Elucidating the molecular programming of a nonlinear non-ribosomal peptide synthetase responsible for fungal siderophore biosynthesis

Autor: Matthew Jenner, Yang Hai, Hong H. Nguyen, Munro Passmore, Will Skyrud, Junyong Kim, Neil K. Garg, Wenjun Zhang, Rachel R. Ogorzalek Loo, Yi Tang

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Siderophores belonging to the ferrichrome family are essential for the viability of fungal species and play a key role for virulence of numerous pathogenic fungi. Despite their biological significance, our understanding of how these iron-che

Externí odkaz: https://doaj.org/article/55fce6b1e0a0485a86f2208747b053b0

Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds

Autor: Sarah M. Anthony, Laura G. Wonilowicz, Matthew S. McVeigh, Neil K. Garg

Publikováno v: JACS Au, Vol 1, Iss 7, Pp 897-912 (2021)

Externí odkaz: https://doaj.org/article/7764778acc04475dbfefaedfd3ba21ff

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Autor: Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullie, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey R.J. Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, Jason M. Rohde

Publikováno v: ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)

Externí odkaz: https://doaj.org/article/9f2975f36dd648f0b92b6e0f2b27c087

Total synthesis of lissodendoric acid A via stereospecific trapping of a strained cyclic allene

Autor: Francesca M. Ippoliti, Nathan J. Adamson, Laura G. Wonilowicz, Daniel J. Nasrallah, Evan R. Darzi, Joyann S. Donaldson, Neil K. Garg

Publikováno v: Science. 379:261-265

Small rings that contain allenes are unconventional transient compounds that have been known since the 1960s. Despite being discovered around the same time as benzyne and offering a number of synthetically advantageous features, strained cyclic allen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e7f77230d1f8b574f01feccede5ea0b
https://doi.org/10.1126/science.ade0032

Merging Metals and Strained Intermediates

Autor: Katie A. Spence, Arismel Tena Meza, Neil K. Garg

Publikováno v: Chem catalysis. 2(8)

Strained intermediates such as cyclic alkynes and allenes are most commonly utilized in nucleophilic additions and cycloadditions, but have seen increased use in a third area of reactivity: metal-mediated transformations. The merger of strained inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e755a364d329c2b9f0958139b3908a9
https://pubmed.ncbi.nlm.nih.gov/36386492