Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Neil Kubica"'
Supplementary Figure 1 from Reduced Eukaryotic Initiation Factor 2Bε-Subunit Expression Suppresses the Transformed Phenotype of Cells Overexpressing the Protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192612f517d13445e856dd69437f840e
https://doi.org/10.1158/0008-5472.22376348.v1
https://doi.org/10.1158/0008-5472.22376348.v1
Eukaryotic initiation factor 2B (eIF2B), a five-subunit guanine nucleotide exchange factor, plays a key role in the regulation of mRNA translation. Expression of its ε-subunit is specifically up-regulated in certain conditions associated with increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baf35516ebaacc6f34e8ee3820d3707
https://doi.org/10.1158/0008-5472.c.6498167
https://doi.org/10.1158/0008-5472.c.6498167
Supplementary Figure Legend from Reduced Eukaryotic Initiation Factor 2Bε-Subunit Expression Suppresses the Transformed Phenotype of Cells Overexpressing the Protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dc47850a4d2d6c49670e3dca9d9ee3
https://doi.org/10.1158/0008-5472.22376345.v1
https://doi.org/10.1158/0008-5472.22376345.v1
Autor:
Ashley Maillet, Fei Liu, Chao Fang, Jinxing Li, Neil Kubica, Lars Kolster Petersen, Donovan N. Chin, Nils Jakob Vest Hansen, Luis A. Barrera, Jenifer B Kaplan, Herschel Mukherjee, Gnanasambandam Kumaravel, J Craig Blain, Lee E Vandivier, Jessica E. Friedman, Allan Beck Christensen, David M. Chenoweth, Jennifer C. Petter
Publikováno v:
ACS Chemical Biology. 15:2374-2381
RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small molecules, however, has been hampered by the relative lack of methods for the analysis of small molecule-RNA interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7520d11f7303715e89e8764fd08c5649
https://doi.org/10.1021/acschembio.0c00357
https://doi.org/10.1021/acschembio.0c00357
Autor:
Greggory M. Rice, Anthony M. Mustoe, Christine E. Hajdin, Jeremy Baryza, Kevin M. Weeks, Brant K. Peterson, Vera M. Ruda, Steven Busan, Neil Kubica, Razvan Nutiu
Messenger RNAs (mRNAs) can fold into complex structures that regulate gene expression. Resolving such structures de novo has remained challenging and has limited understanding of the prevalence and functions of mRNA structure. We use SHAPE-MaP experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967272188c82a83ea9166b362bee2442
https://europepmc.org/articles/PMC5866243/
https://europepmc.org/articles/PMC5866243/
Autor:
Lewis C. Cantley, Neil Kubica, Steven P. Gygi, Sang-Oh Yoon, Xiaoju Max Ma, Gregory R. Hoffman, John Blenis, Judit Villén, Yonghao Yu, George Poulogiannis, Qian Yang
Publikováno v:
Science. 332:1322-1326
The evolutionarily conserved serine-threonine kinase mammalian target of rapamycin (mTOR) plays a critical role in regulating many pathophysiological processes. Functional characterization of the mTOR signaling pathways, however, has been hampered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16fee53ddae53fa1683fca5408824225
https://doi.org/10.1126/science.1199484
https://doi.org/10.1126/science.1199484
Publikováno v:
The Journal of Physiology. 573:497-510
The present study examined the effects of an acute bout of treadmill exercise on signalling through the extracellular signal-regulated kinase (ERK)1/2 and mammalian target of rapamycin (mTOR) pathways to regulatory mechanisms involved in mRNA transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732a2ed266ca70b4e914378eaec44ee2
https://doi.org/10.1113/jphysiol.2005.103481
https://doi.org/10.1113/jphysiol.2005.103481
Publikováno v:
Journal of Applied Physiology. 96:679-687
The focus of the study described herein was to examine the relative expression levels of mRNAs and proteins relevant to the regulation of translational initation, and hence protein synthesis, in the time course after an acute bout of resistance exerc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f3a01e5afa309c94a1612946215b4a
https://doi.org/10.1152/japplphysiol.00962.2003
https://doi.org/10.1152/japplphysiol.00962.2003
Autor:
John Blenis, Neil Kubica
Publikováno v:
mTOR Pathway and mTOR Inhibitors in Cancer Therapy ISBN: 9781603272704
The mammalian target of rapamycin (mTOR) is an atypical serine/threonine kinase that plays an indispensable role in the control of cell growth. When localized with the interacting proteins raptor and mLST8 in the mammalian target of rapamycin complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0389d3cf4e9121bf237af0f743d58f7b
https://doi.org/10.1007/978-1-60327-271-1_1
https://doi.org/10.1007/978-1-60327-271-1_1
Publikováno v:
Cancer research. 68(21)
Eukaryotic initiation factor 2B (eIF2B), a five-subunit guanine nucleotide exchange factor, plays a key role in the regulation of mRNA translation. Expression of its ε-subunit is specifically up-regulated in certain conditions associated with increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad0b01054915ca84c16bc194c320bd5
https://pubmed.ncbi.nlm.nih.gov/18974117
https://pubmed.ncbi.nlm.nih.gov/18974117