Výsledky vyhledávání - "Neil R. McLay"

Diastereo- and enantio-selectivity in the Pictet–Spengler reaction

Autor: Colin D. Reynolds, Sarah J. Palmer, Sean P. Hollinshead, Stephen N. Prince, S. D. Wood, Neil R. McLay, Keith M. Morgan, Patrick D. Bailey

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :431-439

The factors that control the relative and absolute stereochemistry of 1,3-disubstituted and 1,2,3-trisubstituted tetrahydro-β-carbolines formed via the Pictet–Spengler reaction are discussed. In particular, the stereochemical factors that lead to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::608a2585ddee3fa1e4a1cde3b65b1c5a
https://doi.org/10.1039/p19930000431

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Asymmetric synthesis of indole alkaloids from (L)-tryptophan: formal syntheses of (-)-koumine, (-)-taberpsychine & (-)-koumidine

Autor: Patrick D. Bailey, Neil R. McLay

Publikováno v: Tetrahedron Letters. 32:3895-3898

The reaction of (L)-tryptophan methyl ester with methyl 4-oxobutanoate under conditions of kinetic control gave a high yield of the cis -1,3-disubstituted tetrahydro-β-carboline (6); a simple five step procedure allowed this to be transformed into t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4db46c2700c2acfa71e5f6ae3f786d2
https://doi.org/10.1016/s0040-4039(00)79407-x

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An asymmetric route to the demethoxy-fumitremorgins

Autor: Sean P. Hollinshead, Patrick D. Bailey, Judith H. Everett, Neil R. McLay, Federico Giordano, Colin D. Reynolds, S. D. Wood

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :451

By use of a modified Pictet–Spengler reaction under conditions of kinetic control, the optically pure cis-1,3-disubstituted tetrahydro-β-carboline 21a was prepared from L-tryptophan; this generated a key tricyclic unit that possessed the correct r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::210bd6560e29ca1e877d6d45701d2dc0
https://doi.org/10.1039/p19930000451

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A stereoselective entry to the fumitremorgins

Autor: Patrick D. Bailey, Sean P. Hollinshead, Neil R. McLay

Publikováno v: Tetrahedron Letters. 30:6421-6422

The reaction of ( L )-tryptophan methyl ester with butynone yields a key cis -1,3-disubstituted-tetrahydro-β-carboline (3), simple modification of which gives access to the skeleton of the Fumitremorgin alkaloids.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97a22c19b6ab5bdf7852e7d88903d8e7
https://doi.org/10.1016/s0040-4039(01)93911-5

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