Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Neil J. Kelly"'
Autor:
Neil J. Kelly, David Newhouse, Himal Chapagain, Ashish Patel, Yicheng Tang, Ato Howard, Anna Kirillova, Hee‐Jung J. Kim, Haris Rahman, Wadih El Khoury, Seyed Mehdi Nouraie, Gavin Hickey, Leyla Elif Sade, Sandeep Jain, Stephen Y. Chan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 23 (2023)
Background Left heart disease is the most common cause of pulmonary hypertension (PH) and is frequently accompanied by increases in pulmonary vascular resistance. However, the distinction between phenotypes of PH due to left heart disease with a norm
Externí odkaz:
https://doaj.org/article/a4fced695e4c486aaf6fe8ebe1aa57df
Autor:
Neha Hafeez, Anna Kirillova, Yunshan Yue, Rashmi J. Rao, Neil J. Kelly, Wadih El Khoury, Yassmin Al Aaraj, Yi‐Yin Tai, Adam Handen, Ying Tang, Danli Jiang, Ting Wu, Yingze Zhang, Dennis McNamara, Tatiana V. Kudryashova, Elena A. Goncharova, Dmitry Goncharov, Thomas Bertero, Mehdi Nouraie, Gang Li, Wei Sun, Stephen Y. Chan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 7 (2023)
Background Pulmonary arterial hypertension (PAH) is a complex, fatal disease where disease severity has been associated with the single nucleotide polymorphism (SNP) rs2856830, located near the human leukocyte antigen DPA1 (HLA‐DPA1) gene. We aimed
Externí odkaz:
https://doaj.org/article/9664f574fd8840f292c4a425b64c4fd2
Autor:
Neil J. Kelly, Stephen Y. Chan
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 23, Iss 11, p 378 (2022)
Pulmonary arterial hypertension (PAH) is an enigmatic and deadly vascular disease with no known cure. Recent years have seen rapid advances in our understanding of the molecular underpinnings of PAH, with an expanding knowledge of the molecular, cell
Externí odkaz:
https://doaj.org/article/a3964614d15e4e61bcbbad341f9918d8
Autor:
John Sembrat, Seyed Mehdi Nouraie, Bryan J. McVerry, Jeremy A. Mazurek, Neil J. Kelly, Sathish Badu Vasamsetti, Dennis M. McNamara, Yassmin Al Aaraj, Partha Dutta, Anjali Vaidya, Frank C. Sciurba, Yi-Yin Tai, Yuchi Han, Zeyu Xiong, Mauricio Rojas, Makenna E. Romanelli, Janet S. Lee, Annie M. Watson, Yingze Zhang, Marc A. Simon, Charles F. McTiernan, Adam Handen, Kerri Akaya Smith, Wei Sun, Jingsi Zhao, Stephen Y. Chan, Gil Speyer, Ying Tang, Seungchan Kim
Publikováno v:
JACC: Basic to Translational Science. 5:1073-1092
Utilizing publicly available ribonucleic acid sequencing data, we identified SCUBE1 as a BMPR2-related gene differentially expressed between induced pluripotent stem cell-endothelial cells derived from pulmonary arterial hypertension (PAH) patients c
Autor:
Stephen Y. Chan, Neil J. Kelly
Publikováno v:
Reviews in Cardiovascular Medicine. 23:378
Autor:
John Sembrat, Marc A. Simon, Charles F. McTiernan, Partha Dutta, Wei Sun, Yuchi Han, Gil Speyer, Mehdi Nouraie, Mauricio Rojas, Adam Handen, Yingze Zhang, Frank C. Sciurba, Bryan J. McVerry, Ying Tang, Zeyu Xiong, Makenna E. Romanelli, Neil J. Kelly, Annie M. Watson, Yassmin Al Aaraj, Sathish Babu Vasamsetti, A. Smith, Seungchan Kim, Janet S. Lee, Dennis M. McNamara, Jeremy A. Mazurek, Yi-Yin Tai, Anjali Vaidya, Jingsi Zhao, Stephen Y. Chan
Publikováno v:
Circulation. 142
Introduction: Pulmonary arterial hypertension (PAH) is a morbid vascular disease where mutations of bone morphogenetic protein receptor 2 (BMPR2) control pulmonary endothelial pathophenotypes. Transcriptomic screening from endothelial cells (ECs) der
Autor:
Neil J. Kelly, Alyssa D. Gregory, Josiah E. Radder, Steven D. Shapiro, Naftali Kaminski, Frank C. Sciurba, Joseph K. Leader, Yingze Zhang, Shibing Yu
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 196:159-171
Rationale: Genetic association studies in chronic obstructive pulmonary disease have primarily tested for association with common variants, the results of which explain only a portion of disease heritability. Because rare variation is also likely to
Autor:
Marta Bueno, Elena A. Goncharova, Jeffrey J. Baust, Dmitry A. Goncharov, Mark T. Gladwin, Timothy N. Bachman, Rebecca Vanderpool, Yen-Chun Lai, Ana L. Mora, Josiah E. Radder, Neil J. Kelly, Jian Hu, Steven D. Shapiro, Alison Morris, Qingqing Meng
Publikováno v:
American journal of respiratory cell and molecular biology, vol 56, iss 4
Pulmonary hypertension (PH) associated with heart failure with preserved ejection fraction (PH-HFpEF; World Health Organization Group II) secondary to left ventricular (LV) diastolic dysfunction is the most frequent cause of PH. It is an increasingly
Autor:
Josiah E. Radder, Michael H. Cho, Alyssa D. Gregory, Yingze Zhang, Edwin K. Silverman, Annerose Berndt, Steven D. Shapiro, Amund Gulsvik, Yanxia Chu, David Sparrow, James D. Crapo, Terri H. Beaty, Neil J. Kelly, Adriana S. Leme, Per Bakke, Augusto A. Litonjua
Publikováno v:
American journal of respiratory cell and molecular biology. 57(3)
Chronic obstructive pulmonary disease (COPD) is caused by a complex interaction of environmental exposures, most commonly cigarette smoke, and genetic factors. Chronic cigarette smoke exposure in the mouse is a commonly used animal model of COPD. We
Autor:
Nadine Dandachi, Christine L. Burton, Adriana S. Leme, Alyssa D. Gregory, Josiah E. Radder, Mark T. Gladwin, Ana L. Mora, Yen-Chun Lai, Jeffrey J. Baust, Brittani A. Agostini, Timothy N. Bachman, Neil J. Kelly, John P. Wood, Rebecca Vanderpool, Steven D. Shapiro, Karin Potoka, Alison Morris
Pulmonary hypertension (PH) is associated with features of obesity and metabolic syndrome that translate to the induction of PH by chronic high-fat diet (HFD) in some inbred mouse strains. We conducted a genome-wide association study (GWAS) to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f528f7f4deb8888cdc720f7eb21c7f89
https://europepmc.org/articles/PMC5449510/
https://europepmc.org/articles/PMC5449510/