Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Neil Q. Mcdonald"'
Autor:
Sarah E. Conduit, Wayne Pearce, Amandeep Bhamra, Benoit Bilanges, Laura Bozal-Basterra, Lazaros C. Foukas, Mathias Cobbaut, Sandra D. Castillo, Mohammad Amin Danesh, Mahreen Adil, Arkaitz Carracedo, Mariona Graupera, Neil Q. McDonald, Peter J. Parker, Pedro R. Cutillas, Silvia Surinova, Bart Vanhaesebroeck
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the proc
Externí odkaz:
https://doaj.org/article/73d0a1177d1d4ad6bd109cda96644ef1
Autor:
Elena R. Rhymes, Andrew P. Tosolini, Alexander D. Fellows, William Mahy, Neil Q. McDonald, Giampietro Schiavo
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-11 (2022)
Abstract Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1G93A mice. Evidence suggests that rescuing these deficits prevents disease progression, stops
Externí odkaz:
https://doaj.org/article/0fdffd993fc54602a801ffc8fbe72a71
Autor:
Silvia Martini, Khalil Davis, Rupert Faraway, Lisa Elze, Nicola Lockwood, Andrew Jones, Xiao Xie, Neil Q. McDonald, David J. Mann, Alan Armstrong, Jernej Ule, Peter J. Parker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of ch
Externí odkaz:
https://doaj.org/article/d5e625f8ebda47a580e2c0dff47b3aba
Autor:
Morgan Jones, Fabienne Beuron, Aaron Borg, Andrea Nans, Christopher P. Earl, David C. Briggs, Ambrosius P. Snijders, Maureen Bowles, Edward P. Morris, Mark Linch, Neil Q. McDonald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The endonuclease XPF-ERCC1 is a key component of the repair machinery to process both intra-strand and inter-strand DNA crosslinks. Here the authors present the cryo-EM structures of DNA-free and DNA-bound human XPF-ERCC1 and find that DNA-free XPF-E
Externí odkaz:
https://doaj.org/article/92077ba79c5f4633a25574477d6776b9
Autor:
Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald, Koichi Goto
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Mechanisms of acquired resistance to RET tyrosine kinase inhibitors in lung cancers are largely unknown. Here, the authors report in a lung adenocarcinoma patient harboring a CCDC6-RET mutation in the RET kinase (S904F) that results in resistance to
Externí odkaz:
https://doaj.org/article/5dda588c6b064bfcbe3ac0b3c008bd63
Autor:
Iván Plaza-Menacho, Karin Barnouin, Rachael Barry, Annabel Borg, Mariam Orme, Rakhee Chauhan, Stephane Mouilleron, Rubén J. Martínez-Torres, Pascal Meier, Neil Q. McDonald
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3319-3332 (2016)
Receptor tyrosine kinases exhibit a variety of activation mechanisms despite highly homologous catalytic domains. Such diversity arises through coupling of extracellular ligand-binding portions with highly variable intracellular sequences flanking th
Externí odkaz:
https://doaj.org/article/d79f670d6e0b48388c49a0287b96fbce
Autor:
Kerry M. Goodman, Svend Kjær, Fabienne Beuron, Phillip P. Knowles, Agata Nawrotek, Emily M. Burns, Andrew G. Purkiss, Roger George, Massimo Santoro, Edward P. Morris, Neil Q. McDonald
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1894-1904 (2014)
The RET receptor tyrosine kinase is essential to vertebrate development and implicated in multiple human diseases. RET binds a cell surface bipartite ligand comprising a GDNF family ligand and a GFRα coreceptor, resulting in RET transmembrane signal
Externí odkaz:
https://doaj.org/article/e0fc25a58f5a44f0a8e9b565c5efa8fc
Autor:
Lingtian Zhang, Marialuisa Moccia, David C. Briggs, Jaideep B. Bharate, Naga Rajiv Lakkaniga, Phillip Knowles, Wei Yan, Phuc Tran, Anupreet Kharbanda, Xiuqi Wang, Yuet-Kin Leung, Brendan Frett, Massimo Santoro, Neil Q. McDonald, Francesca Carlomagno, Hong-yu Li
Publikováno v:
Journal of Medicinal Chemistry. 65:1536-1551
Mutations of the rearranged during transfection (RET) kinase are frequently reported in cancer, which make it as an attractive therapeutic target. Herein, we discovered a series of N-trisubstituted pyrimidine derivatives as potent inhibitors for both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de99c59f8ad8a17aa62c446b5f5bf21
https://doi.org/10.1021/acs.jmedchem.1c01280
https://doi.org/10.1021/acs.jmedchem.1c01280
Atypical PKCs are cell polarity kinases that operate at the plasma membrane where they function within multiple molecular complexes to contribute to the establishment and maintenance of polarity. In contrast to the classical and novel PKCs, atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dcc25c99c56933bfed6e899cdc29bd
https://doi.org/10.1101/2023.01.03.522491
https://doi.org/10.1101/2023.01.03.522491
Autor:
Khalil Davis, David J. Mann, Ulrike S. Eggert, John D. Scott, Steven Lynham, Victoria Crossland, Xiaoping Yang, Tanya N. Soliman, Peter J. Parker, Alan Armstrong, Neil Q. McDonald, Lisa Watson, Joanna R. Kelly, Nicola Lockwood
Publikováno v:
Biochemical Journal
A requirement for PKCε in exiting from the Aurora B dependent abscission checkpoint is associated with events at the midbody, however, the recruitment, retention and action of PKCε in this compartment are poorly understood. Here, the prerequisite f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d85219ff82fd92ec0f42d125307988a
http://europepmc.org/articles/PMC8238520
http://europepmc.org/articles/PMC8238520