Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19

Autor: Ghulam Mustafa, Prajwal P. Nandekar, Neil J. Bruce, Rebecca C. Wade

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 18, p 4328 (2019)

The human cytochrome P450 (CYP) 2C9 and 2C19 enzymes are two highly similar isoforms with key roles in drug metabolism. They are anchored to the endoplasmic reticulum membrane by their N-terminal transmembrane helix and interactions of their cytoplas

Externí odkaz: https://doaj.org/article/c10f8c49592e46ce8e92766915999e25

Influence of Transmembrane Helix Mutations on Cytochrome P450-Membrane Interactions and Function

Autor: Rebecca C. Wade, Tyler Camp, Prajwal P. Nandekar, Neil J. Bruce, Ghulam Mustafa, Michael C. Gregory, Stephen G. Sligar

Publikováno v: Biophysical Journal

Human cytochrome P450 (CYP) enzymes play an important role in the metabolism of drugs, steroids, fatty acids, and xenobiotics. Microsomal CYPs are anchored in the endoplasmic reticulum membrane by an N-terminal transmembrane (TM) helix that is connec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0ef41f66ae5283732109357d5f705a
http://europepmc.org/articles/PMC6369400

Brownian Dynamics Simulations of Proteins in the Presence of Surfaces: Long-range Electrostatics and Mean-field Hydrodynamics

Autor: Daria B. Kokh, Neil J. Bruce, Rebecca C. Wade, Martin Reinhardt

Publikováno v: Journal of Chemical Theory and Computation, Vol. 17, No. 6

Simulations of macromolecular diffusion and adsorption in confined environments can offer valuable mechanistic insights into numerous biophysical processes. In order to model solutes at atomic detail on relevant time scales, Brownian dynamics simulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6dc52b93b76ea3041f2db0598fb403
http://arxiv.org/abs/2012.09248

Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19

Autor: Rebecca C. Wade, Prajwal P. Nandekar, Neil J. Bruce, Ghulam Mustafa

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4328 (2019)

The human cytochrome P450 (CYP) 2C9 and 2C19 enzymes are two highly similar isoforms with key roles in drug metabolism. They are anchored to the endoplasmic reticulum membrane by their N-terminal transmembrane helix and interactions of their cytoplas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9cc0a613b45835307c93d8d34a3aef
http://europepmc.org/articles/PMC6770661

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Autor: Rebecca C. Wade, Jeanette Hellgren Kotaleski, Ursula Rothlisberger, Neil J. Bruce, Daniel Trpevski, Siri Camee van Keulen, Anu G. Nair, Daniele Narzi, Paolo Carloni

Publikováno v: PLoS Computational Biology
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PLoS Computational Biology, Vol 15, Iss 10, p e1007382 (2019)
PLoS Computational Biology 15(10), e1007382 (2019). doi:10.1371/journal.pcbi.1007382
PLoS Computational Biology 15(10), e1007382-(2019). doi:10.1371/journal.pcbi.1007382

Long-term potentiation and depression of synaptic activity in response to stimuli is a key factor in reinforcement learning. Strengthening of the corticostriatal synapses depends on the second messenger cAMP, whose synthesis is catalysed by the enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad54d50dd78db2cc0ed78808645fc61