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of 83
pro vyhledávání: '"Neil K. Gibbs"'
A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues
Autor:
Sarah A. Hibbert, Rachel E.B. Watson, Neil K. Gibbs, Patrick Costello, Clair Baldock, Anthony S. Weiss, Christopher E.M. Griffiths, Michael J. Sherratt
Publikováno v:
Redox Biology, Vol 5, Iss , Pp 101-113 (2015)
Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration,
Externí odkaz:
https://doaj.org/article/5a7c4ff956604567b22d9610d0628bcc
Autor:
Neil K. Gibbs
Publikováno v:
The Journal of Nutrition. 150:2576S-2579S
Atopic dermatitis (AD) is an incurable, inflammatory skin condition that is prevalent (∼20%) in young children. There is an unmet clinical need, particularly in children, for safe interventions that target the etiology of the disease. Deficiencies
Publikováno v:
Tan, S P, Brown, S B, Griffiths, C E, Weller, R B & Gibbs, N K 2017, ' Feeding filaggrin : effects of l-histidine supplementation in atopic dermatitis ', Clinical, Cosmetic and Investigational Dermatology, vol. 10, pp. 403-411 . https://doi.org/10.2147/CCID.S146760
Clinical, Cosmetic and Investigational Dermatology
Tan, S P, Brown, S B, Griffiths, C E M, Weller, R B & Gibbs, N K 2017, ' Feeding filaggrin : Effects of l-histidine supplementation in atopic dermatitis ', Clinical, Cosmetic and Investigational Dermatology, vol. 10, pp. 403-411 . https://doi.org/10.2147/CCID.S146760, https://doi.org/10.2147/CCID.S146760
Clinical, Cosmetic and Investigational Dermatology
Tan, S P, Brown, S B, Griffiths, C E M, Weller, R B & Gibbs, N K 2017, ' Feeding filaggrin : Effects of l-histidine supplementation in atopic dermatitis ', Clinical, Cosmetic and Investigational Dermatology, vol. 10, pp. 403-411 . https://doi.org/10.2147/CCID.S146760, https://doi.org/10.2147/CCID.S146760
Siao Pei Tan,1,2 Simon B Brown,1,2 Christopher EM Griffiths,3 Richard B Weller,1,2 Neil K Gibbs3,4 1MRC Centre for Inflammation Research, 2Department of Dermatology, The University of Edinburgh, Edinburgh, 3Dermatology Centre, Division of Musculoskel
Autor:
Suzanne M. Pilkington, Peter S. Friedmann, Neil K. Gibbs, Lesley E. Rhodes, Karen A. Massey, Anna Nicolaou, S Bennett, Patrick Costello
Publikováno v:
Pilkington, S, Gibbs, N, Costello, P, Bennett, S, Massey, K A, Friedmann, P S, Nicolaou, A & Rhodes, L 2016, ' Effect of oral eicosapentaenoic acid on epidermal Langerhans cell numbers and PGD2 production in UVR-exposed human skin: a randomised controlled study ', Experimental Dermatology . https://doi.org/10.1111/exd.13177
Langerhans cells (LCs) are sentinels of skin's immune system, their loss from epidermis contributing to UVR suppression of cell-mediated immunity (CMI). Omega-3 polyunsaturated fatty acids show potential to reduce UVR suppression of CMI in mice and h
Autor:
Neil K. Gibbs, Rachel E.B. Watson, Christopher E.M. Griffiths, Sarah A. Hibbert, Michael J. Sherratt
Publikováno v:
Hibbert, S, Watson, R, Griffiths, C, Gibbs, N & Sherratt, M 2019, ' Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins ', Cell Signal, vol. 54, pp. 191-199 . https://doi.org/10.1016/j.cellsig.2018.11.024
Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f34e84c80fdbdb67169eb6e318d0dc
https://linkinghub.elsevier.com/retrieve/pii/S0898656818303024
https://linkinghub.elsevier.com/retrieve/pii/S0898656818303024
A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues
Autor:
Rachel E.B. Watson, Sarah A. Hibbert, Christopher E.M. Griffiths, Neil K. Gibbs, Anthony S. Weiss, Patrick Costello, Clair Baldock, Michael J. Sherratt
Publikováno v:
Redox Biology, Vol 5, Iss, Pp 101-113 (2015)
Redox Biology
Redox Biology
Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration,
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 30:112-127
Skin cancer is a major public health concern, and the primary aetiological factor in the majority of skin cancers is ultraviolet radiation (UVR) exposure. UVR not only induces potentially mutagenic DNA damage but also suppresses cell-mediated immunit
Autor:
Neil K. Gibbs, Mary Norval
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 29:57-64
Exposure to ultraviolet radiation can lead to suppression of many adaptive immune responses, both to antigens encountered within a short period of the irradiation (primary) and to antigens previously encountered (memory). The pathways involved are co
Autor:
Joachim Kreysa, Mara Ceridono, Eckhard Heisler, Valérie Zuang, João Barroso, Anthony M. Lynch, Mick D. Fellows, David Jones, Catherine Robles, J. Frank Nash, Jacqueline K Akunda, Neil K. Gibbs, Peter Kasper, Cyrille Krul, Abigail Jacobs, Hans Werner Vohr, Dagmar Jírová, Helena Kandarova, Kazuichi Nakamura, Douglas C. Bauer, Nathalie Alépée, Femke M. van de Water, Uwe Pfannenbecker, Olivier Wattrelos, Ann De Smedt, Wolfgang Muster, Gareth Phillips, Douglas B. Learn, Vera Rogiers, Ulla Wändel Liminga, Julie A. Woods, Raffaella Corvi, Manfred Liebsch, Phil Wilcox, Pär Tellner
Publikováno v:
Regulatory Toxicology and Pharmacology, June, 3, 63, 480-488
This is the report from the “ECVAM–EFPIA workshop on 3T3 NRU Phototoxicity Test: Practical Experience and Implications for Phototoxicity Testing”, jointly organized by ECVAM and EFPIA and held on the 25–27 October 2010 in Somma Lombardo, Ital
Low-dose ultraviolet radiation selectively degrades chromophore-rich extracellular matrix components
Autor:
Siobhan M Reilly, Michael J. Sherratt, Rachel E.B. Watson, Neil K. Gibbs, Christopher P Bayley, Christopher E.M. Griffiths
Publikováno v:
The Journal of Pathology. 222:32-40
Photoageing of human skin due to chronic exposure to ultraviolet radiation (UVR) is characterized histologically by extensive remodelling of the dermal elastic fibre system. Whilst enzymatic pathways are thought to play a major role in mediating extr