Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Neil Osheroff"'
Autor:
Joseph E. Deweese, Neil Osheroff
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13080 (2023)
With the topoisomerase field in its sixth decade [...]
Externí odkaz:
https://doaj.org/article/f58e894cc91f4dc5bb9cc866ecdf06d4
Autor:
Soziema E. Dauda, Jessica A. Collins, Jo Ann W. Byl, Yanran Lu, Jack C. Yalowich, Mark J. Mitton-Fry, Neil Osheroff
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12107 (2023)
Novel bacterial topoisomerase inhibitors (NBTIs) are an emerging class of antibacterials that target gyrase and topoisomerase IV. A hallmark of NBTIs is their ability to induce gyrase/topoisomerase IV-mediated single-stranded DNA breaks and suppress
Externí odkaz:
https://doaj.org/article/57dad8cf2974442080082568e056354a
Autor:
Jeffrey Y. Jian, Neil Osheroff
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11199 (2023)
Type II topoisomerases are essential enzymes that modulate the topological state of DNA supercoiling in all living organisms. These enzymes alter DNA topology by performing double-stranded passage reactions on over- or underwound DNA substrates. This
Externí odkaz:
https://doaj.org/article/4e324df2e8a248a389155c613a119346
Autor:
Eric D. Huseman, Jo Ann W. Byl, Scott M. Chapp, Nathan D. Schley, Neil Osheroff, Steven D. Townsend
Publikováno v:
ACS Central Science, Vol 7, Iss 8, Pp 1327-1337 (2021)
Externí odkaz:
https://doaj.org/article/94bd430164004b28a3afec0b42954363
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 422-436.e5 (2019)
Summary: Termination of DNA replication occurs when two replication forks converge upon the same stretch of DNA. Resolution of topological stress by topoisomerases is crucial for fork convergence in bacteria and viruses, but it is unclear whether sim
Externí odkaz:
https://doaj.org/article/67627de22a2c4fa79af325886887e2a1
Autor:
Katherine L Furniss, Hung-Ji Tsai, Jo Ann W Byl, Andrew B Lane, Amit C Vas, Wei-Shan Hsu, Neil Osheroff, Duncan J Clarke
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003832 (2013)
By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes. In humans, the strand passage reaction of DNA topoisomerase II (Topo II) is the target of s
Externí odkaz:
https://doaj.org/article/925baffde6b44627b6f84bc643f95894
Autor:
Melanie Joannides, Ashley N Mays, Anita R Mistry, Syed Khizer Hasan, Andreas Reiter, Joseph L Wiemels, Carolyn A Felix, Francesco Lo-Coco, Neil Osheroff, Ellen Solomon, David Grimwade
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 3, Iss 1, Pp e2011045-e2011045 (2011)
Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise
Externí odkaz:
https://doaj.org/article/ec9e8c9f53b6491fb0f40175f05e8434
Autor:
Neil Osheroff, Ellen Solomon, Francesco Lo-Coco, Carolyn A Felix, Joseph L Wiemels, Andreas Reiter, Syed Khizer Hasan, Anita R Mistry, Ashley N Mays, Melanie Joannides, David Grimwade
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 3, Iss 1, Pp e2011045-e2011045 (2011)
Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise
Externí odkaz:
https://doaj.org/article/9521ee5ed1a2493180e1845910df1f65
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9994 (2010)
Truncating mutations in the tumor suppressor gene APC (Adenomatous Polyposis Coli) are thought to initiate the majority of colorectal cancers. The 15- and 20-amino acid repeat regions of APC bind beta-catenin and have been widely studied for their ro
Externí odkaz:
https://doaj.org/article/f5eb7ce9673540dea80f330137f9df22
Autor:
Rachael E Hawtin, David E Stockett, Jo Ann W Byl, Robert S McDowell, Tan Nguyen, Michelle R Arkin, Andrew Conroy, Wenjin Yang, Neil Osheroff, Judith A Fox
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10186 (2010)
Topoisomerase II is critical for DNA replication, transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including the anthracyclines and epipodophyllotoxins. However, these drugs are limited by common tumor
Externí odkaz:
https://doaj.org/article/13467f009c0841b5998d831560bc564d