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pro vyhledávání: '"Neil K. O'Connor"'
Autor:
Alex S. Hudson, Steven L. Cobb, Cormac D. Murphy, Neil K. O’Connor, Vanessa Duncan, Jennifer C Robertson, Deborah O’Neil
Publikováno v:
Amino acids, 2014, Vol.46(12), pp.2745-2752 [Peer Reviewed Journal]
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While attempting to improve production of fluoro-iturin A in Bacillus sp. CS93 new mono- and di-fluorinated fengycins were detected in culture supernatants by 19F NMR and tandem mass spectrometry, after incubation of the bacterium with 3-fluoro-l-tyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c88d0b408b995f63e00d449f578a881
http://dro.dur.ac.uk/25596/1/25596.pdf
http://dro.dur.ac.uk/25596/1/25596.pdf
Autor:
Emma L Kavanagh, Michael Winn, Neil K. O’Connor, Cliona Nic Gabhann, Cormac D. Murphy, Petr Beier
We report, for the first time, the biotransformation of potential pollutants bearing the pentafluorosulfanyl (SF5-) functional group in a fungus and bacteria. Cunninghamella elegans transformed p-methoxy phenyl SF5 via demethylation; Pseudomonas knac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f659396ee5daba65f312c2382871ae7b
Autor:
Graham Sandford, Neil K. O’Connor, Victoria L. Elder, Cormac D. Murphy, Tara V. Bright, Fay Dalton
Publikováno v:
Organic & biomolecular chemistry, 2013, Vol.11(7), pp.1135-1142 [Peer Reviewed Journal]
A significant proportion of pharmaceuticals are fluorinated and selecting the site of fluorine incorporation can be an important beneficial part a drug development process. Here we describe initial experiments aimed at the development of a general me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bd98a28b267661b047e1401e714016
https://pubmed.ncbi.nlm.nih.gov/23299916
https://pubmed.ncbi.nlm.nih.gov/23299916
Incorporation of fluorine into antibiotics can moderate their biological activity, lipophilicity and metabolic stability. The introduction of fluorine into an antimicrobial lipopeptide produced by Bacillus sp. CS93 via precursor-directed biosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f97e4e744d779e6608ac20063b8bee8