Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Neil O Carragher"'
Publikováno v:
SLAS Discovery, Vol 28, Iss 2, Pp 13-19 (2023)
Three dimensional models of cell culture enables researchers to recreate aspects of tumour biology not replicated by traditional two dimensional techniques. Here we describe a protocol to enable automated high throughput phenotypic profiling across p
Externí odkaz:
https://doaj.org/article/0e5fa7d6e1a84c139b85354a65592b7a
Autor:
Demi Brownlie, Dahlia Doughty-Shenton, Daniel YH Soong, Colin Nixon, Neil O Carragher, Leo M Carlin, Takanori Kitamura
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Metastatic breast cancer is a leading cause of cancer-related death in women worldwide. Infusion of natural killer (NK) cells is an emerging immunotherapy for such malignant tumors, although elimination of the immunosuppressive tumor envir
Externí odkaz:
https://doaj.org/article/0a208b9ae45c43df991c0d62fdbd681b
Autor:
Neil O Carragher, Valerie G Brunton, Alan Serrels, Kurt I Anderson, Marta Canel, Paul Timpson, Ewan J McGhee, Beverley Isherwood
Publikováno v:
Pharmaceutics, Vol 3, Iss 2, Pp 141-170 (2011)
Dynamic regulation of specific molecular processes and cellular phenotypes in live cell systems reveal unique insights into cell fate and drug pharmacology that are not gained from traditional fixed endpoint assays. Recent advances in microscopic ima
Externí odkaz:
https://doaj.org/article/7c3efcd6110642da93527a09028de219
Autor:
Jason T Weiss, Craig eFraser, Belén eRubio-Ruiz, Samuel eMyers, Richard eCrispin, John C Dawson, Valerie G Brunton, E Elizabeth Patton, Neil O Carragher, Asier eUnciti-Broceta
Publikováno v:
Frontiers in Chemistry, Vol 2 (2014)
Palladium-activated prodrug therapy is an experimental therapeutic approach that relies on the unique chemical properties and biocompatibility of heterogeneous palladium catalysis to enable the spatially-controlled in vivo conversion of a biochemical
Externí odkaz:
https://doaj.org/article/25f803213dfa41258b2fc34af2dabfff
Autor:
Neil O Carragher, John C Dawson
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Advances in target-based drug discovery strategies have enabled drug discovery groups in academia and industry to become very effective at generating molecules that are potent and selective against single targets. However, it has become apparent from
Externí odkaz:
https://doaj.org/article/ee588b7b539543cbbb58580a3ee1476c
Autor:
Yakinthi Chrisochoidou, Rajat Roy, Pooyeh Farahmand, Guadalupe Gonzalez, Jennifer Doig, Lukas Krasny, Ella F. Rimmer, Anne E Willis, Marion MacFarlane, Paul H. Huang, Neil O. Carragher, Alison F. Munro, Daniel J. Murphy, Kirill Veselkov, Michael J. Seckl, Miriam F. Moffatt, William O. C. Cookson, Olivier E. Pardo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-20 (2023)
Abstract Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive fibrotic response. The latter is in large part mediated by cancer-associated fibroblasts which mediate tumour progression and poor prognosis. However,
Externí odkaz:
https://doaj.org/article/aaf6d7ac3e1a4d1b86de96ee85ac0b92
Publikováno v:
PLoS ONE, Vol 18, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/0cb6883f0e664add840fa15cef99f256
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
Quantification of YAP localization in esophageal cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeaefc45ec2edeaa334529edbfcd1f4
https://doi.org/10.1158/1535-7163.22506288.v1
https://doi.org/10.1158/1535-7163.22506288.v1
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
We mutated the focal adhesion kinase (FAK) catalytic domain to inhibit binding of the chaperone Cdc37 and ATP, mimicking the actions of a FAK kinase inhibitor. We reexpressed mutant and wild-type FAK in squamous cell carcinoma (SCC) cells from which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d91c39eb635f3918725cf611b30b136
https://doi.org/10.1158/1535-7163.c.6538347
https://doi.org/10.1158/1535-7163.c.6538347
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
FAK kinase-dependent dysregulation of specific FAK-binding proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063d73f411d884de8a2ef1930a7ef1fe
https://doi.org/10.1158/1535-7163.22506285.v1
https://doi.org/10.1158/1535-7163.22506285.v1