Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Neil Parrot"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 524-543 (2024)
Abstract Organ‐on‐a‐chip (OoC) systems are a promising new class of in vitro devices that can combine various tissues, cultured in different compartments, linked by media flow. The properties of these novel in vitro systems linked to increased
Externí odkaz:
https://doaj.org/article/416f8c0008364f0abef0e77f37f7a341
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 396-409 (2024)
Abstract Glofitamab is a novel T cell bispecific antibody developed for treatment of relapsed‐refractory diffuse large B cell lymphoma and other non‐Hodgkin's lymphoma indications. By simultaneously binding human CD20‐expressing tumor cells and
Externí odkaz:
https://doaj.org/article/7f592a5758c04aa3a48cc531488fe90e
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 464-475 (2024)
Abstract Antimicrobial resistance increasingly complicates neonatal sepsis in a global context. Fosfomycin and amikacin are two agents being tested in an ongoing multicenter neonatal sepsis trial. Although neonatal pharmacokinetics (PKs) have been de
Externí odkaz:
https://doaj.org/article/c2665b2b937d444095d65ea3327fb1d8
Transplantation in adults with primary hyperoxaluria: Single unit experience and treatment algorithm
Autor:
Ravi Pararajasingam, Titus Augustine, K. Rajendra Prasad, Afshin Tavakoli, Neil Parrot, Hany Riad, Babatunde Campbell, Deep J. Malde
Publikováno v:
Scopus-Elsevier
BACKGROUND Kidney transplantation alone in Primary Hyperoxaluria is associated with a high rate of recurrence and in many cases early graft loss. Liver transplantation offers the possibility of correcting the metabolic defect. MATERIAL/METHODS A retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3179330e363fd4102625cfa88fa07517
https://doi.org/10.12659/aot.882227
https://doi.org/10.12659/aot.882227
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 745-754 (2022)
Abstract Pharmacometrics and the application of population pharmacokinetic (PK) modeling play a crucial role in clinical pharmacology. These methods, which describe data with well‐defined equations and estimate physiologically interpretable paramet
Externí odkaz:
https://doaj.org/article/f9a59e70a44946b89a5679ddb0a995ad
Autor:
Matthias Van der Veken, Michael Aertsen, Joachim Brouwers, Cordula Stillhart, Neil Parrott, Patrick Augustijns
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2323 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/6295215ac27542d389e109030a7546bf
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 191 (2023)
Basmisanil, is a lipophilic drug substance, exhibiting poor solubility and good permeability (BCS class 2). A validated physiologically based biopharmaceutics model (PBBM) has been previously described for tablets dosed in the fed state. The PBBM cap
Externí odkaz:
https://doaj.org/article/7e030cd16a484229b4e9480111e5d294
Autor:
Yuan Chen, Tamara D. Cabalu, Ernesto Callegari, Heidi Einolf, Lichuan Liu, Neil Parrott, Sheila Annie Peters, Edgar Schuck, Pradeep Sharma, Helen Tracey, Vijay V. Upreti, Ming Zheng, Andy Z.X. Zhu, Stephen D. Hall
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 9, Pp 685-695 (2019)
Regulatory agencies currently recommend itraconazole (ITZ) as a strong cytochrome P450 3A (CYP3A) inhibitor for clinical drug–drug interaction (DDI) studies. This work by an International Consortium for Innovation and Quality in Pharmaceutical Deve
Externí odkaz:
https://doaj.org/article/a909582f81534613a6810cda695e685b
Autor:
Matthias Van der Veken, Michael Aertsen, Joachim Brouwers, Cordula Stillhart, Neil Parrott, Patrick Augustijns
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1935 (2022)
The volume and distribution of fluids available in the gastrointestinal (GI) tract may substantially affect oral drug absorption. Magnetic resonance imaging (MRI) has been used in the past to quantify these fluid volumes in adults and its use is now
Externí odkaz:
https://doaj.org/article/19f040f897cc42ddbc8ecd8d4c69e007
Autor:
Allan Valenzuela, Claire Tardiveau, Miriam Ayuso, Laura Buyssens, Chloe Bars, Chris Van Ginneken, Pierluigi Fant, Isabelle Leconte, Annamaria Braendli-Baiocco, Neil Parrott, Georg Schmitt, Yann Tessier, Paul Barrow, Steven Van Cruchten
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1442 (2021)
The adult Göttingen Minipig is an acknowledged model for safety assessment of antisense oligonucleotide (ASO) drugs developed for adult indications. To assess whether the juvenile Göttingen Minipig is also a suitable nonclinical model for pediatric
Externí odkaz:
https://doaj.org/article/305d7cabe6734a7eb7a8899c90c89c5b