Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Neil J Gibson"'
Autor:
James R Bradford, Matthew Farren, Steve J Powell, Sarah Runswick, Susie L Weston, Helen Brown, Oona Delpuech, Mark Wappett, Neil R Smith, T Hedley Carr, Jonathan R Dry, Neil J Gibson, Simon T Barry
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66003 (2013)
Pre-clinical models of tumour biology often rely on propagating human tumour cells in a mouse. In order to gain insight into the alignment of these models to human disease segments or investigate the effects of different therapeutics, approaches such
Externí odkaz:
https://doaj.org/article/7dfb779fa8d5446c94fc9f95ab1932d3
Autor:
Neil J. Gibson, William P. Watson, William N. Hunter, Tom Brown, Katherine E. McAuley-Hecht, James B. Thomson, Gordon A. Leonard
The crystal structure of the oligonucleotide d(CGCAAATTO8GGCG), containing the chemically modified base 8-hydroxydeoxyguanine (O8G), has been determined at 2.5-A resolution and refined to a crystallographic R-factor of 16.8%. The B-type DNA helix con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b15161187ada7cea7429d6050714166
https://doi.org/10.1021/bi00200a006
https://doi.org/10.1021/bi00200a006
Publikováno v:
ChemInform. 26
Treatment of 2,3,5,5-tetramethyl-3-hydroxy-1-pyrroline 1-oxide 6, prepared from butanone in six steps, with benzoyl chloride under Schotten–Baumann conditions leads to an unprecedented dimerisation to give a spiro, tricyclic N-benzoyloxypyrrolidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::024df73816c185a8c20f415638a329e7
https://doi.org/10.1002/chin.199529136
https://doi.org/10.1002/chin.199529136
Autor:
Lucy J, Knight, Joseph, Burrage, Sarah R, Bujac, Carolyn, Haggerty, Alexander, Graham, Neil J, Gibson, Gillian, Ellison, James W, Growcott, A Nigel, Brooks, Andrew M, Hughes, George, Xinarianos, Georgios, Nikolaidis, John K, Field, Triantafillos, Liloglou
Publikováno v:
International journal of oncology. 34(2)
Endothelin-1 is overexpressed in several tumor types. Activation of the endothelin-A (ETA) receptor may promote cell growth, angiogenesis and invasion, and inhibits the apoptotic process, while activation of the endothelin-B (ETB) receptor may induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3b83677945fba27924d93847375dfe3
https://pubmed.ncbi.nlm.nih.gov/19148482
https://pubmed.ncbi.nlm.nih.gov/19148482
Adenine, thymine and cytosine PNA monomers have been prepared using 3-amino-1,2-propanediol as a starting material. The benzoyl group was used to protect the exocyclic amines of the heterocyclic bases of A and C PNA monomers and the backbone primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897ba8c22bcff3bf6ff95ac1d95100f9
https://europepmc.org/articles/PMC146105/
https://europepmc.org/articles/PMC146105/
Autor:
Tom Brown, Gordon A. Leonard, Neil J. Gibson, William P. Watson, Katherine E. McAuley-Hecht, William N. Hunter
Publikováno v:
Biochemistry. 33(16)
A single-crystal X-ray analysis of the synthetic oligomer d(CGCGAATT(epsilon dA)GCG) (epsilon dA = 1,N6-ethenoadenosine) has been carried out. The B-form duplex crystallizes in the orthorhombic space group P2(1)2(1)2(1) with unit cell dimensions a =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4642bf085ef096930860c4a6bda2d2
http://ora.ox.ac.uk/objects/uuid:a4b43c0a-adcc-4e87-bc53-3e9a837d53b0
http://ora.ox.ac.uk/objects/uuid:a4b43c0a-adcc-4e87-bc53-3e9a837d53b0
Autor:
Andrew Hughes, Sarah R. Bujac, John K. Field, Gillian Ellison, Triantafillos Liloglou, Joe Burrage, Lucy J Knight, James W Growcott, Neil J Gibson, Alexander Graham, A Nigel Brooks, Georgios Nikolaidis, Carolyn Haggerty, George Xinarianos
Publikováno v:
International Journal of Oncology.
Endothelin-1 is overexpressed in several tumor types. Activation of the endothelin-A (ETA) receptor may promote cell growth, angiogenesis and invasion, and inhibits the apoptotic process, while activation of the endothelin-B (ETB) receptor may induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be52fa7f962fee556bac5cec0f579090
https://doi.org/10.3892/ijo_00000171
https://doi.org/10.3892/ijo_00000171
Publikováno v:
J. Chem. Soc., Chem. Commun.. :2241-2242
The mutagenic lesion 3,N4-etheno-2′-deoxycytidine (IµdC) greatly destabilises DNA when paired with each of the natural bases although the solution structure of a duplex containing a IµC : A pair shows that the lesion does not greatly disrupt base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c28218bf90df26f4b5931e4bc4117f
https://doi.org/10.1039/c39940002241
https://doi.org/10.1039/c39940002241
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :507
Treatment of 2,3,5,5-tetramethyl-3-hydroxy-1-pyrroline 1-oxide 6, prepared from butanone in six steps, with benzoyl chloride under Schotten–Baumann conditions leads to an unprecedented dimerisation to give a spiro, tricyclic N-benzoyloxypyrrolidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1c51f4825d6a2541daacdf509d8c920
https://doi.org/10.1039/p19950000507
https://doi.org/10.1039/p19950000507
Autor:
Neil J. Gibson, Alexander R. Forrester
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :491
5,5-Dimethyl-1-pyrroline 1-oxide (DMPO), when treated with NaH (1 mol) followed by ethyl chloroformate, benzoyl chloride, pivaloyl chloride or 2-bromoisobutyryl bromide gave the corresponding 3-acyloxy-1-pyrrolines. With NaH (2–4 mol) followed by b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaed91f9779b3a3c56a1e7c41d5bde8f
https://doi.org/10.1039/p19950000491
https://doi.org/10.1039/p19950000491