Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Neil M O'Brien-Simpson"'
Autor:
Vladimir Ilievski, Paulina K Zuchowska, Stefan J Green, Peter T Toth, Michael E Ragozzino, Khuong Le, Haider W Aljewari, Neil M O'Brien-Simpson, Eric C Reynolds, Keiko Watanabe
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204941 (2018)
BACKGROUND:The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further, studies using animal model of periodontitis and human post-mortem
Externí odkaz:
https://doaj.org/article/650fd6abc97a4646873b3a984429bcd0
Autor:
Tamara Matthyssen, Wenyi Li, James A. Holden, Jason C. Lenzo, Sara Hadjigol, Neil M. O’Brien-Simpson
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionMelittin is a potent antimicrobial peptide from bee venom that is effective against both Gram-positive and Gram-negative bacteria. However, it is extremely toxic to mammalian cells and, as yet, has no clinical use. Modifications to its am
Externí odkaz:
https://doaj.org/article/81af5452720b48978a8b1731c22bac4e
Autor:
Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Yu-Yen Chen, William Singleton, Katelyn T Gause, Yan Yan, Frank Caruso, Eric C Reynolds
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0151967 (2016)
Highly purified outer membrane vesicles (OMVs) of the periodontal pathogens, Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia were produced using tangential flow ultrafiltration, ultracentrifugation and Optiprep density gradient
Externí odkaz:
https://doaj.org/article/dca2c5983f8449e5853555e93e330330
Autor:
Roselind S Lam, Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Shao B Fong, Eric C Reynolds
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158629 (2016)
Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Tissue macrophages are amongst the first immune cells to respond to bacteria and depending on the cytokine profile at the infection site, macrophages are pri
Externí odkaz:
https://doaj.org/article/d720ce551abc4d8285e85e1500415c11
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151694 (2016)
We describe a microbial flow cytometry method that quantifies within 3 hours antimicrobial peptide (AMP) activity, termed Minimum Membrane Disruptive Concentration (MDC). Increasing peptide concentration positively correlates with the extent of bacte
Externí odkaz:
https://doaj.org/article/38d3647f4a924794a6a2679bef642af7
Autor:
Tetiana Hourani, Alexis Perez-Gonzalez, Khashayar Khoshmanesh, Rodney Luwor, Adrian A. Achuthan, Sara Baratchi, Neil M. O’Brien-Simpson, Akram Al-Hourani
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Macrophages are heterogeneous innate immune cells that are functionally shaped by their surrounding microenvironment. Diverse macrophage populations have multifaceted differences related to their morphology, metabolism, expressed markers, an
Externí odkaz:
https://doaj.org/article/aabdd5ccbaab4a468773259c96fcc933
Autor:
Bruce Lin, Andrew Hung, William Singleton, Kevion K. Darmawan, Rachael Moses, Bicheng Yao, Hongkang Wu, Anders Barlow, Marc‐Antoine Sani, Alastair J. Sloan, Mohammed Akhter Hossain, John D. Wade, Yuning Hong, Neil M. O'Brien‐Simpson, Wenyi Li
Publikováno v:
Aggregate, Vol 4, Iss 4, Pp n/a-n/a (2023)
Abstract Antimicrobial peptides (AMPs) are potentially powerful alternatives to conventional antibiotics in combating multidrug resistance, given their broad spectrum of activity. They mainly interact with cell membranes through surface electrostatic
Externí odkaz:
https://doaj.org/article/f6f052e528584d6eabb539cbf923298f
Publikováno v:
Aggregate, Vol 4, Iss 3, Pp n/a-n/a (2023)
Abstract Dental implants are the most common therapeutic approach for resolving tooth loss and damage. Despite technical advances in treatment, implant failure rates can be as high as 23% with the major cause of peri‐implantitis: a multi‐species
Externí odkaz:
https://doaj.org/article/2af781aaadb84830a416a52f662eedf6
Autor:
Nidhish Francis, Reza Sanaei, Babatunde A. Ayodele, Neil M. O'Brien‐Simpson, David P. Fairlie, Lakshmi C. Wijeyewickrema, Robert N. Pike, Eleanor Jean Mackie, Charles Neil Pagel
Publikováno v:
Journal of Periodontal Research. 58:544-552
Autor:
Tao Huang, Xin Li, Michael Maier, Neil M. O'Brien-Simpson, Daniel E. Heath, Andrea J. O'Connor
Publikováno v:
Acta Biomaterialia. 158:56-79