Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Neil M. Kernohan"'
Autor:
Wael Ageeli, Xinyu Zhang, Chidozie N. Ogbonnaya, Susan E. Bray, Neil M. Kernohan, Jennifer Wilson, Chunhui Li, Ghulam Nabi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionGrowing evidence suggests that the tumor microenvironment (TME) represented by cellular and acellular components plays a key role in the multistep process of metastases and response to therapies. However, imaging and molecular characteriz
Externí odkaz:
https://doaj.org/article/1231c242dea64a63a55573f58cf5fa3b
Autor:
Lyssa T. Gold, Susan E. Bray, Neil M. Kernohan, Nina Henderson, Maisie Nowicki, Glenn R. Masson
BackgroundMalignant mesothelioma is a tumour that is strongly associated with a history of asbestos exposure and which derives from mesothelial cells that line the serous cavities of the body. The tumour most commonly arises in the pleural cavity, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d6770720c69190ea5bf3938355d153
https://doi.org/10.1101/2023.03.24.23287516
https://doi.org/10.1101/2023.03.24.23287516
Publikováno v:
JAMA Oncology. 5:565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5344a4e7a873d88a2b16167ef4ffbda
https://doi.org/10.1001/jamaoncol.2018.5317
https://doi.org/10.1001/jamaoncol.2018.5317
Autor:
Sudhir Tauro, Neil M. Kernohan, Josh T. Coats, John R. Goodlad, Alasdair D R Mackie, Prasad Guntur Ramkumar, Lesley M McMahon
Publikováno v:
Lancet (London, England). 388(10049)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f40a8e092fdbbd3016b437ca4483be3
https://pubmed.ncbi.nlm.nih.gov/27628521
https://pubmed.ncbi.nlm.nih.gov/27628521
Autor:
Susan E. Bray, Neil M. Kernohan, Philip J. Coates, Dario R. Alessi, M. V.C.L. Appleyard, Stewart Fleming, Karen Murray, Stephan Wullschleger, Alastair M. Thompson
Publikováno v:
British Journal of Cancer
Background: Observations that diabetics treated with biguanide drugs have a reduced risk of developing cancer have prompted an enthusiasm for these agents as anti-cancer therapies. We sought to determine the efficacy of the biguanide phenformin in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad995d3e2947443859c49e2fa840c76
http://europepmc.org/articles/PMC3304424
http://europepmc.org/articles/PMC3304424
Autor:
D M Milne, C. Hogan, Caroline Hutchison, David W. Meek, John R. Goodlad, Mark K. Saville, Neil M. Kernohan, Lynnette Marcar
Publikováno v:
Journal of Biological Chemistry. 283:18012-18023
Mutation of the p53 gene is a common event during tumor pathogenesis. Other mechanisms, such as mdm2 amplification, provide alternative routes through which dysfunction of the p53 pathway is promoted. Here, we address the hypothesis that elevated exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34a7fccaf7a77c2aa8bdf7e83e5d1b0
https://doi.org/10.1074/jbc.m709695200
https://doi.org/10.1074/jbc.m709695200
Autor:
F M Muller, Neil M. Kernohan, S Morley, S Lewis-Jones, Alan Evans, John R. Goodlad, David Meiklejohn
Publikováno v:
British Journal of Dermatology. 157:426-429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f893f61b2566d64de49e6d20fcd87a22
https://doi.org/10.1111/j.1365-2133.2007.08038.x
https://doi.org/10.1111/j.1365-2133.2007.08038.x
Autor:
Rudolf Nenutil, Ted R. Hupp, Mairi J. Hunter, Joanne Darragh, Peter E. Ross, John F. Dillon, Neil M. Kernohan, Elizabeth Pohler, Lenny Nelson, Borek Vojtesek
Publikováno v:
FEBS Journal. 273:1930-1947
Stress protein responses have evolved in part as a mechanism to protect cells from the toxic effects of environmental damaging agents. Oesophageal squamous epithelial cells have evolved an atypical stress response that results in the synthesis of a 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::018e53edae345597bb0d61e3d63c297b
https://doi.org/10.1111/j.1742-4658.2006.05206.x
https://doi.org/10.1111/j.1742-4658.2006.05206.x
Publikováno v:
British Journal of Dermatology. 152:1001-1008
Summary Background High-dose ultraviolet (UV) A1 therapy (doses in the order of 130 J cm−2) is effective for atopic dermatitis and scleroderma. UVA1 has been shown to induce a dose-dependent increase in p53 expression in keratinocytes. Objectives T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d9bd6ffde32b84614c5f3c6715876c
https://doi.org/10.1111/j.1365-2133.2005.06557.x
https://doi.org/10.1111/j.1365-2133.2005.06557.x
Autor:
Neil M. Kernohan, Mary O’Neill, Susan E. Bray, Jian Zhang, Virginia Appleyard, Karen Murray, Alastair M. Thompson, George Thomson, James Varani
Publikováno v:
Anti-Cancer Drugs. 15:991-996
The efficacy of MDI-301, a non-toxic novel synthetic retinoid, was found to be equivalent to the natural 9-cis-retinoic acid (RA) in vitro against estrogen-dependent MCF7 and T47D breast cancer cell lines which express RA receptor (RAR) alpha. Both r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4397f4f4ecfe618248e90517a9f936c6
https://doi.org/10.1097/00001813-200411000-00009
https://doi.org/10.1097/00001813-200411000-00009