Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Neil J. Ashweek"'
Autor:
Iain Coldham, Melanie C. Skilbeck, Harry Adams, Andrew T. Reeder, Thomas A. Barker, Neil J. Ashweek
Publikováno v:
Tetrahedron Letters. 51:2457-2460
Lithiation with butyllithium of 2-(benzylamino)benzamides (N-benzyl anthranilamides) occurs at the benzylic position to give an alpha-amino-organolithium that cyclizes to the 3-indolinone (indoxyl) ring (similar to a Parham cyclization). Autoxidation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba431a546cc141e111c676e862d018c2
https://doi.org/10.1016/j.tetlet.2010.02.159
https://doi.org/10.1016/j.tetlet.2010.02.159
Autor:
Deborah H. Slee, Susan K. Sullivan, Neil J. Ashweek, Marion Lanier, Yun-Fei Zhu, Jaimie K. Rueter, Miklos Feher, Colin J. Loweth, Michael S. Brown, John P. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5590-5603
The present article describes a selection of a new class of small molecule antagonists for the h-GnRH receptor, their preparation, and evaluation in vitro. Three computational methods were combined into a consensus score, to rank order virtual templa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226de7983d180f332e8e5ee93f98fa99
https://doi.org/10.1016/j.bmc.2007.05.029
https://doi.org/10.1016/j.bmc.2007.05.029
Autor:
John Saunders, Zhiqiang Guo, Xin-Jun Liu, Charles Q. Huang, Colin J. Loweth, Liren Zhao, R. Scott Struthers, Margaret J. Bradbury, Yun-Fei Zhu, James W. Behan, Stephen F. Betz, Neil J. Ashweek, Zhihong O’Brien, Marion Lanier, Jenny Wen, Mi Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3845-3850
A novel series of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives were designed and synthesized as GnRH receptor antagonists. SAR studies led to a series of highly active molecules against both the rat and human receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994be87ff74fc1edceedd710e1f1d8ed
https://doi.org/10.1016/j.bmcl.2007.05.009
https://doi.org/10.1016/j.bmcl.2007.05.009
Autor:
Gerald Pattenden, Neil J. Ashweek, Charles A. G. Baker-Glenn, Gary M. Walker, James G. K. Yee
Publikováno v:
Angewandte Chemie. 119:4437-4441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb7394844892437e5e627ff3484ad540
https://doi.org/10.1002/ange.200700459
https://doi.org/10.1002/ange.200700459
Publikováno v:
Tetrahedron. 61:3271-3280
A selection of N -substituted 2-lithiopyrrolidines were prepared and their structures were investigated by 6 Li and 13 C NMR spectroscopy. Evidence is presented for aggregation and dynamic solvation effects, depending on the nature of the N -substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d4c9b24b172b4ab751eecd366b29899
https://doi.org/10.1016/j.tet.2005.01.098
https://doi.org/10.1016/j.tet.2005.01.098
Autor:
Graciela Sanchez-Jimenez, Neil J. Ashweek, Iain Coldham, Fredrik Haeffner, Robert E. Gawley, Samuel Dufour, Rosalyn Klein, Peter Brandt
Publikováno v:
Journal of the American Chemical Society. 127:449-457
Kinetics experiments have been used to establish the free energy, enthalpy, and entropy of activation for the enantiomerization of three structural classes of 2-lithiopyrrolidines. We find that alpha-aminoorganolithiums chelated by a N-methoxyethyl o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6efb01263c5fd9d5c5b26e5e1610945
https://doi.org/10.1021/ja048090l
https://doi.org/10.1021/ja048090l
Publikováno v:
Chemistry - A European Journal. 8:195-207
Enantiomerically enriched alpha-amino-organolithium species, in which the lithium atom is attached to a stereogenic carbon centre, have been found to be chemically stable at room temperature in a solvent of very low polarity and undergo intramolecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01f2e6966310adc8ac5f39eccc6fe9bf
https://doi.org/10.1002/1521-3765(20020104)8:1<195::aid-chem195>3.0.co
https://doi.org/10.1002/1521-3765(20020104)8:1<195::aid-chem195>3.0.co
Autor:
Iain Coldham, Neil J. Ashweek, Thomas A. Barker, Harry Adams, Andrew T. Reeder, Melanie C. Skilbeck
Publikováno v:
ChemInform. 41
Regioselective lithiation of N,N-dibenzyl anthranilic amides of type (I) results in formation of the cyclization products (II) after exposure to air.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8dfb6480afc634f9613c827b5803138
https://doi.org/10.1002/chin.201034123
https://doi.org/10.1002/chin.201034123
Publikováno v:
ChemInform. 31
A new and convenient method for the formation of N-alkyl-2-tributylstannyl-pyrrolidines from N-Boc-2-tributylstannyl-pyrrolidine has been developed. The procedure uses N-Boc deprotection, followed by rapid base wash and reductive amination with an al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a72344279997b5b113e12261500424db
https://doi.org/10.1002/chin.200025115
https://doi.org/10.1002/chin.200025115
Publikováno v:
ChemInform. 33
Enantiomerically enriched alpha-amino-organolithium species, in which the lithium atom is attached to a stereogenic carbon centre, have been found to be chemically stable at room temperature in a solvent of very low polarity and undergo intramolecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0063cbaf82ea3115165ac111ed2e15c2
https://doi.org/10.1002/chin.200223130
https://doi.org/10.1002/chin.200223130