew J. Ratcliffe, Ian R. Cooper, David McGarry, John Maclean, William J. Kerr, Emmanuel Moyo, Cedric Charrier, Anne-Marie Salisbury, Victoria J. Savage, Rolf Peter Walker, Mark Pichowicz, Catherine E. Warrilow, David M. Lindsay, Andrew Smith, Neil R. Stokes
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(17)
According to the World Health Organization (WHO), approximately 1.7 million deaths per year are caused by tuberculosis infections. Furthermore, it has been predicted that, by 2050, antibacterial resistance will be the cause of approximately 10 millio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5029a39eec2b6dcf0e83001d4c74867c
https://pubmed.ncbi.nlm.nih.gov/30122228
https://pubmed.ncbi.nlm.nih.gov/30122228
Autor:
Nathan Chaffer-Malam, Gary Nelson, Thomas Duffy, Cedric Charrier, Ralph Sigerson, Jonathan Cheung, Anne Marie Salisbury, David McGarry, Rebecca Newman, Ian R. Cooper, Stuart A. Best, Richard Metzger, Emmanuel Moyo, Mark Craighead, Mark Pichowicz, Hayley S. Butler, Victoria J. Savage, Neil R. Stokes, Nicola Ooi, Andrew J. Ratcliffe
The novel bacterial topoisomerase inhibitor class is an investigational type of antibacterial inhibitor of DNA gyrase and topoisomerase IV that does not have cross-resistance with the quinolones. Here, we report the evaluation of the in vitro propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08c3f1b0cca7ea9b5b22c7bea41547a
https://strathprints.strath.ac.uk/60125/1/Charrier_etal_AAC_2017_Novel_bacterial_topoisomerase_inhibitors_with_potent_broad_spectrum_activity.pdf
https://strathprints.strath.ac.uk/60125/1/Charrier_etal_AAC_2017_Novel_bacterial_topoisomerase_inhibitors_with_potent_broad_spectrum_activity.pdf
Autor:
Alastair Logan, James T Palmer, B. Narasinga Rao, Neil R. Stokes, Ian Collins, Tarun Shukla, James M. Bennett, Anil K Srivastava, Paul Lancett, Leigh Ford, Pitt Gary Robert William, Helena Thomaides-Brears, Lorraine C. Axford, Stephanie Barker, Anju Yadav, Amit Kumar Singh, David T. Davies, Michael Blair, Craig J. Morton, David J. Haydon, Carlie T. Gannon, Daniel A. Offermann, Christopher J. Lunniss
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4215-4222
A series of dual-targeting, alcohol-containing benzothiazoles has been identified with superior antibacterial activity and drug-like properties. Early lead benzothiazoles containing carboxylic acid moieties showed efficacy in a well-established in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56375c1a64d7f34eec61285f25026252
https://doi.org/10.1016/j.bmcl.2014.07.037
https://doi.org/10.1016/j.bmcl.2014.07.037
Autor:
Ian Collins, Pramod K. Chauhan, Neil R. Stokes, Anu Mahajan, Anil K Srivastava, Mahipal Singh, Anju Yadav, James M. Bennett, Leanne MacLeod, Paul Lancett, Yashodanand Nandan Nayal, David T. Davies, Narendra Nayal, Maruti Gavade, David J. Haydon, Rebecca Macdonald, Nicola Baker, Jeffrey Peter Mitchell, Lloyd George Czaplewski, Pitt Gary Robert William, Dushyant Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:353-359
The design, synthesis and structure-activity relationships of a series of oxazole-benzamide inhibitors of the essential bacterial cell division protein FtsZ are described. Compounds had potent anti-staphylococcal activity and inhibited the cytokinesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddbd9a97bd9de9b500efee80df242b4
https://doi.org/10.1016/j.bmcl.2013.11.002
https://doi.org/10.1016/j.bmcl.2013.11.002
Autor:
Jeffrey Peter Mitchell, David J. Haydon, Hilary Peasley, Lloyd George Czaplewski, Narendra Nayal, Alastair Logan, Joanne Berry, Anil K. Srivastava, Anju Yadav, Ian Collins, Neil R. Stokes, James M. Bennett, Rebecca Macdonald, Nicola Baker, Leanne MacLeod
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:317-325
The bacterial cell division protein FtsZ is an attractive target for small-molecule antibacterial drug discovery. Derivatives of 3-methoxybenzamide, including compound PC190723, have been reported to be potent and selective antistaphylococcal agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a9b083bc874958b03fddf8bb95cf0f
https://doi.org/10.1128/aac.01580-12
https://doi.org/10.1128/aac.01580-12
Autor:
Gary Nelson, Henry Forward, David McGarry, Jonathan Cheung, Andrew J. Ratcliffe, James Kirkham, Mark Craighead, Cedric Charrier, Zoe Gault, Ian R. Cooper, Catherine E. Warrilow, John Maclean, Emmanuel Moyo, Neil R. Stokes, Andrew J. McCarroll, Anne-Marie Salisbury, Victoria J. Savage, Mark Pichowicz, Stuart A. Best, Diarmaid Hughes, Rolf Peter Walker, Richard Metzger, Sha Cao
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(17)
There is an urgent and unmet medical need for new antibacterial drugs that tackle infections caused by multidrug-resistant (MDR) pathogens. During the course of our wider efforts to discover and exploit novel mechanism of action antibacterials, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784efa1acabfb498190a7bff89f4ca76
https://pubmed.ncbi.nlm.nih.gov/27499455
https://pubmed.ncbi.nlm.nih.gov/27499455
Autor:
Andrew J. Ratcliffe, Mark Craighead, Neil R. Stokes, Nathan Chaffer-Malam, Cedric Charrier, Gary M. Noonan, Sarfraz Mohmed, Victoria J. Savage, Stuart A. Best, Anthony Huxley, Ralph Kirk, Helen Box, Anne-Marie Salisbury
Publikováno v:
Antimicrobial agents and chemotherapy. 60(9)
There is an urgent need for new antibiotics to treat multidrug-resistant Neisseria gonorrhoeae . In this report, the microbiology, in vivo pharmacokinetics, and efficacy of REDX05931, a representative novel tricyclic topoisomerase inhibitor, were eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95143d8d2a655c3dcce17fd32e001199
https://pubmed.ncbi.nlm.nih.gov/27324777
https://pubmed.ncbi.nlm.nih.gov/27324777
Autor:
Susan Shirley Black, Akiko Rasmussen, Tim Rasmussen, Samantha Miller, Michelle D. Edwards, Ian R. Booth, Neil R. Stokes, Terri-Leigh Stephen
Publikováno v:
Channels
Mechanosensitive channels sense elevated membrane tension that arises from rapid water influx occurring when cells move from high to low osmolarity environments (hypoosmotic shock). These non-specific channels in the cytoplasmic membrane release osmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1200d0f73c7e4bacd778f743bcaee90
https://doi.org/10.4161/chan.20998
https://doi.org/10.4161/chan.20998