Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Neil Maclean"'
Autor:
Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Externí odkaz:
https://doaj.org/article/d082e4930596459b8898e21f8ca1f16d
Autor:
Aaron D. Schimmer, Rashim Pal Singh, Ayesh K. Seneviratne, Geethu E. Thomas, Neil MacLean, Rose Hurren
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100163- (2020)
Summary: We describe a method to silence genes in primary acute myeloid leukemia cells by transducing them with shRNA in lentiviral vectors. The transduction of primary non-adherent cells is particularly challenging. The protocol will aid in performi
Externí odkaz:
https://doaj.org/article/271c6333c8a0432cbe81361b90838f2e
Autor:
Aniket Bankar, Thirushi Piyumika Siriwardena, Biljana Rizoska, Christina Rydergård, Helen Kylefjord, Vilma Rraklli, Anders Eneroth, Pedro Pinho, Stefan Norin, Johan Bylund, Sara Moses, Richard Bethell, Simon Kavanagh, Neil Maclean, Marcela Gronda, Xiaoming Wang, Rose Hurren, Mark D. Minden, Paul Targett-Adams, Aaron D. Schimmer, Mark Albertella
Publikováno v:
Haematologica, Vol 106, Iss 2 (2019)
Externí odkaz:
https://doaj.org/article/e6f9c4496da04b6c9457fce77c3e9d69
Autor:
Dana Yehudai, Sanduni U. Liyanage, Rose Hurren, Biljana Rizoska, Mark Albertella, Marcela Gronda, Danny V Jeyaraju, Xiaoming Wang, Samir H. Barghout, Neil MacLean, Thirushi P. Siriwardena, Yulia Jitkova, Paul Targett-Adams, Aaron D. Schimmer
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia
Externí odkaz:
https://doaj.org/article/a3754aeeba0b4a40bc86a29f3f6df762
Autor:
Lianne E. Rotin, Neil MacLean, Ahmed Aman, Marcela Gronda, Feng-Hsu Lin, Rose Hurren, XiaoMing Wang, Jeffrey L Wrana, Alessandro Datti, Rima Al-awar, Mark D. Minden, Aaron D. Schimmer
Publikováno v:
Haematologica, Vol 101, Iss 11 (2016)
Externí odkaz:
https://doaj.org/article/5cfc0304e17b4b0d81b8ba9f953e109a
Autor:
G Wei Xu, Julia I Toth, Sara R da Silva, Stacey-Lynn Paiva, Julie L Lukkarila, Rose Hurren, Neil Maclean, Mahadeo A Sukhai, Rabindra N Bhattacharjee, Carolyn A Goard, Bruno Medeiros, Patrick T Gunning, Sirano Dhe-Paganon, Matthew D Petroski, Aaron D Schimmer
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93530 (2014)
The NEDD8-activating enzyme (NAE) initiates neddylation, the cascade of post-translational NEDD8 conjugation onto target proteins. MLN4924, a selective NAE inhibitor, has displayed preclinical anti-tumor activity in vitro and in vivo, and promising c
Externí odkaz:
https://doaj.org/article/c25a0099eda545d9907d3b27a9070b27
Autor:
Tyler J W Robinson, Jeff C Liu, Frederick Vizeacoumar, Thomas Sun, Neil Maclean, Sean E Egan, Aaron D Schimmer, Alessandro Datti, Eldad Zacksenhaus
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78641 (2013)
Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available. The retinoblastoma (RB1) tumor suppressor is frequently lost in human TNBC. Knockdown of RB1
Externí odkaz:
https://doaj.org/article/cf5d10504ba3454fa43bda899d685d0f
Autor:
Reza Beheshti Zavareh, Mahadeo A Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Craig D Simpson, Neil Maclean, Francis Zih, Troy Ketela, Carol J Swallow, Jason Moffat, David R Rose, Harry Schachter, Aaron D Schimmer, James W Dennis
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43721 (2012)
Oncogenic signaling promotes tumor invasion and metastasis, in part, by increasing the expression of tri- and tetra- branched N-glycans. The branched N-glycans bind to galectins forming a multivalent lattice that enhances cell surface residency of gr
Externí odkaz:
https://doaj.org/article/76ee1fcc2d2a4fbda66813266fae872d
Autor:
Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Parasvi S. Patel, Fieke W. Hoff, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim P. Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razq Hakem, Steve Kornblau, John E. Dick, Aaron D. Schimmer
Publikováno v:
Nature Cell Biology, 24(6), 872-884. Nature Publishing Group
Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.M
Autor:
Aaron D. Schimmer, Robert A. Batey, Mark D. Minden, Jason Moffat, John C. Reed, Troy Ketela, Neil MacLean, Yanina Eberhard, Marcela Gronda, Fernando Suarez Saiz, Xinliang Mao, Kika Anyiwe, Rose Hurren, Mahadeo A. Sukhai, Craig D. Simpson, Shadi Dalili, Tabitha E. Wood
Supplementary Figure Legends 1-4 from Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3fa615ac90b1666eeb0a32abff18e8
https://doi.org/10.1158/1535-7163.22484898
https://doi.org/10.1158/1535-7163.22484898